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OPENSEQ.org
YDGJ - Uncharacterized oxidoreductase YdgJ
UniProt: P77376 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13931
Length: 346 (343)
Sequences: 8945
Seq/Len: 26.08
YDGJ
Paralog alert: 0.82 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: YCEM YCJS YDGJ YGJR YHHX YJHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
57_K 83_A 3.384 1.00
82_K 110_L 3.133 1.00
132_T 135_G 3.041 1.00
85_L 116_R 2.976 1.00
105_R 324_I 2.954 1.00
6_R 31_E 2.932 1.00
144_E 243_S 2.919 1.00
194_S 217_S 2.746 1.00
86_E 110_L 2.687 1.00
125_R 183_D 2.672 1.00
82_K 86_E 2.666 1.00
78_F 106_E 2.615 1.00
134_K 138_A 2.605 1.00
193_V 219_P 2.587 1.00
105_R 328_E 2.552 1.00
112_K 321_S 2.529 1.00
214_A 333_G 2.519 1.00
135_G 139_E 2.472 1.00
55_E 58_H 2.457 1.00
109_A 113_S 2.398 1.00
82_K 106_E 2.381 1.00
72_T 80_L 2.342 1.00
78_F 103_Q 2.331 1.00
76_T 80_L 2.308 1.00
110_L 114_L 2.291 1.00
78_F 82_K 2.277 1.00
67_L 306_I 2.251 1.00
81_A 93_V 2.215 1.00
34_V 53_V 2.214 1.00
8_G 59_L 2.204 1.00
90_H 117_V 2.202 1.00
335_E 339_H 2.194 1.00
308_D 312_G 2.182 1.00
132_T 136_L 2.115 1.00
85_L 111_A 2.047 1.00
105_R 109_A 2.023 1.00
51_T 62_D 2.019 1.00
54_S 58_H 1.978 1.00
29_G 311_N 1.964 1.00
4_N 31_E 1.944 1.00
86_E 114_L 1.92 1.00
65_I 89_K 1.907 1.00
142_L 242_G 1.903 1.00
72_T 76_T 1.902 1.00
182_L 329_L 1.88 1.00
145_V 240_V 1.852 1.00
81_A 107_L 1.852 1.00
100_T 103_Q 1.822 1.00
117_V 313_D 1.809 1.00
86_E 113_S 1.8 1.00
133_L 247_Y 1.797 1.00
39_D 42_K 1.794 1.00
79_P 83_A 1.79 1.00
136_L 141_V 1.773 1.00
17_K 46_D 1.751 1.00
101_L 331_E 1.732 1.00
90_H 116_R 1.732 1.00
194_S 344_C 1.726 1.00
118_L 320_A 1.718 1.00
98_T 107_L 1.699 1.00
78_F 107_L 1.689 1.00
7_V 67_L 1.686 1.00
68_I 84_A 1.683 1.00
218_Y 223_V 1.678 1.00
30_Q 307_R 1.639 1.00
24_I 69_V 1.638 1.00
6_R 66_D 1.601 1.00
59_L 65_I 1.586 1.00
8_G 65_I 1.583 1.00
146_A 243_S 1.579 1.00
99_V 103_Q 1.575 1.00
53_V 62_D 1.554 1.00
27_T 304_A 1.536 1.00
108_D 324_I 1.527 1.00
305_A 309_A 1.52 1.00
199_L 337_A 1.506 1.00
60_F 84_A 1.501 1.00
61_N 87_A 1.494 1.00
149_E 239_I 1.469 1.00
108_D 320_A 1.469 1.00
192_P 218_Y 1.468 1.00
196_T 342_T 1.467 1.00
58_H 61_N 1.451 1.00
56_P 83_A 1.446 1.00
193_V 217_S 1.443 1.00
110_L 113_S 1.437 1.00
6_R 33_A 1.436 1.00
191_L 219_P 1.432 1.00
34_V 59_L 1.424 1.00
332_L 343_L 1.42 1.00
