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OPENSEQ.org
PURP - Probable adenine permease PurP
UniProt: P31466 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11724
Length: 445 (429)
Sequences: 1455
Seq/Len: 3.39
PURP
Paralog alert: 0.45 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: PURP YGFQ YICO YJCD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
21_L 26_T 3.731 1.00
170_N 176_S 3.728 1.00
79_G 334_V 3.648 1.00
20_K 23_E 3.603 1.00
74_G 301_S 3.342 1.00
275_V 323_V 3.296 1.00
412_C 432_A 3.048 1.00
28_A 331_L 3.038 1.00
55_V 100_F 3.011 1.00
327_G 332_T 2.953 1.00
32_V 335_V 2.943 1.00
21_L 331_L 2.901 1.00
16_E 22_R 2.869 1.00
76_I 337_G 2.727 1.00
34_A 327_G 2.699 1.00
389_I 410_S 2.641 1.00
122_I 126_L 2.553 1.00
420_R 423_D 2.55 1.00
21_L 28_A 2.483 1.00
86_V 315_A 2.391 1.00
243_V 307_F 2.36 1.00
72_A 341_L 2.263 1.00
424_L 429_I 2.243 1.00
207_V 361_A 2.237 1.00
46_V 68_C 2.231 1.00
87_A 336_V 2.219 1.00
283_D 287_K 2.151 1.00
192_F 363_I 2.124 1.00
415_K 423_D 2.082 1.00
32_V 36_F 2.078 1.00
24_H 329_T 2.066 1.00
34_A 332_T 2.054 1.00
164_A 188_G 2.054 1.00
115_G 245_L 2.053 1.00
338_L 342_L 2.049 1.00
75_S 337_G 2.004 1.00
111_Q 242_H 2 1.00
190_L 217_L 1.972 1.00
27_T 30_T 1.96 1.00
373_L 391_A 1.949 1.00
20_K 83_N 1.94 1.00
76_I 334_V 1.939 1.00
187_L 214_T 1.933 1.00
162_K 174_L 1.896 1.00
196_A 385_V 1.871 0.99
158_M 396_F 1.869 0.99
381_L 385_V 1.841 0.99
199_A 368_L 1.831 0.99
102_V 260_F 1.826 0.99
209_V 213_V 1.811 0.99
195_I 210_S 1.806 0.99
76_I 80_L 1.787 0.99
72_A 76_I 1.736 0.99
160_G 363_I 1.726 0.99
46_V 343_V 1.702 0.99
230_V 346_L 1.661 0.98
194_I 213_V 1.661 0.98
32_V 339_L 1.66 0.98
84_L 288_F 1.659 0.98
92_M 95_N 1.657 0.98
73_F 308_I 1.65 0.98
191_G 214_T 1.65 0.98
134_Y 138_A 1.638 0.98
421_L 429_I 1.634 0.98
162_K 398_F 1.631 0.98
18_V 83_N 1.63 0.98
143_S 383_E 1.624 0.98
158_M 175_V 1.609 0.98
376_V 384_S 1.589 0.98
197_I 417_G 1.587 0.98
421_L 424_L 1.571 0.98
335_V 338_L 1.57 0.98
169_A 174_L 1.554 0.97
277_D 375_R 1.542 0.97
198_L 203_I 1.528 0.97
55_V 99_A 1.525 0.97
241_G 307_F 1.524 0.97
167_I 397_S 1.524 0.97
47_F 351_G 1.517 0.97
190_L 194_I 1.514 0.97
198_L 209_V 1.512 0.97
16_E 21_L 1.511 0.97
77_M 81_F 1.501 0.97
416_I 421_L 1.497 0.97
115_G 248_S 1.491 0.96
30_T 34_A 1.488 0.96
354_P 357_A 1.471 0.96
125_L 303_V 1.467 0.96
336_V 343_V 1.466 0.96
73_F 304_T 1.463 0.96
49_N 95_N 1.437 0.95
21_L 83_N 1.429 0.95
15_L 28_A 1.426 0.95
416_I 429_I 1.423 0.95
413_V 417_G 1.415 0.95
15_L 18_V 1.41 0.95
216_L 220_M 1.401 0.94
71_A 89_A 1.388 0.94
282_A 288_F 1.387 0.94
58_M 110_W 1.377 0.94
45_I 49_N 1.376 0.94
72_A 337_G 1.373 0.94
278_K 324_S 1.37 0.94
392_V 396_F 1.37 0.94
