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PTFB1 - Fructose-like phosphotransferase enzyme IIB component 1
UniProt: P69808 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14155
Length: 108 (104)
Sequences: 935
Seq/Len: 8.99

PTFB1
Paralog alert: 0.61 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: PTFB1 PTFB2 PTFB3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
37_K 54_D 3.365 1.00
53_Q 57_E 3.364 1.00
6_I 61_I 3.183 1.00
32_A 97_K 2.955 1.00
52_A 56_A 2.902 1.00
25_L 36_V 2.615 1.00
32_A 93_A 2.595 1.00
7_A 38_I 2.55 1.00
46_I 49_R 2.398 1.00
91_N 94_G 2.376 1.00
93_A 97_K 2.334 1.00
31_E 93_A 2.249 1.00
60_I 99_I 2.224 1.00
29_A 36_V 2.166 1.00
87_D 91_N 2.137 1.00
70_E 73_E 2.043 1.00
4_K 57_E 1.95 1.00
4_K 35_E 1.929 1.00
26_E 30_V 1.86 1.00
22_A 26_E 1.823 1.00
28_A 32_A 1.792 1.00
50_L 55_I 1.769 1.00
28_A 31_E 1.762 1.00
37_K 48_N 1.737 1.00
40_T 48_N 1.418 0.99
72_N 82_E 1.393 0.99
97_K 101_E 1.387 0.99
34_Y 96_I 1.334 0.99
23_Q 26_E 1.33 0.99
8_L 41_Q 1.327 0.99
4_K 59_T 1.254 0.98
85_L 88_A 1.254 0.98
86_Q 90_K 1.252 0.98
27_E 30_V 1.226 0.98
10_A 67_V 1.22 0.98
51_T 54_D 1.208 0.98
61_I 78_R 1.199 0.97
10_A 41_Q 1.18 0.97
19_F 47_Q 1.134 0.96
49_R 71_D 1.107 0.95
28_A 92_A 1.086 0.95
28_A 93_A 1.06 0.94
44_D 47_Q 1.059 0.94
22_A 48_N 1.043 0.93
19_F 85_L 1.033 0.93
81_Y 95_I 1.032 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2r48A10.97221000.154Contact Map0.828
2kyrA111000.295Contact Map0.666
2r4qA10.97221000.327Contact Map0.781
2m1zA10.98151000.339Contact Map0.622
4mgeA20.898199.70.59Contact Map0.543
1e2bA10.925999.70.606Contact Map0.48
2l2qA10.907499.60.641Contact Map0.352
3czcA10.851998.80.747Contact Map0.388
1tvmA10.870498.60.761Contact Map0.246
1vkrA10.879698.10.795Contact Map0.437

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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