May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YJHC - Uncharacterized oxidoreductase YjhC
UniProt: P39353 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12545
Length: 372 (360)
Sequences: 7395
Seq/Len: 20.54
YJHC
Paralog alert: 0.78 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: YCEM YCJS YDGJ YGJR YHHX YJHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
53_D 79_K 3.409 1.00
101_V 341_M 3.289 1.00
81_A 112_V 3.241 1.00
78_I 106_A 3.14 1.00
140_E 245_T 3.035 1.00
128_Y 131_K 3.026 1.00
121_N 179_D 2.961 1.00
3_N 27_K 2.954 1.00
101_V 345_A 2.804 1.00
130_R 134_K 2.793 1.00
78_I 82_K 2.704 1.00
191_T 218_E 2.651 1.00
51_S 54_A 2.643 1.00
215_M 350_A 2.64 1.00
74_K 102_D 2.607 1.00
82_K 106_A 2.596 1.00
105_K 109_E 2.596 1.00
108_K 338_E 2.575 1.00
131_K 135_E 2.575 1.00
190_E 220_P 2.53 1.00
78_I 102_D 2.503 1.00
5_G 55_L 2.495 1.00
352_L 356_Q 2.437 1.00
72_L 76_P 2.421 1.00
38_E 42_R 2.405 1.00
106_A 110_A 2.329 1.00
74_K 78_I 2.322 1.00
68_T 76_P 2.311 1.00
74_K 99_D 2.292 1.00
86_H 113_T 2.27 1.00
81_A 107_C 2.246 1.00
63_C 318_L 2.237 1.00
77_V 89_C 2.208 1.00
30_C 49_M 2.182 1.00
101_V 105_K 2.12 1.00
178_L 346_T 2.085 1.00
50_S 54_A 2.051 1.00
68_T 72_L 2.046 1.00
128_Y 132_L 2.026 1.00
61_V 85_K 1.975 1.00
96_S 99_D 1.97 1.00
141_I 242_I 1.938 1.00
82_K 110_A 1.931 1.00
138_I 244_G 1.926 1.00
320_N 324_G 1.919 1.00
82_K 109_E 1.912 1.00
20_M 65_I 1.909 1.00
129_A 249_I 1.87 1.00
25_N 323_C 1.868 1.00
75_E 79_K 1.847 1.00
3_N 62_D 1.844 1.00
4_Y 63_C 1.841 1.00
191_T 361_K 1.84 1.00
219_F 225_A 1.838 1.00
77_V 103_M 1.801 1.00
14_A 43_E 1.787 1.00
187_E 221_S 1.776 1.00
114_F 337_G 1.755 1.00
97_Y 348_D 1.747 1.00
132_L 137_V 1.746 1.00
86_H 112_V 1.7 1.00
104_V 341_M 1.699 1.00
5_G 61_V 1.69 1.00
317_F 321_I 1.688 1.00
94_A 103_M 1.677 1.00
74_K 103_M 1.666 1.00
193_T 359_K 1.659 1.00
39_N 43_E 1.625 1.00
95_L 99_D 1.623 1.00
349_A 360_V 1.615 1.00
64_V 80_A 1.601 1.00
55_L 61_V 1.583 1.00
117_G 314_E 1.575 1.00
49_M 58_S 1.542 1.00
190_E 218_E 1.541 1.00
30_C 55_L 1.517 1.00
142_L 245_T 1.504 1.00
49_M 55_L 1.502 1.00
66_V 77_V 1.497 1.00
105_K 108_K 1.497 1.00
26_A 319_H 1.492 1.00
138_I 247_G 1.464 1.00
52_L 56_V 1.46 1.00
23_H 316_L 1.456 1.00
138_I 141_I 1.447 1.00
52_L 79_K 1.442 1.00
81_A 87_V 1.43 1.00
37_G 41_A 1.429 1.00
145_H 241_I 1.426 1.00
187_E 220_P 1.422 1.00
113_T 325_A 1.418 1.00
104_V 337_G 1.416 1.00
56_V 80_A 1.406 0.99
81_A 110_A 1.397 0.99
3_N 29_T 1.395 0.99
