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MCP3 - Methyl-accepting chemotaxis protein III
UniProt: P05704 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11018
Length: 546 (516)
Sequences: 3154
Seq/Len: 6.11
MCP3
Paralog alert: 0.86 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: AER MCP1 MCP2 MCP3 MCP4
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
152_M 155_A 4.827 1.00
253_G 258_G 3.642 1.00
239_K 244_D 3.407 1.00
233_A 261_S 2.32 1.00
413_T 416_S 2.285 1.00
229_P 256_E 2.285 1.00
265_Q 268_Q 2.25 1.00
173_D 177_K 2.165 1.00
162_E 166_P 2.113 1.00
238_E 259_R 2.106 1.00
187_N 191_E 2.069 1.00
101_S 105_Q 2.027 1.00
125_A 129_E 2.014 1.00
418_S 422_A 2.012 1.00
238_E 266_Q 1.987 1.00
180_K 184_T 1.957 1.00
362_I 439_G 1.945 1.00
128_T 132_Q 1.911 1.00
143_P 147_Y 1.894 1.00
348_G 453_I 1.88 1.00
122_A 125_A 1.875 1.00
239_K 247_M 1.859 1.00
355_V 443_V 1.849 1.00
184_T 188_Q 1.846 1.00
104_K 108_Q 1.824 1.00
201_G 205_I 1.767 1.00
202_M 206_G 1.752 1.00
226_V 229_P 1.75 1.00
224_R 228_R 1.748 1.00
108_Q 112_A 1.743 1.00
205_I 209_V 1.74 1.00
147_Y 152_M 1.688 1.00
350_Q 354_G 1.677 1.00
176_N 180_K 1.648 1.00
110_Y 113_Y 1.648 1.00
356_V 447_G 1.64 1.00
256_E 259_R 1.626 1.00
108_Q 111_R 1.621 1.00
16_R 19_P 1.62 1.00
197_T 201_G 1.609 1.00
124_E 128_T 1.605 0.99
437_D 441_D 1.594 0.99
233_A 264_L 1.594 0.99
121_P 124_E 1.581 0.99
237_I 263_H 1.58 0.99
381_F 392_V 1.576 0.99
97_A 101_S 1.57 0.99
318_E 322_A 1.57 0.99
229_P 260_L 1.563 0.99
349_G 454_V 1.563 0.99
327_N 471_S 1.561 0.99
374_A 378_S 1.556 0.99
487_E 490_K 1.554 0.99
497_S 500_E 1.551 0.99
500_E 504_A 1.549 0.99
191_E 195_Q 1.544 0.99
158_N 162_E 1.542 0.99
291_E 501_E 1.539 0.99
133_R 174_I 1.531 0.99
231_Q 256_E 1.514 0.99
441_D 445_T 1.504 0.99
147_Y 155_A 1.488 0.99
223_R 227_I 1.483 0.99
234_A 263_H 1.459 0.99
209_V 213_V 1.452 0.99
354_G 445_T 1.442 0.99
85_R 88_E 1.437 0.99
105_Q 109_G 1.436 0.99
259_R 262_R 1.434 0.99
316_S 480_Q 1.423 0.99
347_D 452_T 1.423 0.99
267_M 271_L 1.422 0.99
345_A 454_V 1.418 0.98
333_H 336_K 1.414 0.98
240_I 267_M 1.413 0.98
248_N 272_G 1.402 0.98
100_E 142_Q 1.378 0.98
46_A 50_Q 1.369 0.98
274_T 278_V 1.367 0.98
264_L 268_Q 1.365 0.98
206_G 210_L 1.361 0.98
76_N 79_Q 1.357 0.98
135_Q 139_T 1.352 0.98
458_A 462_H 1.351 0.98
459_S 462_H 1.343 0.98
