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OPENSEQ.org
YFIN - Probable diguanylate cyclase YfiN
UniProt: P46139 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12880
Length: 408 (395)
Sequences: 784
Seq/Len: 1.98
YFIN
Paralog alert: 0.85 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ADRA YDAM YDEH YEAP YFIN YNEF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
318_G 321_H 3.295 1.00
299_H 396_Y 2.482 1.00
283_L 373_I 2.419 1.00
284_F 395_M 2.418 1.00
286_D 330_E 2.206 1.00
294_N 328_G 2.119 0.99
215_A 218_H 2.093 0.99
286_D 396_Y 2.09 0.99
379_I 382_A 2.08 0.99
291_K 295_D 2.074 0.99
80_L 92_A 2.031 0.99
330_E 392_D 1.97 0.99
294_N 303_D 1.956 0.99
286_D 299_H 1.925 0.99
260_R 392_D 1.861 0.98
392_D 396_Y 1.831 0.98
298_G 392_D 1.821 0.98
291_K 302_G 1.808 0.98
290_F 302_G 1.765 0.97
291_K 330_E 1.754 0.97
286_D 372_S 1.75 0.97
299_H 392_D 1.689 0.96
260_R 303_D 1.662 0.95
299_H 330_E 1.66 0.95
294_N 302_G 1.658 0.95
312_R 329_D 1.649 0.95
372_S 399_K 1.643 0.95
295_D 396_Y 1.579 0.93
322_K 334_V 1.572 0.93
290_F 299_H 1.548 0.93
372_S 396_Y 1.546 0.93
286_D 291_K 1.543 0.92
291_K 299_H 1.539 0.92
247_R 251_H 1.535 0.92
134_R 137_G 1.532 0.92
286_D 329_D 1.532 0.92
258_A 262_A 1.522 0.92
284_F 391_A 1.498 0.91
335_L 347_I 1.493 0.91
299_H 327_G 1.492 0.91
329_D 370_T 1.49 0.91
286_D 295_D 1.478 0.90
195_V 224_F 1.468 0.90
305_V 329_D 1.461 0.89
286_D 327_G 1.447 0.89
370_T 395_M 1.446 0.89
286_D 399_K 1.433 0.88
295_D 330_E 1.432 0.88
285_L 313_L 1.432 0.88
91_T 146_T 1.418 0.87
383_S 386_K 1.416 0.87
327_G 396_Y 1.409 0.87
302_G 329_D 1.405 0.87
254_L 303_D 1.398 0.86
290_F 295_D 1.395 0.86
281_A 344_V 1.391 0.86
330_E 396_Y 1.384 0.86
291_K 372_S 1.377 0.85
291_K 396_Y 1.372 0.85
260_R 294_N 1.365 0.85
328_G 396_Y 1.357 0.84
294_N 327_G 1.357 0.84
285_L 388_Q 1.346 0.84
374_G 391_A 1.344 0.83
96_D 100_N 1.339 0.83
309_I 355_F 1.338 0.83
327_G 372_S 1.338 0.83
18_L 25_S 1.337 0.83
312_R 395_M 1.336 0.83
24_T 27_F 1.327 0.82
318_G 333_M 1.326 0.82
290_F 294_N 1.326 0.82
275_D 318_G 1.319 0.82
67_A 76_A 1.314 0.81
396_Y 399_K 1.312 0.81
291_K 329_D 1.299 0.80
208_R 228_L 1.299 0.80
348_C 375_Y 1.286 0.79
374_G 394_N 1.284 0.79
281_A 377_M 1.283 0.79
187_E 373_I 1.283 0.79
13_T 20_N 1.28 0.79
141_G 225_N 1.274 0.79
303_D 328_G 1.266 0.78
67_A 103_A 1.266 0.78
294_N 392_D 1.259 0.77
271_M 324_Y 1.257 0.77
299_H 372_S 1.248 0.77
286_D 290_F 1.246 0.76
295_D 299_H 1.243 0.76
291_K 327_G 1.242 0.76
295_D 302_G 1.237 0.76
199_V 228_L 1.231 0.75
37_L 44_T 1.23 0.75
299_H 399_K 1.229 0.75
231_M 235_Q 1.219 0.74
301_T 304_R 1.217 0.74
299_H 302_G 1.21 0.73
94_V 178_T 1.204 0.73
22_S 33_I 1.204 0.73
288_D 327_G 1.195 0.72
