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MCP1 - Methyl-accepting chemotaxis protein I
UniProt: P02942 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11034
Length: 551 (514)
Sequences: 4293
Seq/Len: 8.35
MCP1
Paralog alert: 0.85 [within 20: 0.27] - ratio of genomes with paralogs
Cluster includes: AER MCP1 MCP2 MCP3 MCP4
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
147_K 150_E 4.59 1.00
245_G 250_G 3.769 1.00
231_H 236_D 3.326 1.00
6_K 9_T 3.189 1.00
109_E 126_K 3.097 1.00
99_K 103_K 2.527 1.00
225_L 253_A 2.425 1.00
207_I 211_W 2.257 1.00
165_K 169_A 2.21 1.00
179_D 183_S 2.164 1.00
172_E 176_R 2.149 1.00
257_R 260_Q 2.147 1.00
103_K 107_D 2.132 1.00
26_G 200_M 2.1 1.00
120_A 124_E 2.072 1.00
410_S 414_A 2.021 1.00
92_E 96_I 1.985 1.00
176_R 180_I 1.98 1.00
194_W 198_G 1.96 1.00
405_N 408_Q 1.924 1.00
221_P 248_E 1.924 1.00
116_R 120_A 1.898 1.00
154_Q 158_G 1.872 1.00
230_R 251_Q 1.871 1.00
8_V 12_L 1.866 1.00
106_A 110_A 1.858 1.00
230_R 258_H 1.844 1.00
123_A 127_R 1.825 1.00
216_A 220_A 1.816 1.00
37_K 189_Y 1.813 1.00
138_E 141_Q 1.798 1.00
27_G 31_N 1.798 1.00
231_H 239_K 1.754 1.00
10_S 217_S 1.73 1.00
95_S 99_K 1.729 1.00
218_L 221_P 1.723 1.00
141_Q 145_A 1.718 1.00
10_S 247_N 1.701 1.00
232_I 259_M 1.695 1.00
8_V 215_K 1.684 1.00
225_L 256_L 1.684 1.00
124_E 166_Q 1.68 1.00
119_T 123_A 1.667 1.00
142_L 147_K 1.656 1.00
137_A 141_Q 1.648 1.00
128_N 166_Q 1.64 1.00
325_Q 328_H 1.635 1.00
342_K 346_N 1.634 1.00
7_I 222_M 1.63 1.00
183_S 187_A 1.629 1.00
64_R 68_N 1.629 1.00
40_F 43_L 1.614 1.00
197_V 201_I 1.597 1.00
138_E 155_P 1.589 1.00
70_A 143_L 1.585 1.00
226_I 255_S 1.579 1.00
354_I 431_G 1.577 1.00
88_A 92_E 1.573 1.00
433_T 437_S 1.564 1.00
102_E 106_A 1.562 1.00
229_I 255_S 1.539 1.00
373_F 384_V 1.529 1.00
340_G 445_I 1.526 1.00
121_A 173_Q 1.488 1.00
166_Q 169_A 1.484 1.00
46_I 49_Q 1.483 1.00
193_M 197_V 1.474 0.99
346_N 437_S 1.472 0.99
91_M 144_G 1.465 0.99
189_Y 193_M 1.457 0.99
248_E 251_Q 1.449 0.99
127_R 131_I 1.44 0.99
115_P 119_T 1.436 0.99
318_Q 321_E 1.421 0.99
107_D 110_A 1.416 0.99
506_S 510_E 1.409 0.99
24_T 28_L 1.407 0.99
168_V 172_E 1.404 0.99
14_V 18_F 1.404 0.99
353_D 427_K 1.403 0.99
360_K 363_D 1.4 0.99
203_V 206_V 1.4 0.99
41_T 45_T 1.398 0.99
49_Q 108_Y 1.393 0.99
348_V 439_G 1.391 0.99
283_E 493_E 1.391 0.99
366_S 370_G 1.385 0.99
15_L 18_F 1.382 0.99
114_D 117_Q 1.381 0.99
