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OPENSEQ.org
YGFQ - Putative permease YgfQ
UniProt: Q46817 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13067
Length: 455 (433)
Sequences: 1465
Seq/Len: 3.38
YGFQ
Paralog alert: 0.45 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: PURP YGFQ YICO YJCD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
24_I 29_S 3.852 1.00
173_N 181_A 3.822 1.00
82_G 344_T 3.79 1.00
23_K 26_A 3.655 1.00
77_G 311_S 3.373 1.00
285_V 333_T 3.275 1.00
422_V 442_T 3.165 1.00
31_V 341_L 3.076 1.00
58_K 103_F 3.024 1.00
35_V 345_V 2.997 1.00
337_G 342_T 2.95 1.00
24_I 341_L 2.882 1.00
79_L 347_G 2.852 1.00
19_D 25_T 2.804 1.00
37_A 337_G 2.722 1.00
399_V 420_T 2.679 1.00
125_V 129_A 2.518 1.00
24_I 31_V 2.474 1.00
430_E 433_K 2.471 1.00
89_M 325_V 2.362 1.00
253_L 317_L 2.346 1.00
75_G 351_L 2.313 1.00
49_V 71_C 2.272 1.00
212_I 371_A 2.259 1.00
293_D 297_Q 2.254 1.00
434_L 439_V 2.238 1.00
90_A 346_V 2.204 1.00
425_R 433_K 2.149 1.00
167_V 193_S 2.137 1.00
35_V 39_L 2.125 1.00
348_A 352_L 2.11 1.00
197_L 373_M 2.098 1.00
27_R 339_T 2.073 1.00
37_A 342_T 2.055 1.00
30_T 33_Q 2.031 1.00
383_V 401_A 2.001 1.00
78_S 347_G 1.996 1.00
192_M 219_I 1.988 1.00
23_K 86_N 1.931 1.00
204_E 378_L 1.929 1.00
118_G 255_I 1.916 1.00
165_N 179_P 1.909 1.00
161_L 406_L 1.906 1.00
214_L 218_A 1.901 1.00
201_F 395_M 1.894 1.00
195_L 222_I 1.894 1.00
79_L 344_T 1.887 1.00
105_L 270_L 1.853 0.99
391_F 395_M 1.84 0.99
200_I 215_V 1.823 0.99
114_P 252_S 1.815 0.99
75_G 79_L 1.79 0.99
236_V 356_L 1.764 0.99
79_L 83_L 1.738 0.99
199_V 218_A 1.733 0.99
163_A 373_M 1.708 0.99
146_G 393_D 1.704 0.99
202_G 427_F 1.701 0.99
49_V 353_I 1.688 0.99
35_V 349_L 1.668 0.99
95_I 98_T 1.656 0.98
87_L 298_I 1.652 0.98
251_F 317_L 1.651 0.98
241_L 247_K 1.651 0.98
345_V 348_A 1.644 0.98
431_W 439_V 1.642 0.98
161_L 180_V 1.637 0.98
76_F 318_V 1.627 0.98
137_T 141_R 1.622 0.98
203_L 208_V 1.621 0.98
50_I 361_F 1.591 0.98
172_K 179_P 1.584 0.98
196_G 219_I 1.581 0.98
165_N 408_C 1.55 0.97
431_W 434_L 1.55 0.97
170_V 407_T 1.536 0.97
287_G 385_K 1.526 0.97
21_Y 86_N 1.522 0.97
426_V 431_W 1.521 0.97
33_Q 37_A 1.506 0.97
19_D 24_I 1.503 0.97
386_L 394_A 1.502 0.97
364_P 367_A 1.499 0.97
118_G 258_A 1.497 0.97
128_T 313_I 1.494 0.96
426_V 439_V 1.488 0.96
52_V 98_T 1.478 0.96
80_L 84_W 1.469 0.96
195_L 199_V 1.462 0.96
24_I 86_N 1.433 0.95
58_K 102_A 1.433 0.95
254_D 257_G 1.428 0.95
76_F 314_F 1.428 0.95
346_V 353_I 1.421 0.95
18_L 21_Y 1.408 0.95
57_G 63_P 1.404 0.94
392_I 428_A 1.401 0.94
341_L 344_T 1.4 0.94
203_L 214_L 1.392 0.94
75_G 347_G 1.389 0.94
112_S 115_V 1.386 0.94
80_L 307_S 1.385 0.94
48_S 52_V 1.383 0.94
255_I 258_A 1.38 0.94
