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OPENSEQ.org
OPPA - Periplasmic oligopeptide-binding protein
UniProt: P23843 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10674
Length: 543 (505)
Sequences: 9300
Seq/Len: 18.42
OPPA
Paralog alert: 0.87 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: DDPA DPPA GSIB MPPA NIKA OPPA SAPA SGRR YBAE YEJA YGIS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
220_K 231_E 4.711 1.00
314_R 376_E 4.017 1.00
326_D 330_N 4.01 1.00
166_D 169_T 3.952 1.00
165_I 171_E 3.885 1.00
369_E 372_K 3.829 1.00
163_K 171_E 3.786 1.00
104_K 168_H 3.565 1.00
218_T 231_E 3.404 1.00
482_V 487_Q 3.393 1.00
474_S 478_E 3.359 1.00
120_V 124_Q 3.219 1.00
467_Y 502_D 3.177 1.00
120_V 164_A 3.127 1.00
89_S 101_H 3.079 1.00
372_K 376_E 2.964 1.00
386_T 415_N 2.902 1.00
117_Q 164_A 2.896 1.00
471_A 474_S 2.888 1.00
319_L 408_W 2.886 1.00
324_D 327_I 2.883 1.00
91_D 101_H 2.824 1.00
321_L 369_E 2.824 1.00
308_P 311_N 2.794 1.00
77_D 81_H 2.666 1.00
313_V 317_T 2.638 1.00
487_Q 490_A 2.592 1.00
74_L 90_W 2.58 1.00
314_R 373_L 2.568 1.00
386_T 417_K 2.559 1.00
314_R 317_T 2.557 1.00
469_S 502_D 2.549 1.00
114_V 214_N 2.519 1.00
469_S 498_Q 2.503 1.00
163_K 173_T 2.424 1.00
97_V 171_E 2.385 1.00
97_V 173_T 2.379 1.00
123_W 172_V 2.352 1.00
484_D 487_Q 2.343 1.00
99_T 171_E 2.341 1.00
77_D 83_A 2.34 1.00
409_K 415_N 2.336 1.00
195_K 199_E 2.331 1.00
218_T 234_P 2.324 1.00
471_A 494_K 2.321 1.00
88_E 104_K 2.32 1.00
101_H 169_T 2.311 1.00
106_A 114_V 2.292 1.00
107_K 113_P 2.255 1.00
92_N 96_K 2.248 1.00
109_S 233_S 2.246 1.00
478_E 491_L 2.216 1.00
107_K 235_T 2.207 1.00
119_F 170_L 2.178 1.00
458_S 473_D 2.154 1.00
229_V 246_Q 2.144 1.00
388_N 417_K 2.133 1.00
490_A 494_K 2.128 1.00
217_Y 244_I 2.099 1.00
388_N 419_V 2.076 1.00
458_S 468_K 2.071 1.00
317_T 369_E 2.057 1.00
303_I 506_V 2.025 1.00
307_K 436_D 2.025 1.00
115_T 118_D 1.993 1.00
53_D 125_R 1.964 1.00
71_E 85_G 1.963 1.00
472_F 495_A 1.955 1.00
105_D 113_P 1.952 1.00
497_Q 501_K 1.949 1.00
475_I 494_K 1.907 1.00
117_Q 195_K 1.907 1.00
319_L 414_V 1.884 1.00
117_Q 167_D 1.877 1.00
303_I 437_V 1.872 1.00
117_Q 120_V 1.871 1.00
223_V 226_E 1.86 1.00
261_R 266_E 1.858 1.00
221_D 229_V 1.848 1.00
112_T 196_A 1.841 1.00
479_T 492_Y 1.83 1.00
88_E 101_H 1.81 1.00
231_E 246_Q 1.797 1.00
90_W 100_F 1.774 1.00
491_L 494_K 1.774 1.00
479_T 491_L 1.77 1.00
494_K 497_Q 1.75 1.00
320_K 503_S 1.733 1.00
118_D 195_K 1.733 1.00
232_R 245_N 1.724 1.00
340_A 510_Y 1.721 1.00
405_S 409_K 1.721 1.00
470_P 474_S 1.718 1.00
221_D 227_R 1.714 1.00
263_R 281_K 1.708 1.00
40_T 248_T 1.7 1.00
40_T 246_Q 1.687 1.00
74_L 100_F 1.68 1.00
323_M 404_A 1.679 1.00
313_V 502_D 1.674 1.00
110_D 194_P 1.664 1.00
59_G 62_E 1.663 1.00
371_K 375_A 1.66 1.00
310_F 319_L 1.66 1.00
310_F 387_I 1.651 1.00
478_E 487_Q 1.645 1.00
116_A 164_A 1.64 1.00
44_N 267_I 1.636 1.00
220_K 246_Q 1.629 1.00
471_A 498_Q 1.601 1.00
223_V 227_R 1.592 1.00
368_E 371_K 1.591 1.00
475_I 491_L 1.585 1.00
115_T 167_D 1.584 1.00
322_G 412_I 1.58 1.00
106_A 214_N 1.566 1.00
109_S 218_T 1.565 1.00
490_A 493_T 1.564 1.00
428_D 432_Q 1.556 1.00
468_K 473_D 1.553 1.00
315_V 377_A 1.551 1.00
194_P 197_A 1.548 1.00
88_E 103_R 1.545 1.00
99_T 169_T 1.543 1.00
315_V 374_L 1.538 1.00
161_G 173_T 1.538 1.00
487_Q 491_L 1.535 1.00
