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OPENSEQ.org
YEAP - Probable diguanylate cyclase YeaP
UniProt: P76245 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13502
Length: 341 (331)
Sequences: 1635
Seq/Len: 4.94
YEAP
Paralog alert: 0.37 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ADRA YDAM YDEH YEAP YFIN YNEF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
244_Q 247_E 4.477 1.00
209_A 298_L 3.147 1.00
195_L 198_L 3.068 1.00
207_M 302_E 2.88 1.00
214_D 297_S 2.861 1.00
215_N 329_Q 2.709 1.00
209_A 273_R 2.627 1.00
243_Q 249_I 2.595 1.00
163_L 167_N 2.472 1.00
304_D 307_T 2.471 1.00
201_H 244_Q 2.363 1.00
225_H 318_D 2.324 1.00
217_K 221_D 2.305 1.00
265_E 268_D 2.285 1.00
244_Q 275_R 2.244 1.00
188_I 250_G 2.226 1.00
318_D 322_Y 2.177 1.00
225_H 322_Y 2.136 1.00
220_N 228_G 2.117 1.00
324_E 328_K 2.095 1.00
309_D 312_S 2.057 1.00
274_E 277_Q 2.044 1.00
172_A 176_T 2.038 1.00
219_I 231_F 2.035 1.00
215_N 255_D 1.996 1.00
234_Q 238_R 1.903 1.00
221_D 318_D 1.895 1.00
221_D 225_H 1.879 1.00
183_P 187_A 1.872 1.00
188_I 258_L 1.858 1.00
191_N 194_T 1.845 1.00
75_S 78_K 1.836 1.00
217_K 322_Y 1.798 1.00
207_M 269_I 1.798 1.00
210_F 321_M 1.767 1.00
185_R 229_D 1.736 1.00
281_R 330_K 1.72 1.00
280_I 296_A 1.659 0.99
220_N 254_G 1.636 0.99
239_L 249_I 1.635 0.99
183_P 248_V 1.633 0.99
210_F 258_L 1.617 0.99
195_L 201_H 1.609 0.99
254_G 318_D 1.604 0.99
221_D 322_Y 1.583 0.99
217_K 254_G 1.572 0.99
254_G 325_K 1.571 0.99
255_D 321_M 1.571 0.99
320_A 324_E 1.54 0.99
220_N 325_K 1.518 0.99
238_R 283_E 1.51 0.99
217_K 225_H 1.507 0.99
255_D 330_K 1.496 0.98
295_G 330_K 1.485 0.98
234_Q 237_E 1.48 0.98
187_A 191_N 1.475 0.98
225_H 254_G 1.461 0.98
249_I 259_V 1.457 0.98
277_Q 281_R 1.448 0.98
77_C 109_F 1.439 0.98
315_H 319_I 1.436 0.98
255_D 329_Q 1.427 0.98
230_L 233_I 1.417 0.98
212_D 221_D 1.405 0.97
254_G 322_Y 1.39 0.97
217_K 256_E 1.387 0.97
216_F 232_L 1.384 0.97
225_H 256_E 1.382 0.97
225_H 253_G 1.372 0.97
169_A 172_A 1.372 0.97
204_H 263_N 1.37 0.97
321_M 324_E 1.345 0.96
256_E 322_Y 1.343 0.96
192_L 310_A 1.327 0.96
228_G 318_D 1.321 0.96
237_E 240_N 1.321 0.96
231_F 294_P 1.315 0.96
201_H 247_E 1.31 0.96
228_G 254_G 1.307 0.96
212_D 253_G 1.306 0.95
198_L 201_H 1.302 0.95
212_D 256_E 1.299 0.95
212_D 325_K 1.299 0.95
90_E 107_T 1.29 0.95
113_P 123_G 1.283 0.95
217_K 318_D 1.282 0.95
322_Y 325_K 1.281 0.95
253_G 322_Y 1.274 0.95