61_F 113_V 1.375 0.94
288_Q 334_A 1.373 0.94
221_I 225_I 1.371 0.94
18_L 31_V 1.37 0.93
292_L 298_I 1.364 0.93
200_I 374_Y 1.362 0.93
274_A 322_P 1.357 0.93
184_A 187_S 1.336 0.92
74_A 92_G 1.333 0.92
393_D 425_R 1.332 0.92
202_G 423_V 1.328 0.92
39_L 349_L 1.327 0.92
392_I 425_R 1.325 0.92
191_M 195_L 1.324 0.92
205_K 395_M 1.322 0.92
402_V 406_L 1.322 0.92
384_S 389_N 1.31 0.91
192_M 223_G 1.309 0.91
21_Y 83_L 1.293 0.91
94_A 324_A 1.288 0.90
400_C 417_G 1.278 0.90
313_I 316_G 1.276 0.90
220_S 363_I 1.263 0.89
59_A 66_V 1.259 0.89
73_V 323_A 1.254 0.89
204_E 211_G 1.25 0.89
278_A 325_V 1.246 0.88
200_I 204_E 1.245 0.88
123_M 274_A 1.244 0.88
300_N 303_K 1.244 0.88
435_N 439_V 1.242 0.88
71_C 75_G 1.239 0.88
423_V 427_F 1.239 0.88
35_V 348_A 1.237 0.88
87_L 300_N 1.225 0.87
201_F 424_G 1.22 0.87
204_E 374_Y 1.219 0.87
121_F 253_L 1.213 0.87
202_G 428_A 1.208 0.86
196_G 370_P 1.199 0.86
45_M 90_A 1.191 0.85
136_R 308_D 1.182 0.85
17_A 21_Y 1.18 0.84
52_V 70_T 1.18 0.84
199_V 222_I 1.177 0.84
35_V 341_L 1.173 0.84
164_A 373_M 1.172 0.84
291_L 325_V 1.169 0.84
19_D 341_L 1.162 0.83
222_I 226_F 1.16 0.83
61_F 66_V 1.147 0.82
312_S 322_P 1.143 0.82
376_G 398_L 1.142 0.82
128_T 309_S 1.142 0.82
200_I 212_I 1.133 0.81
52_V 55_M 1.132 0.81
192_M 222_I 1.128 0.81
153_I 383_V 1.126 0.80
209_P 335_A 1.126 0.80
422_V 434_L 1.113 0.79
150_G 386_L 1.111 0.79
19_D 31_V 1.102 0.78
309_S 313_I 1.098 0.78
125_V 313_I 1.097 0.78
205_K 391_F 1.087 0.77
78_S 344_T 1.086 0.77
403_F 416_L 1.082 0.77
131_S 306_T 1.082 0.77
161_L 165_N 1.082 0.77
82_G 347_G 1.08 0.76
102_A 107_L 1.072 0.76
241_L 248_S 1.065 0.75
57_G 66_V 1.058 0.74
50_I 363_I 1.051 0.74
160_L 398_L 1.05 0.74
45_M 326_Y 1.049 0.73
128_T 306_T 1.047 0.73
426_V 434_L 1.045 0.73
314_F 317_L 1.037 0.72
344_T 348_A 1.036 0.72
130_I 271_V 1.033 0.72
399_V 416_L 1.03 0.71
174_P 177_G 1.028 0.71
216_I 367_A 1.027 0.71
137_T 302_G 1.025 0.71
151_T 272_M 1.024 0.71
403_F 407_T 1.023 0.71
150_G 400_C 1.02 0.70
250_I 317_L 1.016 0.70
294_K 297_Q 1.011 0.69
33_Q 209_P 1.01 0.69
104_S 108_G 1.009 0.69
199_V 215_V 1.009 0.69
87_L 304_A 1.008 0.69
89_M 291_L 1.005 0.69
210_G 330_A 1.003 0.69
149_H 385_K 1.001 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A10.85931000.679Contact Map0.4
4fixA20.13194.80.986Contact Map0.33
2e8pA10.06154.60.986Contact Map0.134
3o7qA10.43084.40.986Contact Map0.374
1sxdA10.076940.987Contact Map0.291
1x66A10.07473.30.987Contact Map0.091
1sv0C20.07253.20.987Contact Map0.209
2jv3A10.07473.10.987Contact Map0.124
1sxeA10.07472.50.988Contact Map0.166
2k9pA10.14952.50.988Contact Map0.032
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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