261_S 267_M 1.336 0.98
43_L 46_A 1.335 0.97
305_E 308_A 1.335 0.97
233_A 260_L 1.332 0.97
71_R 76_N 1.326 0.97
514_A 518_E 1.326 0.97
132_Q 136_A 1.321 0.97
351_T 442_E 1.316 0.97
134_F 171_Y 1.311 0.97
237_I 264_L 1.305 0.97
361_A 435_L 1.3 0.97
142_Q 146_K 1.299 0.97
215_T 219_F 1.29 0.97
111_R 131_N 1.286 0.97
140_G 143_P 1.285 0.97
462_H 469_A 1.283 0.97
412_R 417_R 1.28 0.97
109_G 112_A 1.272 0.96
74_R 79_Q 1.272 0.96
479_T 482_S 1.271 0.96
20_L 23_C 1.27 0.96
50_Q 53_V 1.266 0.96
368_K 371_E 1.263 0.96
448_K 452_T 1.261 0.96
352_V 446_A 1.256 0.96
131_N 135_Q 1.251 0.96
143_P 146_K 1.251 0.96
237_I 260_L 1.249 0.96
129_E 177_K 1.249 0.96
277_T 515_R 1.24 0.96
229_P 258_G 1.237 0.96
361_A 364_T 1.237 0.96
120_T 123_D 1.235 0.96
497_S 504_A 1.232 0.95
368_K 424_E 1.231 0.95
248_N 269_H 1.23 0.95
255_N 258_G 1.229 0.95
313_T 484_A 1.228 0.95
480_Q 484_A 1.227 0.95
497_S 501_E 1.224 0.95
344_K 452_T 1.224 0.95
359_M 362_I 1.222 0.95
90_E 94_R 1.22 0.95
326_Q 329_D 1.22 0.95
240_I 268_Q 1.214 0.95
360_G 444_A 1.21 0.95
248_N 268_Q 1.21 0.95
229_P 257_I 1.21 0.95
480_Q 483_Q 1.209 0.95
391_A 409_S 1.209 0.95
234_A 260_L 1.208 0.95
377_N 381_F 1.205 0.95
265_Q 269_H 1.203 0.95
391_A 412_R 1.201 0.95
448_K 451_S 1.2 0.95
143_P 163_Q 1.198 0.94
174_I 177_K 1.196 0.94
436_I 439_G 1.195 0.94
129_E 174_I 1.194 0.94
123_D 182_R 1.193 0.94
20_L 24_I 1.19 0.94
343_I 347_D 1.19 0.94
372_I 428_L 1.189 0.94
319_Q 322_A 1.188 0.94
25_L 28_I 1.187 0.94
515_R 518_E 1.187 0.94
165_R 169_N 1.187 0.94
331_A 471_S 1.182 0.94
71_R 75_I 1.179 0.94
329_D 332_H 1.178 0.94
24_I 28_I 1.177 0.94
416_S 420_Q 1.176 0.94
322_A 326_Q 1.171 0.94
94_R 98_Q 1.169 0.93
257_I 261_S 1.168 0.93
146_K 150_N 1.158 0.93
110_Y 127_D 1.155 0.93
346_S 350_Q 1.151 0.93
385_I 392_V 1.149 0.93
273_M 277_T 1.146 0.93
73_A 76_N 1.146 0.93
307_A 493_Q 1.145 0.93
470_A 474_Q 1.142 0.92
93_K 149_K 1.14 0.92
487_E 491_V 1.139 0.92
381_F 422_A 1.135 0.92
129_E 133_R 1.134 0.92
225_I 229_P 1.133 0.92
203_F 206_G 1.13 0.92
472_D 476_R 1.13 0.92
163_Q 166_P 1.128 0.92
100_E 104_K 1.128 0.92
315_A 319_Q 1.126 0.92
111_R 115_N 1.123 0.92
248_N 265_Q 1.12 0.91
147_Y 159_H 1.119 0.91
144_M 156_I 1.115 0.91
137_Y 141_M 1.11 0.91
71_R 78_I 1.109 0.91
392_V 489_D 1.109 0.91
237_I 267_M 1.106 0.91
229_P 234_A 1.105 0.91
129_E 132_Q 1.104 0.91
155_A 158_N 1.101 0.90