290_F 329_D 1.195 0.72
333_M 347_I 1.192 0.72
214_I 218_H 1.189 0.72
254_L 294_N 1.178 0.71
251_H 329_D 1.178 0.71
340_S 343_E 1.178 0.71
303_D 392_D 1.177 0.70
295_D 329_D 1.177 0.70
317_G 323_A 1.173 0.70
95_R 101_I 1.169 0.70
297_W 305_V 1.169 0.70
330_E 372_S 1.168 0.70
205_F 231_M 1.167 0.70
284_F 384_A 1.166 0.69
24_T 28_I 1.162 0.69
302_G 328_G 1.161 0.69
260_R 298_G 1.157 0.69
313_L 317_G 1.153 0.68
303_D 325_R 1.152 0.68
291_K 294_N 1.151 0.68
28_I 31_M 1.147 0.68
254_L 262_A 1.142 0.67
290_F 327_G 1.14 0.67
288_D 302_G 1.136 0.67
72_D 75_A 1.127 0.66
92_A 102_L 1.125 0.65
349_S 353_Q 1.125 0.65
288_D 399_K 1.124 0.65
352_T 375_Y 1.124 0.65
15_K 19_R 1.123 0.65
284_F 355_F 1.122 0.65
284_F 329_D 1.119 0.65
294_N 299_H 1.117 0.65
196_V 223_D 1.116 0.64
79_T 92_A 1.116 0.64
290_F 399_K 1.115 0.64
317_G 333_M 1.11 0.64
182_H 192_I 1.109 0.64
225_N 228_L 1.108 0.64
198_D 204_N 1.105 0.63
286_D 392_D 1.103 0.63
283_L 383_S 1.1 0.63
291_K 328_G 1.093 0.62
286_D 302_G 1.092 0.62
329_D 395_M 1.088 0.62
302_G 327_G 1.084 0.61
26_I 30_M 1.083 0.61
288_D 374_G 1.082 0.61
120_I 126_P 1.082 0.61
249_A 329_D 1.081 0.61
94_V 181_L 1.079 0.61
288_D 330_E 1.078 0.61
304_R 307_I 1.076 0.60
295_D 399_K 1.075 0.60
14_F 21_I 1.072 0.60
392_D 395_M 1.067 0.59
345_Q 349_S 1.067 0.59
283_L 348_C 1.063 0.59
205_F 225_N 1.063 0.59
14_F 17_A 1.061 0.59
27_F 33_I 1.06 0.59
313_L 323_A 1.059 0.58
16_R 20_N 1.054 0.58
227_L 235_Q 1.052 0.58
295_D 327_G 1.052 0.58
262_A 266_G 1.049 0.57
209_V 225_N 1.048 0.57
306_L 328_G 1.047 0.57
263_F 350_A 1.045 0.57
296_T 396_Y 1.043 0.57
293_I 402_R 1.04 0.56
13_T 19_R 1.04 0.56
296_T 299_H 1.04 0.56
266_G 322_K 1.039 0.56
288_D 295_D 1.034 0.56
195_V 198_D 1.033 0.56
17_A 20_N 1.033 0.56
308_E 312_R 1.032 0.56
329_D 396_Y 1.031 0.55
271_M 280_S 1.028 0.55
324_Y 334_V 1.022 0.54
20_N 23_M 1.022 0.54
291_K 392_D 1.021 0.54
27_F 30_M 1.021 0.54
53_L 147_A 1.02 0.54
282_L 386_K 1.017 0.54
355_F 371_L 1.014 0.54
66_A 70_F 1.013 0.53
90_S 146_T 1.011 0.53
327_G 392_D 1.011 0.53
251_H 305_V 1.008 0.53
260_R 325_R 1.007 0.53
227_L 230_E 1.007 0.53
35_L 38_S 1.006 0.53
290_F 396_Y 1.002 0.52
161_A 276_A 1.002 0.52
307_I 323_A 1.001 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1w25A20.87011000.569Contact Map0.308
3pjxA10.42891000.579Contact Map0.278
3hvbA20.41671000.58Contact Map
3ezuA10.54171000.584Contact Map0.319
4h54A20.64711000.585Contact Map0.343
3ignA10.40441000.599Contact Map0.327
3i5cA20.45341000.602Contact Map0.334
3mtkA20.39221000.608Contact Map0.393
3tvkA10.39221000.619Contact Map0.316
3qyyA20.4021000.62Contact Map0.327
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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