126_K 130_D 1.376 0.99
70_A 91_M 1.375 0.99
157_Q 161_D 1.374 0.99
138_E 142_L 1.367 0.99
22_Q 25_S 1.364 0.99
429_D 433_T 1.361 0.99
58_V 61_L 1.353 0.99
472_Q 475_L 1.352 0.99
229_I 252_L 1.347 0.99
229_I 256_L 1.346 0.99
489_A 493_E 1.343 0.99
332_S 335_E 1.341 0.99
310_E 314_A 1.337 0.99
100_Q 103_K 1.336 0.99
102_E 133_H 1.329 0.99
155_P 158_G 1.327 0.99
25_S 29_F 1.324 0.99
464_D 468_R 1.32 0.99
215_K 219_V 1.317 0.99
230_R 234_G 1.311 0.99
347_V 435_V 1.311 0.99
130_D 134_N 1.31 0.99
124_E 128_N 1.306 0.98
440_E 443_A 1.299 0.98
319_N 463_S 1.296 0.98
56_S 101_A 1.295 0.98
106_A 109_E 1.293 0.98
52_T 107_D 1.292 0.98
479_E 482_R 1.292 0.98
49_Q 174_N 1.286 0.98
125_I 163_F 1.286 0.98
440_E 444_E 1.281 0.98
351_M 354_I 1.278 0.98
92_E 95_S 1.277 0.98
96_I 99_K 1.276 0.98
96_I 100_Q 1.274 0.98
198_G 202_V 1.267 0.98
104_N 107_D 1.263 0.98
180_I 184_D 1.262 0.98
226_I 252_L 1.26 0.98
257_R 261_G 1.26 0.98
251_Q 254_E 1.257 0.98
65_N 69_R 1.257 0.98
36_D 40_F 1.254 0.98
343_V 434_L 1.254 0.98
283_E 286_T 1.252 0.98
492_E 496_A 1.251 0.98
134_N 138_E 1.251 0.98
115_P 120_A 1.249 0.98
335_E 339_R 1.246 0.98
131_I 134_N 1.242 0.98
227_D 230_R 1.239 0.98
12_L 215_K 1.237 0.98
489_A 492_E 1.236 0.98
129_Y 163_F 1.232 0.98
360_K 416_E 1.231 0.98
450_T 454_D 1.229 0.98
339_R 444_E 1.228 0.97
194_W 197_V 1.226 0.97
68_N 72_I 1.226 0.97
33_L 36_D 1.225 0.97
7_I 218_L 1.222 0.97
44_Q 48_Q 1.221 0.97
103_K 106_A 1.218 0.97
240_P 260_Q 1.216 0.97
217_S 221_P 1.215 0.97
47_R 177_L 1.214 0.97
201_I 205_A 1.209 0.97
124_E 127_R 1.208 0.97
247_N 250_G 1.203 0.97
40_F 185_N 1.202 0.97
341_G 446_V 1.202 0.97
29_F 196_L 1.202 0.97
345_D 349_Q 1.198 0.97
191_Q 195_I 1.196 0.97
451_R 454_D 1.195 0.97
225_L 252_L 1.195 0.97
337_A 446_V 1.193 0.97
311_Q 314_A 1.191 0.97
142_L 150_E 1.186 0.97
99_K 102_E 1.181 0.97
89_E 92_E 1.181 0.97
161_D 165_K 1.179 0.97
336_T 444_E 1.173 0.96
14_V 21_L 1.171 0.96
269_D 507_R 1.171 0.96
108_Y 174_N 1.17 0.96
207_I 210_V 1.169 0.96
124_E 169_A 1.167 0.96
261_G 265_R 1.163 0.96
249_M 253_A 1.162 0.96
15_L 21_L 1.16 0.96
442_M 445_I 1.158 0.96
404_R 409_R 1.154 0.96
383_A 401_G 1.15 0.96
59_A 101_A 1.149 0.96
195_I 198_G 1.148 0.96
32_A 192_A 1.148 0.96
300_A 304_E 1.146 0.96
44_Q 178_H 1.144 0.96
240_P 261_G 1.143 0.96
109_E 119_T 1.141 0.96
141_Q 144_G 1.135 0.95
265_R 269_D 1.132 0.95
351_M 431_G 1.13 0.95