346_S 458_A 1.099 0.90
381_F 385_I 1.099 0.90
301_S 305_E 1.098 0.90
107_Q 111_R 1.097 0.90
321_T 478_I 1.092 0.90
202_M 205_I 1.091 0.90
269_H 273_M 1.091 0.90
243_G 260_L 1.088 0.90
306_Q 491_V 1.087 0.90
302_R 491_V 1.086 0.90
126_L 181_I 1.086 0.90
188_Q 192_L 1.085 0.90
352_V 447_G 1.085 0.90
216_L 220_M 1.081 0.89
332_H 472_D 1.08 0.89
110_Y 182_R 1.08 0.89
246_T 525_L 1.079 0.89
244_D 247_M 1.078 0.89
219_F 223_R 1.078 0.89
85_R 89_M 1.078 0.89
88_E 91_A 1.077 0.89
375_V 419_A 1.077 0.89
249_D 265_Q 1.076 0.89
344_K 449_T 1.076 0.89
44_W 48_R 1.072 0.89
231_Q 259_R 1.071 0.89
18_V 22_A 1.069 0.89
256_E 262_R 1.068 0.89
178_A 182_R 1.066 0.89
104_K 107_Q 1.065 0.88
91_A 94_R 1.065 0.88
378_S 413_T 1.064 0.88
461_T 464_M 1.064 0.88
355_V 446_A 1.06 0.88
336_K 340_E 1.057 0.88
450_M 453_I 1.056 0.88
356_V 443_V 1.054 0.88
234_A 259_R 1.054 0.88
477_G 480_Q 1.053 0.88
156_I 159_H 1.05 0.88
236_R 261_S 1.047 0.87
310_I 313_T 1.046 0.87
308_A 315_A 1.045 0.87
20_L 25_L 1.045 0.87
314_A 318_E 1.043 0.87
79_Q 82_A 1.042 0.87
444_A 448_K 1.041 0.87
32_F 35_S 1.038 0.87
238_E 263_H 1.037 0.87
502_A 505_A 1.036 0.87
123_D 178_A 1.035 0.86
170_A 174_I 1.034 0.86
159_H 163_Q 1.032 0.86
234_A 256_E 1.031 0.86
377_N 419_A 1.031 0.86
57_I 60_R 1.029 0.86
321_T 482_S 1.029 0.86
340_E 343_I 1.028 0.86
182_R 185_R 1.028 0.86
139_T 143_P 1.025 0.86
385_I 413_T 1.022 0.86
312_Q 480_Q 1.021 0.85
77_M 80_A 1.019 0.85
255_N 259_R 1.017 0.85
291_E 294_A 1.016 0.85
260_L 267_M 1.016 0.85
40_G 44_W 1.015 0.85
154_E 158_N 1.014 0.85
92_M 95_N 1.011 0.85
342_S 457_V 1.01 0.85
325_K 479_T 1.01 0.85
330_N 470_A 1.01 0.85
198_R 201_G 1.009 0.85
359_M 439_G 1.009 0.85
357_K 361_A 1.007 0.84
23_C 27_G 1.005 0.84
252_A 258_G 1.004 0.84
501_E 504_A 1.003 0.84
56_E 60_R 1.002 0.84
101_S 104_K 1 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zx6A20.58791000.42Contact Map0.55
1qu7A20.41581000.54Contact Map0.53
2ch7A10.4891000.593Contact Map0.33
3g67A20.39011000.646Contact Map0.582
4i3mA10.30951000.761Contact Map0.38
4gn0A40.190599.40.871Contact Map0.632
2f95B10.296799.30.882Contact Map0.345
3zccA20.199699.10.891Contact Map0.565
4gycB10.2473990.894Contact Map0.408
2aswA20.100798.70.906Contact Map0.576
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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