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OPENSEQ.org
IMDH - Inosine-5'-monophosphate dehydrogenase
UniProt: P0ADG7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10421
Length: 488 (485)
Sequences: 1492
Seq/Len: 3.08
IMDH
Paralog alert: 0.10 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: GUAC IMDH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
69_F 221_G 6.011 1.00
37_T 272_Q 4.787 1.00
449_T 452_E 4.767 1.00
187_D 191_H 4.23 1.00
76_I 236_A 3.988 1.00
348_A 441_C 3.658 1.00
351_I 438_L 3.18 1.00
452_E 456_K 3.078 1.00
31_S 39_R 3.069 1.00
255_E 259_Q 2.975 1.00
356_S 454_R 2.969 1.00
285_R 289_E 2.914 1.00
235_D 239_A 2.758 1.00
33_Q 39_R 2.741 1.00
327_A 330_G 2.713 1.00
278_V 284_A 2.705 1.00
162_V 185_V 2.686 1.00
7_E 461_R 2.681 1.00
53_T 68_G 2.605 1.00
100_V 123_V 2.585 1.00
221_G 244_V 2.563 1.00
211_C 219_R 2.544 1.00
450_I 454_R 2.502 1.00
265_R 273_I 2.499 1.00
238_V 271_L 2.387 1.00
284_A 324_A 2.384 1.00
285_R 327_A 2.365 1.00
75_S 78_R 2.362 1.00
163_R 188_D 2.344 1.00
22_T 255_E 2.32 1.00
282_A 458_E 2.299 1.00
20_H 255_E 2.287 1.00
35_T 272_Q 2.272 1.00
107_R 111_E 2.263 1.00
69_F 244_V 2.254 1.00
448_G 452_E 2.243 1.00
245_L 271_L 2.213 1.00
234_V 264_T 2.181 1.00
265_R 293_S 2.179 1.00
147_Q 151_V 2.158 1.00
283_G 324_A 2.155 1.00
107_R 146_N 2.15 1.00
224_V 234_V 2.132 1.00
234_V 245_L 2.103 1.00
20_H 286_A 2.091 1.00
34_L 244_V 2.057 1.00
278_V 324_A 2.055 1.00
44_M 431_I 2.053 1.00
249_S 257_V 2.031 1.00
278_V 283_G 2.023 1.00
288_A 328_L 2.017 1.00
451_D 455_T 2.008 1.00
342_R 467_I 2.006 1.00
123_V 149_V 1.984 1.00
264_T 273_I 1.963 1.00
6_K 323_D 1.962 1.00
285_R 330_G 1.909 0.99
417_I 475_V 1.902 0.99
33_Q 332_G 1.9 0.99
31_S 41_N 1.884 0.99
30_L 435_M 1.884 0.99
82_E 85_R 1.853 0.99
351_I 454_R 1.845 0.99
447_C 452_E 1.84 0.99
347_I 358_V 1.839 0.99
35_T 294_A 1.831 0.99
284_A 288_A 1.825 0.99
451_D 454_R 1.796 0.99
360_V 364_L 1.794 0.99
259_Q 262_R 1.78 0.99
286_A 289_E 1.775 0.99
57_L 427_L 1.771 0.99
34_L 274_I 1.771 0.99
104_T 108_E 1.771 0.99
167_A 170_V 1.767 0.99
281_A 327_A 1.758 0.99
392_G 418_E 1.742 0.99
230_N 260_R 1.734 0.99
412_L 440_S 1.73 0.99
164_E 188_D 1.722 0.99
102_P 131_V 1.712 0.99
173_A 177_E 1.698 0.98
101_L 104_T 1.671 0.98
103_T 150_S 1.655 0.98
103_T 148_P 1.646 0.98
111_E 115_R 1.619 0.98
148_P 151_V 1.604 0.98
55_A 82_E 1.574 0.97
235_D 268_Y 1.562 0.97
44_M 364_L 1.561 0.97
284_A 335_V 1.559 0.97
34_L 221_G 1.55 0.97
61_L 431_I 1.549 0.97
235_D 267_K 1.545 0.97
35_T 244_V 1.541 0.97
289_E 331_T 1.53 0.96
441_C 453_L 1.527 0.96
285_R 331_T 1.502 0.96
186_V 190_F 1.5 0.96
250_S 444_L 1.482 0.95
348_A 453_L 1.482 0.95
328_L 335_V 1.474 0.95
142_V 147_Q 1.47 0.95
351_I 453_L 1.451 0.95
297_V 335_V 1.45 0.95
134_I 152_Y 1.446 0.95
360_V 363_M 1.444 0.95
262_R 266_A 1.438 0.94
363_M 434_Q 1.428 0.94
261_I 275_G 1.428 0.94
127_E 191_H 1.414 0.94
288_A 333_I 1.414 0.94
162_V 166_E 1.412 0.94
279_A 315_V 1.409 0.94
