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OPENSEQ.org
GUAC - GMP reductase
UniProt: P60560 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10422
Length: 347 (335)
Sequences: 1821
Seq/Len: 5.44
GUAC
Paralog alert: 0.56 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: GUAC IMDH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_A 100_M 4.528 1.00
323_R 326_E 4.444 1.00
38_K 153_T 4.329 1.00
229_A 315_A 3.753 1.00
81_V 115_Q 3.384 1.00
166_E 170_L 2.934 1.00
136_E 140_Q 2.934 1.00
7_L 335_R 2.914 1.00
208_A 211_G 2.872 1.00
114_K 118_D 2.855 1.00
232_F 312_L 2.812 1.00
34_Q 40_S 2.797 1.00
237_D 328_T 2.695 1.00
32_E 40_S 2.611 1.00
326_E 330_R 2.444 1.00
146_R 154_I 2.355 1.00
166_E 208_A 2.349 1.00
159_V 165_C 2.345 1.00
80_S 83_E 2.338 1.00
22_T 136_E 2.269 1.00
322_S 326_E 2.242 1.00
165_C 205_C 2.216 1.00
62_M 301_V 2.211 1.00
20_R 136_E 2.177 1.00
58_G 73_T 2.175 1.00
324_L 328_T 2.175 1.00
117_L 152_K 2.169 1.00
146_R 174_D 2.159 1.00
31_L 309_L 2.146 1.00
6_D 204_E 2.08 1.00
20_R 167_E 2.072 1.00
36_T 153_T 2.062 1.00
113_T 126_V 2.014 1.00
35_F 125_F 1.988 1.00
228_V 239_V 1.941 1.00
126_V 152_K 1.928 1.00
169_I 209_A 1.915 1.00
325_K 329_K 1.911 1.00
114_K 148_A 1.91 1.00
241_L 245_L 1.906 1.00
32_E 46_G 1.881 1.00
163_E 332_T 1.863 1.00
249_E 297_L 1.856 1.00
130_V 138_F 1.847 1.00
164_M 205_C 1.844 1.00
325_K 328_T 1.798 1.00
273_S 292_T 1.785 1.00
140_Q 143_A 1.774 1.00
74_A 125_F 1.761 1.00
100_M 125_F 1.757 1.00
109_D 141_F 1.757 1.00
49_I 305_A 1.756 1.00
159_V 164_M 1.755 1.00
159_V 205_C 1.755 1.00
167_E 170_L 1.705 1.00
35_F 155_C 1.687 1.00
103_T 113_T 1.686 1.00
113_T 145_A 1.674 1.00
321_A 326_E 1.663 1.00
162_G 208_A 1.658 1.00
145_A 154_I 1.656 0.99
178_V 216_I 1.643 0.99
49_I 245_L 1.64 0.99
142_V 156_A 1.627 0.99
87_F 90_N 1.58 0.99
165_C 169_I 1.554 0.99
232_F 328_T 1.53 0.99
143_A 147_E 1.517 0.99
87_F 91_S 1.515 0.99
160_V 196_Y 1.507 0.99
202_V 218_S 1.506 0.99
286_R 314_S 1.5 0.99
209_A 216_I 1.487 0.99
47_V 309_L 1.478 0.99
37_F 215_M 1.469 0.99
114_K 149_W 1.454 0.98
66_L 305_A 1.45 0.98
170_L 212_L 1.438 0.98
131_A 318_Y 1.435 0.98
206_A 216_I 1.432 0.98
36_T 175_I 1.428 0.98
241_L 244_M 1.428 0.98
166_E 211_G 1.421 0.98
34_Q 213_G 1.397 0.98
244_M 308_I 1.384 0.98
165_C 216_I 1.377 0.97
50_I 238_F 1.342 0.97
139_V 143_A 1.339 0.97
210_H 328_T 1.331 0.97
165_C 209_A 1.329 0.97
169_I 214_G 1.314 0.96
36_T 125_F 1.313 0.96
9_L 335_R 1.308 0.96
128_I 156_A 1.307 0.96
93_A 277_R 1.304 0.96
49_I 309_L 1.295 0.96
315_A 327_L 1.294 0.96
166_E 212_L 1.292 0.96
255_I 262_K 1.288 0.96
250_E 300_P 1.272 0.95
19_K 319_V 1.248 0.95
203_I 207_D 1.247 0.95
321_A 331_T 1.247 0.95
142_V 154_I 1.243 0.95
51_A 58_G 1.234 0.94
22_T 322_S 1.224 0.94
111_E 114_K 1.223 0.94
228_V 308_I 1.216 0.94
139_V 167_E 1.212 0.94
229_A 327_L 1.209 0.94
154_I 173_A 1.207 0.94
88_I 91_S 1.206 0.93
234_G 333_F 1.203 0.93
291_K 346_N 1.2 0.93
209_A 212_L 1.198 0.93
103_T 109_D 1.188 0.93
215_M 237_D 1.184 0.93
51_A 66_L 1.183 0.93
108_A 111_E 1.164 0.92
169_I 212_L 1.159 0.92
60_F 87_F 1.158 0.92
128_I 142_V 1.152 0.91
125_F 155_C 1.152 0.91
343_I 346_N 1.151 0.91
30_E 323_R 1.148 0.91
208_A 212_L 1.148 0.91
9_L 199_L 1.146 0.91
38_K 151_T 1.141 0.91
128_I 145_A 1.138 0.91
144_K 148_A 1.122 0.90
35_F 238_F 1.117 0.90
31_L 313_R 1.117 0.90
72_L 125_F 1.112 0.89
77_K 137_H 1.111 0.89
162_G 166_E 1.11 0.89
160_V 180_I 1.106 0.89
37_F 214_G 1.101 0.89
165_C 176_V 1.1 0.89
249_E 300_P 1.097 0.88
35_F 100_M 1.096 0.88
28_D 322_S 1.094 0.88
162_G 207_D 1.081 0.87
156_A 173_A 1.074 0.87
24_K 27_S 1.07 0.87
86_A 90_N 1.069 0.87
35_F 50_I 1.065 0.86
74_A 127_C 1.05 0.85
315_A 319_V 1.047 0.85
258_E 294_K 1.046 0.85
300_P 303_N 1.045 0.85
232_F 327_L 1.044 0.85
49_I 241_L 1.042 0.85
245_L 301_V 1.036 0.84
39_H 98_H 1.029 0.84
83_E 86_A 1.029 0.84
239_V 245_L 1.026 0.83
200_S 204_E 1.023 0.83
65_A 301_V 1.011 0.82
232_F 324_L 1.009 0.82
286_R 306_R 1.006 0.82
93_A 276_K 1.003 0.81
126_V 192_T 1.002 0.81
107_D 111_E 1 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4af0A10.97691000.434Contact Map0.747
4fxsA10.97691000.447Contact Map0.782
2cu0A20.96251000.454Contact Map0.742
3usbA20.97411000.46Contact Map0.754
1me8A10.97411000.473Contact Map0.765
1vrdA20.97691000.477Contact Map0.845
4avfA40.97691000.497Contact Map0.838
1jcnA20.97691000.503Contact Map0.74
1eepA20.97691000.52Contact Map0.773
1zfjA10.97691000.528Contact Map0.731
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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