235_S 238_T 1.367 0.93
77_M 297_V 1.362 0.93
390_T 407_G 1.36 0.93
195_I 364_Y 1.356 0.93
187_L 218_G 1.354 0.93
264_N 312_S 1.349 0.93
244_D 247_G 1.347 0.93
54_G 60_T 1.337 0.92
196_A 414_M 1.33 0.92
32_V 338_L 1.327 0.92
36_F 339_L 1.319 0.92
179_N 182_S 1.317 0.92
382_T 418_T 1.315 0.92
109_P 112_V 1.314 0.92
374_A 379_Q 1.307 0.91
382_T 415_K 1.304 0.91
245_L 248_S 1.295 0.91
118_F 243_V 1.293 0.91
197_I 413_V 1.284 0.90
331_L 334_V 1.284 0.90
186_L 190_L 1.279 0.90
268_S 315_A 1.271 0.90
383_E 415_K 1.269 0.90
425_S 429_I 1.264 0.89
195_I 199_A 1.262 0.89
70_I 313_V 1.26 0.89
290_R 293_Q 1.255 0.89
91_A 314_T 1.239 0.88
120_G 264_N 1.233 0.88
199_A 364_Y 1.232 0.88
194_I 217_L 1.228 0.87
215_T 353_V 1.226 0.87
84_L 290_R 1.225 0.87
199_A 206_A 1.222 0.87
217_L 221_L 1.222 0.87
68_C 72_A 1.219 0.87
303_V 306_S 1.214 0.87
231_S 234_P 1.205 0.86
42_M 87_A 1.205 0.86
197_I 418_T 1.201 0.86
14_M 18_V 1.2 0.86
200_S 385_V 1.197 0.86
158_M 162_K 1.194 0.85
281_L 315_A 1.187 0.85
32_V 331_L 1.181 0.85
191_G 360_G 1.173 0.84
133_R 298_D 1.172 0.84
161_L 363_I 1.17 0.84
436_I 440_V 1.159 0.83
366_G 388_F 1.143 0.82
56_A 63_V 1.143 0.82
412_C 424_L 1.139 0.82
195_I 207_V 1.138 0.81
193_F 413_V 1.136 0.81
58_M 63_V 1.135 0.81
302_S 312_S 1.127 0.81
16_E 331_L 1.125 0.80
49_N 52_I 1.122 0.80
49_N 67_T 1.122 0.80
79_G 337_G 1.114 0.79
122_I 303_V 1.104 0.79
147_G 376_V 1.1 0.78
299_S 303_V 1.099 0.78
15_L 331_L 1.098 0.78
204_H 325_V 1.096 0.78
18_V 80_L 1.093 0.78
389_I 406_L 1.09 0.77
125_L 299_S 1.088 0.77
393_M 406_L 1.088 0.77
16_E 28_A 1.086 0.77
187_L 217_L 1.08 0.76
416_I 424_L 1.07 0.76
284_E 287_K 1.061 0.75
128_T 296_Y 1.058 0.74
150_S 373_L 1.058 0.74
304_T 307_F 1.054 0.74
42_M 316_Y 1.049 0.74
134_Y 292_K 1.047 0.73
125_L 296_Y 1.046 0.73
127_L 261_M 1.037 0.72
215_T 352_M 1.033 0.72
84_L 294_A 1.031 0.72
47_F 353_V 1.03 0.72
103_V 107_G 1.026 0.71
54_G 63_V 1.024 0.71
157_G 388_F 1.023 0.71
334_V 338_L 1.021 0.71
146_V 375_R 1.016 0.70
147_G 390_T 1.015 0.70
148_I 262_L 1.012 0.70
218_G 224_V 1.012 0.70
264_N 302_S 1.01 0.69
415_K 420_R 1.007 0.69
86_V 281_L 1.003 0.69
99_A 104_Q 1.003 0.69
118_F 306_S 1.001 0.68
200_S 381_L 1.001 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A10.87191000.675Contact Map0.403
3o7qA10.43155.30.986Contact Map0.372
2gfpA20.43374.40.986Contact Map0.138
3r3tA20.06972.40.988Contact Map0.066
2ls3A10.06291.90.989Contact Map1
2pg1I40.02471.80.989Contact Map
3fm7C20.02251.80.989Contact Map
3glwZ10.0271.60.989Contact Map
3piwA10.12131.60.989Contact Map0.504
4f35D40.54611.50.989Contact Map0.121
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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