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SAPA - Peptide transport periplasmic protein SapA
UniProt: Q47622 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG20254
Length: 547 (501)
Sequences: 9253
Seq/Len: 18.47
SAPA
Paralog alert: 0.87 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: DDPA DPPA GSIB MPPA NIKA OPPA SAPA SGRR YBAE YEJA YGIS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
108_K 116_R 4.509 1.00
221_S 232_Q 4.472 1.00
313_A 370_S 4.07 1.00
164_D 167_T 3.925 1.00
325_Q 329_Q 3.869 1.00
163_L 169_E 3.787 1.00
363_K 366_E 3.731 1.00
161_R 169_E 3.687 1.00
102_R 166_H 3.449 1.00
219_Q 232_Q 3.32 1.00
481_S 486_A 3.311 1.00
473_S 477_K 3.275 1.00
124_V 128_Q 3.139 1.00
466_W 501_E 3.097 1.00
124_V 162_K 3.025 1.00
86_S 99_H 2.972 1.00
454_C 467_C 2.926 1.00
377_T 410_K 2.893 1.00
318_L 404_M 2.882 1.00
470_K 473_S 2.871 1.00
366_E 370_S 2.787 1.00
88_E 99_H 2.763 1.00
121_D 162_K 2.756 1.00
320_L 363_K 2.752 1.00
323_N 326_R 2.743 1.00
307_P 310_N 2.741 1.00
73_D 78_R 2.689 1.00
454_C 472_D 2.593 1.00
312_P 316_H 2.566 1.00
313_A 367_Q 2.547 1.00
193_A 197_R 2.542 1.00
70_L 87_W 2.531 1.00
486_A 489_E 2.52 1.00
468_D 501_E 2.513 1.00
118_M 215_T 2.48 1.00
313_A 316_H 2.462 1.00
468_D 497_I 2.45 1.00
405_A 410_K 2.412 1.00
90_L 94_A 2.379 1.00
161_R 171_R 2.336 1.00
95_T 169_E 2.334 1.00
470_K 493_E 2.325 1.00
219_Q 235_D 2.295 1.00
95_T 171_R 2.256 1.00
85_E 102_R 2.253 1.00
483_Q 486_A 2.245 1.00
107_Q 234_H 2.228 1.00
97_R 169_E 2.226 1.00
104_V 118_M 2.224 1.00
127_F 170_F 2.223 1.00
73_D 80_M 2.219 1.00
105_P 117_K 2.219 1.00
99_H 167_T 2.205 1.00
89_V 96_Y 2.164 1.00
377_T 412_V 2.15 1.00
477_K 490_A 2.148 1.00
379_K 412_V 2.132 1.00
105_P 236_D 2.126 1.00
123_V 168_V 2.125 1.00
230_R 246_Q 2.116 1.00
218_Y 244_M 2.072 1.00
302_F 505_L 2.06 1.00
489_E 493_E 2.048 1.00
116_R 194_E 2.047 1.00
35_G 246_Q 2.043 1.00
158_K 173_A 2.028 1.00
119_N 122_D 2.006 1.00
306_K 431_D 1.991 1.00
48_N 129_R 1.979 1.00
316_H 363_K 1.972 1.00
302_F 432_L 1.969 1.00
121_D 193_A 1.94 1.00
471_F 494_A 1.908 1.00
67_D 82_E 1.89 1.00
521_K 537_Y 1.882 1.00
35_G 248_V 1.877 1.00
496_S 500_Q 1.877 1.00
103_D 117_K 1.872 1.00
122_D 193_A 1.865 1.00
521_K 539_E 1.853 1.00
474_V 493_E 1.837 1.00
121_D 165_N 1.821 1.00
478_A 491_Y 1.819 1.00
75_Y 78_R 1.819 1.00
261_K 266_E 1.809 1.00
318_L 409_V 1.807 1.00
121_D 124_V 1.793 1.00
224_R 227_Q 1.783 1.00
401_Q 405_A 1.777 1.00
339_A 509_S 1.775 1.00
490_A 493_E 1.749 1.00
360_N 363_K 1.748 1.00
379_K 414_V 1.745 1.00
222_E 230_R 1.738 1.00
365_R 369_K 1.726 1.00
85_E 99_H 1.718 1.00
286_R 518_Y 1.716 1.00
322_I 400_I 1.711 1.00
493_E 496_S 1.708 1.00
232_Q 246_Q 1.696 1.00
108_K 192_S 1.692 1.00
39_C 267_C 1.682 1.00
221_S 246_Q 1.675 1.00
319_A 502_L 1.674 1.00
159_S 171_R 1.664 1.00
87_W 98_F 1.663 1.00
70_L 98_F 1.656 1.00
312_P 501_E 1.65 1.00
478_A 490_A 1.649 1.00
309_L 318_L 1.639 1.00
309_L 378_L 1.638 1.00
233_R 245_P 1.636 1.00
222_E 228_F 1.63 1.00
90_L 97_R 1.623 1.00
469_P 473_S 1.609 1.00
477_K 486_A 1.593 1.00
37_V 248_V 1.59 1.00
120_A 162_K 1.582 1.00
243_L 537_Y 1.58 1.00
474_V 490_A 1.568 1.00
116_R 192_S 1.567 1.00
263_L 280_I 1.56 1.00
119_N 165_N 1.556 1.00
443_D 487_R 1.553 1.00
224_R 228_F 1.553 1.00
104_V 215_T 1.548 1.00