98_L 137_A 1.128 0.95
383_A 404_R 1.128 0.95
90_L 93_S 1.127 0.95
428_V 431_G 1.127 0.95
436_E 440_E 1.125 0.95
223_N 248_E 1.124 0.95
409_R 416_E 1.124 0.95
229_I 259_M 1.122 0.95
221_P 250_G 1.119 0.95
317_K 471_D 1.112 0.95
324_R 464_D 1.111 0.95
259_M 263_L 1.11 0.95
28_L 32_A 1.11 0.95
222_M 252_L 1.105 0.95
339_R 437_S 1.102 0.94
471_D 474_G 1.102 0.94
238_V 517_I 1.102 0.94
338_Q 450_T 1.1 0.94
47_R 174_N 1.096 0.94
34_K 193_M 1.095 0.94
19_G 22_Q 1.095 0.94
364_I 420_L 1.095 0.94
235_G 252_L 1.094 0.94
184_D 187_A 1.093 0.94
101_A 129_Y 1.085 0.94
441_T 445_I 1.081 0.94
262_E 514_V 1.08 0.94
112_P 122_A 1.075 0.93
291_L 294_R 1.072 0.93
11_L 15_L 1.069 0.93
208_F 211_W 1.068 0.93
351_M 435_V 1.067 0.93
241_I 257_R 1.067 0.93
135_A 138_E 1.064 0.93
454_D 461_S 1.064 0.93
369_D 373_F 1.063 0.93
230_R 255_S 1.062 0.93
184_D 188_S 1.058 0.93
240_P 257_R 1.057 0.93
72_I 76_M 1.056 0.93
266_T 270_V 1.055 0.93
232_I 260_Q 1.055 0.93
108_Y 117_Q 1.054 0.93
302_L 305_T 1.05 0.92
33_L 189_Y 1.049 0.92
93_S 97_S 1.047 0.92
494_S 497_A 1.046 0.92
226_I 229_I 1.04 0.92
377_I 384_V 1.039 0.92
267_V 270_V 1.039 0.92
307_A 311_Q 1.038 0.92
158_G 162_G 1.035 0.92
198_G 205_A 1.034 0.92
328_H 331_L 1.032 0.92
500_A 503_E 1.031 0.91
466_Q 469_G 1.031 0.91
244_D 250_G 1.03 0.91
162_G 166_Q 1.028 0.91
287_G 490_L 1.027 0.91
31_N 35_N 1.024 0.91
338_Q 342_K 1.024 0.91
227_D 231_H 1.023 0.91
425_V 428_V 1.022 0.91
304_E 472_Q 1.02 0.91
221_P 252_L 1.02 0.91
116_R 173_Q 1.017 0.91
86_T 89_E 1.016 0.91
29_F 43_L 1.015 0.91
109_E 122_A 1.014 0.91
489_A 496_A 1.012 0.90
93_S 96_I 1.011 0.90
337_A 445_I 1.009 0.90
472_Q 476_A 1.007 0.90
186_N 190_S 1.004 0.90
352_R 436_E 1.003 0.90
185_N 189_Y 1.003 0.90
253_A 257_R 1.002 0.90
6_K 251_Q 1.002 0.90
272_N 275_N 1.002 0.90
278_Y 282_S 1.001 0.90
127_R 130_D 1.001 0.90
42_V 46_I 1 0.90
337_A 439_G 1 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zx6A20.61161000.388Contact Map0.586
1qu7A20.4121000.561Contact Map0.509
2ch7A10.48461000.612Contact Map0.343
3g67A20.38661000.663Contact Map0.677
4i3mA10.30851000.775Contact Map0.488
4gn0A40.188799.40.88Contact Map0.724
2d4uA20.306799.30.887Contact Map0.606
2ligA20.292299.20.89Contact Map0.622
2f95B10.292299.20.891Contact Map0.454
3zccA20.1978990.899Contact Map0.638
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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