57_S 83_N 1.394 0.99
66_V 76_P 1.382 0.99
106_A 109_E 1.382 0.99
102_D 105_K 1.381 0.99
342_S 345_A 1.378 0.99
102_D 106_A 1.378 0.99
352_L 355_S 1.363 0.99
191_T 359_K 1.36 0.99
80_A 87_V 1.346 0.99
99_D 102_D 1.339 0.99
54_A 57_S 1.336 0.99
60_L 85_K 1.327 0.99
178_L 347_A 1.323 0.99
130_R 183_H 1.311 0.99
2_I 63_C 1.309 0.99
100_C 341_M 1.308 0.99
9_V 31_V 1.296 0.99
79_K 82_K 1.293 0.99
132_L 135_E 1.28 0.99
189_P 219_F 1.278 0.99
32_Y 52_L 1.277 0.99
78_I 103_M 1.275 0.99
182_Q 219_F 1.274 0.99
336_N 339_A 1.271 0.99
182_Q 339_A 1.27 0.99
241_I 250_K 1.266 0.99
59_K 85_K 1.266 0.99
196_G 354_R 1.262 0.99
100_C 344_I 1.256 0.99
94_A 100_C 1.249 0.99
37_G 48_N 1.245 0.98
182_Q 342_S 1.245 0.98
58_S 61_V 1.244 0.98
97_Y 101_V 1.243 0.98
327_P 333_D 1.225 0.98
2_I 322_L 1.225 0.98
185_L 223_K 1.222 0.98
349_A 352_L 1.215 0.98
84_K 110_A 1.199 0.98
81_A 106_A 1.196 0.98
53_D 57_S 1.184 0.98
52_L 76_P 1.182 0.98
79_K 83_N 1.175 0.98
47_I 58_S 1.167 0.97
103_M 114_F 1.166 0.97
58_S 85_K 1.166 0.97
54_A 58_S 1.161 0.97
86_H 322_L 1.158 0.97
69_P 72_L 1.156 0.97
30_C 61_V 1.152 0.97
131_K 134_K 1.151 0.97
97_Y 345_A 1.149 0.97
181_V 225_A 1.149 0.97
348_D 352_L 1.146 0.97
17_A 28_I 1.132 0.97
89_C 103_M 1.127 0.97
32_Y 55_L 1.126 0.97
356_Q 360_V 1.12 0.96
349_A 353_S 1.12 0.96
66_V 80_A 1.119 0.96
320_N 325_A 1.114 0.96
349_A 362_I 1.113 0.96
4_Y 26_A 1.099 0.96
94_A 99_D 1.099 0.96
56_V 83_N 1.086 0.96
189_P 217_L 1.078 0.95
193_T 216_T 1.069 0.95
189_P 220_P 1.069 0.95
188_I 220_P 1.066 0.95
77_V 87_V 1.064 0.95
138_I 249_I 1.064 0.95
35_E 38_E 1.064 0.95
321_I 324_G 1.057 0.95
31_V 40_I 1.054 0.95
144_C 242_I 1.054 0.95
74_K 94_A 1.048 0.94
39_N 42_R 1.036 0.94
316_L 320_N 1.034 0.94
36_N 39_N 1.034 0.94
144_C 185_L 1.034 0.94
319_H 323_C 1.032 0.94
121_N 339_A 1.025 0.93
312_R 316_L 1.02 0.93
6_V 17_A 1.019 0.93
22_M 312_R 1.017 0.93
81_A 114_F 1.013 0.93
139_G 247_G 1.009 0.93
71_Y 166_Q 1.006 0.93
126_V 183_H 1.006 0.93
190_E 361_K 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1h6dA120.90321000.227Contact Map0.788
1zh8A20.84411000.24Contact Map0.766
3dtyA40.94891000.246Contact Map0.756
2nvwA20.98121000.247Contact Map0.794
3v5nA40.9221000.251Contact Map0.744
3db2A30.91671000.256Contact Map0.815
4gqaA40.93281000.263Contact Map0.78
3moiA10.94351000.263Contact Map0.696
4fb5A20.92471000.263Contact Map0.789
4koaA10.8791000.264Contact Map0.718
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.736 seconds.