470_K 497_I 1.544 1.00
314_V 371_L 1.538 1.00
314_V 368_L 1.535 1.00
252_G 261_K 1.526 1.00
489_E 492_D 1.507 1.00
85_E 101_R 1.505 1.00
90_L 95_T 1.502 1.00
321_A 407_V 1.499 1.00
362_A 365_R 1.498 1.00
367_Q 370_S 1.492 1.00
107_Q 219_Q 1.482 1.00
486_A 490_A 1.478 1.00
97_R 167_T 1.451 1.00
228_F 248_V 1.439 1.00
467_C 472_D 1.436 1.00
422_E 427_D 1.436 1.00
34_S 245_P 1.434 1.00
54_S 57_I 1.432 1.00
288_R 518_Y 1.426 1.00
328_M 338_T 1.426 1.00
424_R 429_S 1.42 1.00
67_D 215_T 1.409 1.00
163_L 167_T 1.408 1.00
170_F 179_F 1.405 0.99
117_K 166_H 1.399 0.99
305_A 465_H 1.391 0.99
488_I 492_D 1.384 0.99
67_D 238_W 1.383 0.99
325_Q 338_T 1.383 0.99
99_H 166_H 1.381 0.99
101_R 104_V 1.376 0.99
162_K 165_N 1.372 0.99
233_R 242_P 1.37 0.99
316_H 502_L 1.364 0.99
312_P 500_Q 1.355 0.99
120_A 163_L 1.348 0.99
230_R 248_V 1.338 0.99
497_I 501_E 1.334 0.99
481_S 490_A 1.331 0.99
192_S 195_Y 1.325 0.99
279_S 282_R 1.324 0.99
261_K 267_C 1.324 0.99
366_E 369_K 1.311 0.99
474_V 497_I 1.303 0.99
394_L 398_E 1.298 0.99
231_L 249_V 1.286 0.99
466_W 471_F 1.28 0.99
105_P 234_H 1.276 0.99
361_P 407_V 1.275 0.99
96_Y 179_F 1.275 0.99
268_D 517_R 1.275 0.99
453_S 476_R 1.267 0.99
403_D 406_Q 1.248 0.99
33_D 245_P 1.245 0.98
123_V 190_V 1.243 0.98
268_D 519_D 1.243 0.98
99_H 102_R 1.242 0.98
257_G 261_K 1.239 0.98
316_H 367_Q 1.231 0.98
81_P 87_W 1.227 0.98
107_Q 220_L 1.218 0.98
232_Q 235_D 1.218 0.98
288_R 516_Y 1.21 0.98
124_V 160_V 1.201 0.98
107_Q 236_D 1.201 0.98
414_V 424_R 1.197 0.98
399_L 403_D 1.185 0.98
473_S 476_R 1.185 0.98
158_K 171_R 1.184 0.98
332_Y 336_A 1.174 0.98
306_K 310_N 1.17 0.97
221_S 230_R 1.17 0.97
362_A 366_E 1.165 0.97
474_V 477_K 1.163 0.97
108_K 194_E 1.158 0.97
345_R 509_S 1.155 0.97
470_K 474_V 1.155 0.97
99_H 164_D 1.146 0.97
477_K 481_S 1.145 0.97
90_L 93_G 1.142 0.97
361_P 365_R 1.14 0.97
85_E 166_H 1.136 0.97
428_M 465_H 1.132 0.97
83_L 215_T 1.13 0.97
262_L 515_A 1.121 0.97
301_A 433_T 1.118 0.96
328_M 336_A 1.11 0.96
39_C 258_R 1.107 0.96
321_A 404_M 1.105 0.96
174_Q 480_S 1.103 0.96
98_F 170_F 1.102 0.96
320_L 357_T 1.1 0.96
160_V 168_V 1.097 0.96
233_R 241_K 1.097 0.96
37_V 250_D 1.092 0.96
302_F 318_L 1.087 0.96
36_F 520_I 1.083 0.96
97_R 163_L 1.081 0.95
404_M 411_V 1.081 0.95
378_L 432_L 1.077 0.95
327_L 396_T 1.077 0.95
101_R 238_W 1.072 0.95
477_K 493_E 1.072 0.95
401_Q 413_I 1.066 0.95
291_L 511_L 1.064 0.95
43_Q 223_Y 1.064 0.95
96_Y 180_L 1.06 0.95
128_Q 162_K 1.049 0.94
312_P 502_L 1.042 0.94
326_R 403_D 1.04 0.94
124_V 168_V 1.031 0.94
68_R 82_E 1.031 0.94
287_L 515_A 1.023 0.93
117_K 165_N 1.022 0.93
71_D 80_M 1.021 0.93
88_E 97_R 1.02 0.93
400_I 404_M 1.01 0.93
313_A 371_L 1.006 0.93
98_F 180_L 1.004 0.93
319_A 324_N 1.003 0.93
36_F 269_V 1.002 0.92
71_D 82_E 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1dpeA10.91041000.151Contact Map0.797
3m8uA10.92691000.153Contact Map0.788
3tpaA10.93241000.159Contact Map0.755
1uqwA20.90311000.175Contact Map0.786
1xocA10.91221000.178Contact Map0.761
4fajA10.92871000.18Contact Map0.727
3o9pA10.90681000.18Contact Map0.737
3zs6A10.88481000.184Contact Map0.749
4gl8A20.9251000.192Contact Map0.794
1jetA10.90491000.195Contact Map0.794
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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