217_K 220_N 1.271 0.95
212_D 217_K 1.26 0.94
261_S 269_I 1.253 0.94
256_E 318_D 1.251 0.94
212_D 254_G 1.244 0.94
91_V 98_C 1.234 0.93
255_D 328_K 1.234 0.93
221_D 256_E 1.233 0.93
182_L 249_I 1.23 0.93
225_H 228_G 1.226 0.93
295_G 328_K 1.224 0.93
220_N 225_H 1.22 0.93
220_N 229_D 1.218 0.93
209_A 259_V 1.217 0.93
247_E 275_R 1.206 0.92
253_G 318_D 1.204 0.92
213_L 232_L 1.198 0.92
213_L 296_A 1.195 0.92
272_L 275_R 1.194 0.92
323_Q 327_H 1.193 0.92
221_D 254_G 1.185 0.91
256_E 325_K 1.178 0.91
217_K 228_G 1.176 0.91
211_I 235_V 1.176 0.91
216_F 297_S 1.174 0.91
18_S 21_S 1.167 0.91
34_T 127_A 1.166 0.91
226_N 315_H 1.161 0.90
108_T 135_W 1.156 0.90
216_F 255_D 1.156 0.90
228_G 325_K 1.156 0.90
307_T 316_A 1.154 0.90
117_P 155_Q 1.154 0.90
37_E 129_S 1.151 0.90
179_L 254_G 1.14 0.89
225_H 325_K 1.14 0.89
244_Q 272_L 1.137 0.89
207_M 300_I 1.129 0.89
220_N 256_E 1.128 0.89
255_D 295_G 1.128 0.89
212_D 220_N 1.127 0.88
23_V 27_L 1.125 0.88
211_I 259_V 1.125 0.88
179_L 185_R 1.122 0.88
191_N 248_V 1.121 0.88
206_I 313_A 1.117 0.88
43_K 122_Y 1.113 0.88
228_G 256_E 1.109 0.87
212_D 322_Y 1.105 0.87
179_L 229_D 1.1 0.87
217_K 325_K 1.1 0.87
233_I 237_E 1.098 0.87
212_D 225_H 1.096 0.87
78_K 81_I 1.095 0.86
212_D 255_D 1.095 0.86
110_L 143_L 1.09 0.86
216_F 220_N 1.088 0.86
225_H 229_D 1.087 0.86
252_L 314_L 1.08 0.85
220_N 253_G 1.08 0.85
212_D 228_G 1.078 0.85
220_N 255_D 1.078 0.85
188_I 260_V 1.076 0.85
214_D 329_Q 1.075 0.85
201_H 246_G 1.071 0.85
264_N 268_D 1.06 0.84
210_F 252_L 1.055 0.84
255_D 324_E 1.055 0.84
111_S 126_C 1.051 0.83
212_D 318_D 1.049 0.83
214_D 217_K 1.039 0.82
27_L 39_T 1.037 0.82
324_E 330_K 1.037 0.82
239_L 276_I 1.034 0.82
261_S 272_L 1.029 0.81
135_W 139_A 1.028 0.81
180_T 232_L 1.019 0.81
238_R 284_Y 1.015 0.80
114_I 151_A 1.007 0.79
252_L 258_L 1.002 0.79
114_I 123_G 1.001 0.79
228_G 251_R 1.001 0.79
220_N 318_D 1 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1w25A20.95891000.435Contact Map0.478
4eu0A10.83871000.452Contact Map0.47
3hvbA20.52491000.486Contact Map
4h54A20.84751000.496Contact Map0.527
3ezuA10.94721000.496Contact Map0.441
3pjxA10.53371000.501Contact Map0.381
3ignA10.51031000.508Contact Map0.535
3mtkA20.49271000.515Contact Map0.564
3i5cA20.57481000.519Contact Map0.499
3tvkA10.48971000.532Contact Map0.485
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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