45_L 357_A 1.403 0.93
368_E 423_Y 1.393 0.93
156_K 190_F 1.391 0.93
129_E 191_H 1.386 0.93
124_V 128_N 1.384 0.93
69_F 246_L 1.376 0.93
247_I 275_G 1.373 0.92
42_I 435_M 1.365 0.92
44_M 435_M 1.355 0.92
36_K 334_P 1.352 0.92
57_L 364_L 1.351 0.92
273_I 292_C 1.337 0.91
105_T 108_E 1.329 0.91
288_A 331_T 1.329 0.91
261_I 273_I 1.327 0.91
447_C 457_A 1.326 0.91
244_V 274_I 1.325 0.91
163_R 166_E 1.321 0.90
100_V 149_V 1.308 0.90
108_E 111_E 1.307 0.90
284_A 328_L 1.295 0.89
37_T 214_E 1.289 0.89
247_I 261_I 1.283 0.89
329_E 454_R 1.28 0.89
328_L 331_T 1.274 0.88
412_L 432_H 1.27 0.88
100_V 109_V 1.255 0.87
9_L 461_R 1.254 0.87
325_V 335_V 1.241 0.86
83_V 222_A 1.236 0.86
67_I 244_V 1.231 0.86
265_R 292_C 1.23 0.86
229_G 232_E 1.228 0.86
34_L 45_L 1.223 0.85
44_M 360_V 1.22 0.85
143_T 173_A 1.219 0.85
224_V 230_N 1.219 0.85
364_L 427_L 1.215 0.85
19_A 456_K 1.214 0.85
24_L 256_G 1.207 0.84
22_T 448_G 1.203 0.84
232_E 235_D 1.197 0.84
45_L 274_I 1.19 0.83
29_D 449_T 1.189 0.83
109_V 113_T 1.189 0.83
78_R 82_E 1.189 0.83
100_V 104_T 1.187 0.83
34_L 357_A 1.186 0.83
37_T 270_D 1.184 0.83
247_I 264_T 1.183 0.83
29_D 39_R 1.183 0.83
322_A 326_E 1.18 0.82
57_L 61_L 1.178 0.82
258_L 262_R 1.172 0.82
19_A 445_T 1.17 0.82
242_V 271_L 1.167 0.81
9_L 318_I 1.158 0.81
351_I 450_I 1.155 0.80
275_G 292_C 1.154 0.80
70_I 83_V 1.152 0.80
83_V 242_V 1.149 0.80
230_N 234_V 1.148 0.80
327_A 331_T 1.142 0.79
262_R 289_E 1.133 0.79
170_V 173_A 1.132 0.79
166_E 170_V 1.132 0.79
98_Q 118_F 1.125 0.78
234_V 268_Y 1.124 0.78
321_V 337_A 1.118 0.77
72_K 256_G 1.111 0.77
284_A 295_V 1.111 0.77
108_E 149_V 1.109 0.77
353_A 459_F 1.105 0.76
61_L 364_L 1.101 0.76
453_L 457_A 1.1 0.76
39_R 219_R 1.095 0.75
281_A 285_R 1.093 0.75
334_P 356_S 1.088 0.75
272_Q 294_A 1.088 0.75
4_I 322_A 1.082 0.74
347_I 434_Q 1.079 0.74
462_I 467_I 1.079 0.74
125_T 191_H 1.073 0.73
164_E 193_I 1.07 0.73
419_G 475_V 1.069 0.73
21_S 251_H 1.069 0.73
121_Y 149_V 1.069 0.73
46_S 53_T 1.065 0.72
176_H 179_R 1.061 0.72
34_L 67_I 1.057 0.72
282_A 285_R 1.057 0.72
144_D 147_Q 1.055 0.71
351_I 457_A 1.053 0.71
374_I 381_S 1.051 0.71
448_G 456_K 1.05 0.71
326_E 330_G 1.048 0.71
245_L 311_T 1.045 0.70
319_T 323_D 1.042 0.70
118_F 121_Y 1.04 0.70
368_E 426_R 1.034 0.69
281_A 326_E 1.032 0.69
391_L 412_L 1.022 0.68
352_A 457_A 1.018 0.67
263_E 267_K 1.015 0.67
295_V 328_L 1.01 0.67
27_T 448_G 1.007 0.66
81_E 84_R 1.004 0.66
113_T 121_Y 1.004 0.66
472_V 475_V 1.004 0.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4fxsA111000.432Contact Map0.731
4af0A10.98161000.438Contact Map0.727
3usbA20.98981000.446Contact Map0.731
2cu0A20.97951000.45Contact Map0.716
1vrdA20.99591000.463Contact Map0.816
1me8A10.98771000.465Contact Map0.72
4avfA40.99591000.484Contact Map0.81
1jcnA20.98571000.492Contact Map0.678
1zfjA10.99391000.514Contact Map0.69
1eepA20.82381000.629Contact Map0.758
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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