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OPENSEQ.org
ALLD - Ureidoglycolate dehydrogenase
UniProt: P77555 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13624
Length: 349 (341)
Sequences: 916
Seq/Len: 2.69
ALLD
Paralog alert: 0.57 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ALLD DLGD YBIC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
81_A 89_A 3.847 1.00
124_V 160_A 3.704 1.00
315_K 319_E 3.226 1.00
291_N 307_Q 3.119 1.00
68_R 82_D 3.105 1.00
149_G 293_I 3.049 1.00
200_A 214_V 3.009 1.00
9_H 31_E 2.585 1.00
325_D 329_Q 2.365 1.00
94_M 127_A 2.342 1.00
194_S 211_P 2.315 1.00
210_D 213_A 2.286 1.00
74_P 104_N 2.28 1.00
295_P 302_V 2.273 1.00
151_E 294_T 2.27 1.00
62_N 82_D 2.252 1.00
95_E 126_Q 2.239 1.00
194_S 209_T 2.237 1.00
128_A 162_A 2.236 1.00
298_G 301_Q 2.153 1.00
72_T 100_T 2.081 1.00
102_Q 130_A 2.063 1.00
99_K 103_Q 2.034 1.00
42_H 316_A 1.966 0.99
65_P 82_D 1.945 0.99
70_E 80_H 1.939 0.99
97_A 107_A 1.919 0.99
77_A 109_V 1.91 0.99
16_L 49_V 1.905 0.99
117_S 136_S 1.898 0.99
161_F 231_M 1.894 0.99
145_V 216_A 1.889 0.99
75_C 104_N 1.887 0.99
44_H 116_H 1.883 0.99
110_G 240_L 1.859 0.99
156_T 177_T 1.859 0.99
162_A 172_T 1.85 0.99
181_A 184_K 1.827 0.99
17_C 23_R 1.789 0.99
8_L 46_A 1.773 0.99
77_A 97_A 1.728 0.98
48_R 183_G 1.724 0.98
30_A 34_V 1.709 0.98
316_A 322_E 1.694 0.98
38_A 316_A 1.68 0.98
117_S 120_I 1.67 0.98
13_E 27_A 1.669 0.98
269_N 272_F 1.665 0.98
202_D 206_V 1.65 0.97
202_D 213_A 1.643 0.97
74_P 100_T 1.638 0.97
145_V 201_V 1.629 0.97
201_V 216_A 1.625 0.97
180_Q 199_W 1.622 0.97
297_P 301_Q 1.62 0.97
173_F 227_G 1.617 0.97
97_A 109_V 1.597 0.97
37_D 42_H 1.593 0.97
132_F 270_P 1.552 0.96
10_Q 14_N 1.533 0.95
134_G 162_A 1.527 0.95
102_Q 132_F 1.525 0.95
195_I 199_W 1.52 0.95
314_R 318_V 1.515 0.95
151_E 293_I 1.51 0.95
29_V 85_A 1.503 0.95
127_A 267_V 1.498 0.95
62_N 65_P 1.493 0.95
116_H 183_G 1.47 0.94
96_H 99_K 1.469 0.94
5_R 38_A 1.416 0.92
25_H 88_V 1.409 0.92
143_M 182_W 1.402 0.92
135_I 266_I 1.4 0.92
125_Q 129_R 1.391 0.91
70_E 78_I 1.374 0.91
200_A 208_T 1.365 0.90
114_M 263_Q 1.365 0.90
291_N 301_Q 1.361 0.90
77_A 107_A 1.346 0.89
13_E 23_R 1.344 0.89
98_I 130_A 1.34 0.89
313_Q 317_A 1.337 0.89
189_R 212_F 1.332 0.89
13_E 17_C 1.329 0.89
90_A 265_H 1.324 0.88
65_P 84_A 1.324 0.88
301_Q 311_I 1.315 0.88
96_H 100_T 1.296 0.87
80_H 113_R 1.281 0.86
159_L 232_I 1.266 0.85
108_V 266_I 1.262 0.85
178_T 229_M 1.255 0.84
324_V 327_I 1.249 0.84
32_V 87_Q 1.244 0.84
163_A 231_M 1.24 0.83
14_N 17_C 1.238 0.83
15_K 53_A 1.216 0.82
73_G 272_F 1.21 0.81
197_D 209_T 1.202 0.81
9_H 13_E 1.19 0.80
154_Y 229_M 1.186 0.80
67_F 82_D 1.186 0.80
43_S 184_K 1.178 0.79
31_E 122_Y 1.177 0.79
107_A 267_V 1.177 0.79
96_H 109_V 1.175 0.79
57_S 344_K 1.173 0.79
188_A 195_I 1.172 0.78
146_P 226_Y 1.171 0.78
169_E 314_R 1.171 0.78
297_P 300_N 1.167 0.78
8_L 321_I 1.167 0.78
77_A 96_H 1.166 0.78
94_M 126_Q 1.166 0.78
144_V 216_A 1.164 0.78
195_I 200_A 1.162 0.78
81_A 111_I 1.161 0.78
12_I 49_V 1.151 0.77
159_L 228_L 1.15 0.77
185_V 214_V 1.149 0.77
288_R 292_A 1.135 0.75
39_R 313_Q 1.128 0.75
28_T 91_K 1.123 0.74
48_R 116_H 1.123 0.74
94_M 134_G 1.123 0.74
80_H 112_S 1.121 0.74
76_S 273_F 1.116 0.74
175_M 228_L 1.114 0.73
95_E 99_K 1.112 0.73
44_H 183_G 1.106 0.73
262_G 279_F 1.102 0.72
144_V 177_T 1.094 0.71
165_G 284_S 1.091 0.71
307_Q 310_D 1.084 0.70
23_R 27_A 1.078 0.70
31_E 323_I 1.071 0.69
26_A 30_A 1.066 0.69
208_T 214_V 1.062 0.68
236_S 262_G 1.06 0.68
22_K 25_H 1.056 0.68
12_I 16_L 1.054 0.67
77_A 100_T 1.054 0.67
270_P 275_S 1.051 0.67
98_I 101_A 1.045 0.66
16_L 29_V 1.04 0.66
108_V 273_F 1.04 0.66
43_S 116_H 1.039 0.66
153_Y 289_E 1.033 0.65
163_A 279_F 1.027 0.64
46_A 323_I 1.023 0.64
52_Y 118_G 1.02 0.64
91_K 126_Q 1.02 0.64
167_G 284_S 1.016 0.63
291_N 302_V 1.016 0.63
132_F 267_V 1.006 0.62
340_S 343_T 1.004 0.62
117_S 263_Q 1.003 0.62
243_P 260_N 1.001 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vbiA10.97131000.039Contact Map0.651
4h8aA20.96561000.04Contact Map0.739
1z2iA40.97711000.041Contact Map0.736
3i0pA10.97711000.043Contact Map0.708
1v9nA10.96851000.047Contact Map0.713
3uoeA20.95131000.049Contact Map0.724
1rfmA80.95991000.049Contact Map0.808
1nxuA20.94561000.06Contact Map0.75
2g8yA20.96281000.06Contact Map0.747
1wtjA20.94271000.062Contact Map0.717
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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