252_I 261_R 1.525 1.00
227_R 248_T 1.507 1.00
306_Q 466_H 1.498 1.00
172_V 181_F 1.49 1.00
429_T 434_T 1.49 1.00
42_V 248_T 1.475 1.00
373_L 376_E 1.471 1.00
112_T 194_P 1.47 1.00
165_I 169_T 1.462 1.00
317_T 503_S 1.445 1.00
313_V 501_K 1.441 1.00
422_E 425_T 1.44 1.00
280_Q 283_K 1.436 1.00
113_P 168_H 1.432 1.00
375_A 380_T 1.43 1.00
71_E 214_N 1.425 1.00
489_T 493_T 1.422 1.00
384_P 415_N 1.419 1.00
103_R 106_A 1.414 1.00
39_Q 245_N 1.413 1.00
498_Q 502_D 1.406 0.99
229_V 248_T 1.396 0.99
101_H 168_H 1.388 0.99
98_W 181_F 1.383 0.99
482_V 491_L 1.381 0.99
92_N 95_A 1.375 0.99
261_R 267_I 1.371 0.99
164_A 167_D 1.359 0.99
71_E 237_W 1.358 0.99
287_P 519_P 1.357 0.99
372_K 375_A 1.354 0.99
92_N 99_T 1.35 0.99
448_E 488_R 1.347 0.99
475_I 498_Q 1.347 0.99
107_K 233_S 1.337 0.99
326_D 339_P 1.332 0.99
398_K 402_I 1.331 0.99
92_N 97_V 1.325 0.99
289_E 519_P 1.319 0.99
230_L 249_Y 1.315 0.99
116_A 165_I 1.315 0.99
232_R 242_T 1.308 0.99
120_V 162_V 1.289 0.99
231_E 234_P 1.277 0.99
101_H 104_K 1.273 0.99
366_R 369_E 1.269 0.99
268_D 518_K 1.259 0.99
109_S 235_T 1.253 0.99
467_Y 472_F 1.253 0.99
329_V 339_P 1.25 0.99
433_G 466_H 1.246 0.98
257_T 261_R 1.243 0.98
407_L 410_K 1.236 0.98
368_E 372_K 1.23 0.98
109_S 219_L 1.223 0.98
317_T 373_L 1.217 0.98
419_V 429_T 1.213 0.98
238_N 241_K 1.213 0.98
101_H 166_D 1.212 0.98
307_K 311_N 1.21 0.98
367_N 412_I 1.208 0.98
471_A 475_I 1.184 0.98
220_K 229_V 1.179 0.98
475_I 478_E 1.178 0.98
474_S 477_A 1.178 0.98
389_L 416_V 1.175 0.98
145_A 175_S 1.172 0.98
84_P 90_W 1.161 0.97
88_E 168_H 1.159 0.97
478_E 494_K 1.154 0.97
367_N 371_K 1.153 0.97
145_A 173_T 1.151 0.97
48_E 222_W 1.148 0.97
176_E 481_K 1.147 0.97
196_A 200_K 1.141 0.97
262_Y 516_L 1.138 0.97
391_Y 418_L 1.134 0.97
478_E 482_V 1.134 0.97
303_I 319_L 1.134 0.97
100_F 172_V 1.133 0.97
119_F 192_P 1.131 0.97
403_A 407_L 1.113 0.96
387_I 437_V 1.112 0.96
86_V 214_N 1.108 0.96
313_V 503_S 1.105 0.96
99_T 165_I 1.104 0.96
110_D 196_A 1.099 0.96
75_V 85_G 1.099 0.96
405_S 418_L 1.097 0.96
75_V 83_A 1.096 0.96
423_W 427_L 1.096 0.96
98_W 182_Y 1.091 0.96
91_D 99_T 1.091 0.96
113_P 167_D 1.089 0.96
162_V 170_L 1.084 0.96
522_G 541_V 1.083 0.96
327_I 407_L 1.081 0.95
467_Y 504_A 1.08 0.95
103_R 237_W 1.072 0.95
486_A 489_T 1.071 0.95
72_G 85_G 1.065 0.95
42_V 250_L 1.058 0.95
346_P 510_Y 1.057 0.95
408_W 416_V 1.057 0.95
404_A 408_W 1.054 0.95
406_S 410_K 1.049 0.94
232_R 241_K 1.048 0.94
486_A 490_A 1.047 0.94
292_V 512_V 1.045 0.94
322_G 408_W 1.044 0.94
320_K 325_R 1.041 0.94
328_I 400_L 1.041 0.94
218_T 233_S 1.037 0.94
387_I 416_V 1.036 0.94
118_D 121_Y 1.033 0.94
268_D 520_W 1.021 0.93
120_V 170_L 1.02 0.93
174_L 181_F 1.019 0.93
124_Q 164_A 1.019 0.93
302_E 438_A 1.018 0.93
289_E 517_V 1.011 0.93
164_A 171_E 1.01 0.93
314_R 377_A 1.009 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3o9pA10.9541000.132Contact Map0.744
4fajA10.97241000.138Contact Map0.739
3zs6A10.92821000.141Contact Map0.763
1jetA10.95031000.142Contact Map0.808
4gl8A20.96321000.157Contact Map0.804
1xocA10.90611000.18Contact Map0.759
1uqwA20.91341000.192Contact Map0.78
3drfA10.93191000.192Contact Map0.693
3m8uA10.90061000.193Contact Map0.79
1dpeA10.89321000.197Contact Map0.793
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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