53_V 59_L 1.417 1.00
142_L 245_G 1.416 1.00
85_L 114_L 1.414 1.00
12_Y 35_I 1.384 0.99
134_K 187_T 1.383 0.99
64_N 89_K 1.377 0.99
109_A 112_K 1.374 0.99
182_L 330_I 1.372 0.99
325_Q 328_E 1.37 0.99
70_I 81_A 1.369 0.99
106_E 109_A 1.365 0.99
194_S 342_T 1.364 0.99
85_L 91_V 1.362 0.99
83_A 86_E 1.346 0.99
186_I 322_Q 1.345 0.99
56_P 60_F 1.342 0.99
142_L 145_V 1.34 0.99
98_T 104_A 1.334 0.99
104_A 324_I 1.333 0.99
121_F 302_Y 1.328 0.99
90_H 310_L 1.324 0.99
36_S 56_P 1.321 0.99
57_K 61_N 1.314 0.99
84_A 91_V 1.303 0.99
101_L 328_E 1.3 0.99
106_E 110_L 1.29 0.99
239_I 248_V 1.285 0.99
63_P 89_K 1.276 0.99
88_G 114_L 1.274 0.99
40_E 54_S 1.267 0.99
136_L 139_E 1.262 0.99
5_I 67_L 1.259 0.99
191_L 325_Q 1.254 0.99
332_L 336_S 1.254 0.99
186_I 191_L 1.247 0.99
308_D 314_G 1.244 0.98
104_A 327_M 1.235 0.98
186_I 325_Q 1.233 0.98
103_Q 106_E 1.232 0.98
82_K 107_L 1.203 0.98
101_L 105_R 1.202 0.98
90_H 313_D 1.196 0.98
319_P 322_Q 1.189 0.98
70_I 80_L 1.188 0.98
5_I 310_L 1.188 0.98
135_G 138_A 1.184 0.98
85_L 110_L 1.18 0.98
332_L 335_E 1.18 0.98
237_R 248_V 1.173 0.98
62_D 65_I 1.166 0.97
107_L 118_L 1.165 0.97
198_D 217_S 1.163 0.97
36_S 59_L 1.162 0.97
83_A 87_A 1.16 0.97
335_E 338_K 1.15 0.97
307_R 311_N 1.148 0.97
56_P 80_L 1.145 0.97
196_T 215_I 1.143 0.97
186_I 218_Y 1.135 0.97
58_H 62_D 1.133 0.97
331_E 335_E 1.132 0.97
125_R 322_Q 1.112 0.96
60_F 87_A 1.111 0.96
7_V 30_Q 1.104 0.96
62_D 89_K 1.098 0.96
73_P 76_T 1.094 0.96
304_A 308_D 1.089 0.96
185_A 223_V 1.085 0.96
108_D 321_S 1.081 0.95
34_V 65_I 1.077 0.95
126_W 305_A 1.065 0.95
192_P 216_L 1.057 0.95
339_H 343_L 1.05 0.94
98_T 103_Q 1.048 0.94
35_I 43_V 1.043 0.94
81_A 85_L 1.041 0.94
97_F 104_A 1.03 0.94
93_V 118_L 1.026 0.94
305_A 317_P 1.021 0.93
192_P 219_P 1.018 0.93
197_V 333_G 1.018 0.93
8_G 36_S 1.016 0.93
93_V 107_L 1.013 0.93
309_A 316_N 1.004 0.93
142_L 247_Y 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kuxA10.99711000.16Contact Map0.757
3fhlA411000.163Contact Map0.774
3gdoA211000.166Contact Map0.795
3e82A40.99131000.169Contact Map0.791
1h6dA120.95091000.185Contact Map0.797
3dtyA40.98841000.187Contact Map0.766
3v5nA40.98551000.195Contact Map0.754
1zh8A20.90461000.196Contact Map0.784
3i23A20.98271000.2Contact Map0.742
3f4lA60.98271000.2Contact Map0.741
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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