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OPENSEQ.org
PYRD - Dihydroorotate dehydrogenase (quinone)
UniProt: P0A7E1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10807
Length: 336 (335)
Sequences: 2442
Seq/Len: 7.29
PYRD
Paralog alert: 0.39 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
301_V 335_H 3.999 1.00
121_D 161_K 3.767 1.00
48_N 53_T 3.698 1.00
191_D 236_R 2.876 1.00
50_M 215_A 2.801 1.00
46_P 53_T 2.796 1.00
160_E 200_K 2.782 1.00
324_K 331_E 2.67 1.00
198_K 240_D 2.665 1.00
283_S 313_S 2.624 1.00
54_F 314_L 2.611 1.00
276_T 307_K 2.489 1.00
191_D 237_H 2.44 1.00
228_I 285_E 2.439 1.00
244_A 282_L 2.394 1.00
275_S 307_K 2.387 1.00
198_K 214_I 2.383 1.00
87_V 123_L 2.366 1.00
190_L 234_L 2.307 1.00
215_A 241_G 2.265 1.00
299_D 303_A 2.174 1.00
272_Q 306_E 2.098 1.00
279_I 292_I 2.097 1.00
300_S 303_A 2.056 1.00
52_L 168_Y 1.99 1.00
272_Q 307_K 1.975 1.00
298_I 315_V 1.902 1.00
304_A 332_I 1.893 1.00
243_I 295_V 1.861 1.00
272_Q 303_A 1.845 1.00
59_G 83_E 1.831 1.00
235_V 290_L 1.799 1.00
283_S 288_G 1.771 1.00
156_L 200_K 1.766 1.00
56_N 80_G 1.738 1.00
159_M 169_I 1.737 1.00
59_G 81_S 1.718 1.00
150_Q 153_D 1.71 1.00
107_E 269_R 1.701 1.00
173_I 190_L 1.7 1.00
58_L 298_I 1.683 1.00
242_V 286_L 1.679 1.00
90_R 145_D 1.665 1.00
191_D 195_T 1.635 1.00
302_I 306_E 1.627 1.00
7_R 11_F 1.582 1.00
317_I 332_I 1.561 1.00
159_M 197_I 1.552 1.00
304_A 315_V 1.541 1.00
88_T 141_G 1.534 1.00
304_A 336_I 1.512 0.99
140_I 159_M 1.502 0.99
163_Y 211_Y 1.486 0.99
305_R 309_A 1.486 0.99
88_T 92_Q 1.483 0.99
58_L 332_I 1.479 0.99
283_S 287_N 1.473 0.99
140_I 158_C 1.463 0.99
248_T 274_K 1.458 0.99
56_N 333_V 1.452 0.99
138_I 166_A 1.447 0.99
223_S 226_E 1.441 0.99
55_K 133_D 1.439 0.99
331_E 335_H 1.438 0.99
232_D 236_R 1.42 0.99
137_G 168_Y 1.408 0.99
320_G 328_L 1.402 0.99
89_P 143_N 1.4 0.99
118_L 122_N 1.395 0.99
84_I 138_I 1.382 0.99
157_I 160_E 1.381 0.99
197_I 214_I 1.376 0.99
83_E 316_Q 1.374 0.99
86_T 139_N 1.362 0.99
49_C 314_L 1.348 0.98
300_S 328_L 1.345 0.98
279_I 294_G 1.343 0.98
283_S 292_I 1.339 0.98
86_T 141_G 1.337 0.98
301_V 305_R 1.327 0.98
248_T 271_L 1.325 0.98
298_I 307_K 1.325 0.98
120_V 162_I 1.322 0.98
106_A 257_M 1.318 0.98
245_T 248_T 1.318 0.98
89_P 158_C 1.316 0.98
152_K 156_L 1.312 0.98
122_N 126_N 1.301 0.98
231_A 282_L 1.295 0.98
295_V 316_Q 1.289 0.98
84_I 123_L 1.288 0.98
175_S 178_T 1.279 0.98
291_P 313_S 1.274 0.98
143_N 146_T 1.271 0.97
233_S 237_H 1.264 0.97
304_A 335_H 1.26 0.97
120_V 161_K 1.259 0.97
301_V 332_I 1.253 0.97
45_K 333_V 1.249 0.97
325_G 331_E 1.232 0.97
235_V 287_N 1.225 0.97
187_G 229_Q 1.22 0.97
228_I 281_R 1.218 0.96
305_R 336_I 1.21 0.96
194_L 216_V 1.21 0.96
330_K 334_T 1.205 0.96
163_Y 210_K 1.196 0.96
231_A 286_L 1.188 0.96
224_E 281_R 1.185 0.96
67_D 118_L 1.177 0.95
58_L 333_V 1.171 0.95
10_L 22_T 1.165 0.95
215_A 293_I 1.163 0.95
59_G 316_Q 1.162 0.95
103_L 106_A 1.153 0.95
115_F 141_G 1.143 0.94
95_N 99_R 1.136 0.94
272_Q 276_T 1.132 0.94
198_K 201_Q 1.132 0.94
45_K 57_P 1.128 0.94
181_L 184_L 1.127 0.94
216_V 239_I 1.113 0.93
147_P 150_Q 1.109 0.93
244_A 278_I 1.107 0.93
152_K 196_A 1.103 0.93
222_L 230_V 1.102 0.93
157_I 161_K 1.1 0.93
302_I 335_H 1.1 0.93
152_K 192_D 1.099 0.93
269_R 299_D 1.098 0.93
294_G 307_K 1.091 0.92
23_F 70_C 1.091 0.92
92_Q 141_G 1.081 0.92
308_I 336_I 1.08 0.92
113_M 117_N 1.078 0.92
276_T 310_A 1.076 0.92
144_K 179_P 1.073 0.92
52_L 135_V 1.071 0.92
146_T 154_D 1.07 0.92
120_V 158_C 1.07 0.92
156_L 196_A 1.065 0.91
125_E 128_K 1.064 0.91
100_L 113_M 1.053 0.91
162_I 169_I 1.052 0.91
120_V 124_V 1.051 0.91
235_V 289_R 1.05 0.90
54_F 168_Y 1.046 0.90
169_I 212_V 1.045 0.90
78_G 334_T 1.044 0.90
250_D 274_K 1.044 0.90
224_E 228_I 1.04 0.90
83_E 243_I 1.033 0.90
176_P 265_G 1.03 0.89
277_E 280_R 1.03 0.89
59_G 314_L 1.026 0.89
279_I 307_K 1.025 0.89
78_G 330_K 1.018 0.89
317_I 328_L 1.016 0.88
92_Q 143_N 1.012 0.88
153_D 157_I 1.01 0.88
94_G 119_G 1.001 0.87
68_G 123_L 1.001 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3i65A10.97921000.289Contact Map0.819
1tv5A10.97921000.314Contact Map0.801
3zwtA10.97921000.337Contact Map0.766
1f76A411000.351Contact Map0.843
4ighA10.97921000.359Contact Map0.755
1ep3A10.81851000.507Contact Map0.771
4ef8A20.90181000.514Contact Map0.79
1gteA40.94641000.525Contact Map0.76
3oixA40.89291000.525Contact Map0.697
1jubA20.81851000.53Contact Map0.757
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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