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PTFB2 - Fructose-like phosphotransferase enzyme IIB component 2
UniProt: P69816 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11909
Length: 106 (102)
Sequences: 904
Seq/Len: 8.86

PTFB2
Paralog alert: 0.61 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: PTFB1 PTFB2 PTFB3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
36_K 53_D 3.445 1.00
52_E 56_S 3.355 1.00
5_I 60_V 3.215 1.00
31_K 96_S 3.076 1.00
51_A 55_A 2.943 1.00
24_L 35_V 2.663 1.00
6_A 37_V 2.634 1.00
31_K 92_D 2.593 1.00
45_L 48_E 2.444 1.00
30_A 92_D 2.329 1.00
90_R 93_A 2.282 1.00
92_D 96_S 2.241 1.00
28_A 35_V 2.145 1.00
86_D 90_R 2.14 1.00
69_K 72_E 2.038 1.00
59_M 98_I 2.023 1.00
3_K 56_S 1.999 1.00
3_K 34_E 1.867 1.00
25_E 29_K 1.855 1.00
21_A 25_E 1.853 1.00
49_L 54_V 1.839 1.00
36_K 47_N 1.78 1.00
27_A 30_A 1.765 1.00
27_A 31_K 1.723 1.00
3_K 58_D 1.516 1.00
39_T 47_N 1.487 1.00
71_E 81_R 1.383 0.99
22_E 25_E 1.381 0.99
7_V 40_Q 1.299 0.99
33_W 95_M 1.268 0.98
26_S 29_K 1.228 0.98
9_A 66_I 1.225 0.98
84_I 87_A 1.198 0.97
85_S 89_K 1.197 0.97
9_A 40_Q 1.173 0.97
60_V 77_K 1.159 0.97
50_T 53_D 1.142 0.96
27_A 92_D 1.14 0.96
43_I 46_E 1.096 0.95
21_A 47_N 1.073 0.94
18_Y 46_E 1.072 0.94
80_V 94_I 1.072 0.94
5_I 49_L 1.063 0.94
27_A 91_A 1.061 0.94
18_Y 84_I 1.036 0.93
48_E 70_F 1.014 0.91
54_V 77_K 1 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2r48A10.99061000.155Contact Map0.841
2kyrA111000.318Contact Map0.658
2r4qA10.99061000.331Contact Map0.786
2m1zA10.99061000.355Contact Map0.635
4mgeA20.905799.70.591Contact Map0.557
1e2bA10.924599.70.613Contact Map0.469
2l2qA10.915199.60.644Contact Map0.361
3czcA10.867998.80.748Contact Map0.389
1tvmA10.877498.70.761Contact Map0.241
1vkrA10.877498.10.796Contact Map0.438

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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