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OPENSEQ.org

FRE - PYRD
UniProt: P0AEN1 - P0A7E1
Length: 569
Sequences: 565
Seq/Len: 1.18
I_Prob: 0.00

FRE - NAD(P)H-flavin reductase
Paralog alert: 0.73 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: FENR FRE
PYRD - Dihydroorotate dehydrogenase (quinone)
Paralog alert: 0.39 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: PYRD
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
1ep3A:B:AContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
21_V 274_K 1.25 0.00
87_I 271_L 1.17 0.00
147_Y 214_I 1.09 0.00
121_I 197_I 1.07 0.00
207_A 76_A 1.07 0.00
199_Y 81_S 1.07 0.00
47_R 99_R 1.06 0.00
85_H 317_I 1.05 0.00
196_H 137_G 1.04 0.00
90_D 73_A 0.99 0.00
39_V 334_T 0.98 0.00
113_T 116_N 0.98 0.00
47_R 139_N 0.98 0.00
75_K 317_I 0.97 0.00
33_A 137_G 0.96 0.00
87_I 307_K 0.93 0.00
118_A 185_Q 0.92 0.00
23_I 49_C 0.91 0.00
47_R 177_N 0.91 0.00
45_D 99_R 0.91 0.00
17_T 254_V 0.88 0.00
7_K 153_D 0.87 0.00
90_D 70_C 0.87 0.00
95_E 317_I 0.87 0.00
38_M 87_V 0.87 0.00
111_G 115_F 0.86 0.00
46_K 88_T 0.86 0.00
118_A 219_A 0.86 0.00
178_R 154_D 0.86 0.00
39_V 120_V 0.85 0.00
165_V 195_T 0.85 0.00
156_S 98_P 0.84 0.00
184_T 162_I 0.84 0.00
63_L 251_R 0.83 0.00
11_V 182_R 0.83 0.00
118_A 146_T 0.82 0.00
72_L 299_D 0.82 0.00
162_L 153_D 0.82 0.00
207_A 135_V 0.81 0.00
21_V 58_L 0.81 0.00
49_F 88_T 0.80 0.00
82_L 58_L 0.80 0.00
122_L 71_I 0.80 0.00
120_S 215_A 0.79 0.00
57_E 334_T 0.79 0.00
118_A 316_Q 0.79 0.00
8_V 219_A 0.78 0.00
91_I 81_S 0.78 0.00
37_L 222_L 0.78 0.00
8_V 158_C 0.78 0.00
93_H 184_L 0.78 0.00
28_A 298_I 0.78 0.00
199_Y 77_M 0.78 0.00
51_M 166_A 0.78 0.00
8_V 335_H 0.77 0.00
135_T 254_V 0.77 0.00
205_E 278_I 0.77 0.00
52_A 116_N 0.76 0.00
45_D 177_N 0.76 0.00
179_T 198_K 0.76 0.00
139_G 142_K 0.76 0.00
116_S 116_N 0.75 0.00
19_Y 196_A 0.75 0.00
18_V 241_G 0.75 0.00
89_V 309_A 0.75 0.00
39_V 133_D 0.74 0.00
103_E 331_E 0.74 0.00
50_S 56_N 0.74 0.00
109_I 58_L 0.74 0.00
21_V 323_F 0.73 0.00
82_L 137_G 0.73 0.00
45_D 95_N 0.73 0.00
92_P 319_S 0.73 0.00
170_Q 219_A 0.73 0.00
33_A 197_I 0.73 0.00
13_A 91_P 0.73 0.00
43_E 53_T 0.72 0.00
143_E 293_I 0.72 0.00
103_E 274_K 0.72 0.00
66_G 216_V 0.72 0.00
175_W 222_L 0.72 0.00
87_I 272_Q 0.72 0.00
116_S 130_A 0.72 0.00
139_G 115_F 0.72 0.00
207_A 97_K 0.72 0.00
59_G 317_I 0.72 0.00
170_Q 58_L 0.71 0.00
47_R 95_N 0.71 0.00
61_I 120_V 0.71 0.00
201_A 220_P 0.71 0.00
200_I 292_I 0.71 0.00
93_H 218_I 0.71 0.00
105_P 276_T 0.71 0.00
11_V 75_G 0.70 0.00
73_Y 102_R 0.70 0.00
32_R 70_C 0.70 0.00
74_A 123_L 0.70 0.00
118_A 52_L 0.70 0.00
108_L 73_A 0.70 0.00
213_L 223_S 0.70 0.00
86_Q 211_Y 0.70 0.00
126_L 133_D 0.70 0.00
137_Y 301_V 0.69 0.00
63_L 169_I 0.69 0.00
62_E 227_L 0.69 0.00
16_D 183_T 0.69 0.00
107_I 249_L 0.69 0.00
100_D 146_T 0.69 0.00
23_I 266_L 0.69 0.00
109_I 210_K 0.69 0.00
33_A 152_K 0.68 0.00
199_Y 75_G 0.68 0.00
120_S 243_I 0.68 0.00
42_D 242_V 0.68 0.00
115_F 133_D 0.68 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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