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OPENSEQ.org
UXUB - D-mannonate oxidoreductase
UniProt: P39160 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG20248
Length: 486 (478)
Sequences: 1068
Seq/Len: 2.23
UXUB
Paralog alert: 0.63 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: MTLD UXAB UXUB YDFI YEIQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
43_H 92_K 3.488 1.00
58_V 111_I 2.846 1.00
42_T 273_W 2.818 1.00
320_N 480_R 2.707 1.00
234_P 237_L 2.511 1.00
328_F 352_T 2.506 1.00
109_E 171_L 2.498 1.00
262_I 278_A 2.496 1.00
143_L 205_A 2.481 1.00
113_N 175_K 2.426 1.00
473_Q 482_C 2.418 1.00
44_H 92_K 2.313 1.00
311_Y 320_N 2.208 1.00
34_H 38_Q 2.196 1.00
23_S 56_C 2.161 1.00
25_I 42_T 2.152 1.00
238_Q 242_D 2.128 1.00
117_R 120_T 2.128 1.00
167_E 171_L 2.125 1.00
241_A 247_Y 2.083 0.99
173_R 209_Q 2.08 0.99
26_V 120_T 2.075 0.99
116_A 171_L 2.043 0.99
273_W 278_A 2.025 0.99
121_A 270_R 2.016 0.99
99_E 114_A 2.004 0.99
329_A 333_Q 1.991 0.99
365_H 369_Q 1.981 0.99
193_H 222_C 1.95 0.99
317_T 323_Y 1.948 0.99
60_L 164_Y 1.899 0.99
56_C 114_A 1.898 0.99
403_V 463_F 1.874 0.99
304_Y 374_G 1.858 0.98
107_G 110_G 1.803 0.98
56_C 99_E 1.797 0.98
305_L 401_L 1.783 0.98
481_E 484_A 1.769 0.98
171_L 175_K 1.761 0.98
115_M 168_A 1.754 0.98
160_S 163_G 1.748 0.98
307_Y 420_I 1.742 0.97
182_V 195_A 1.739 0.97
16_W 43_H 1.72 0.97
81_V 94_I 1.693 0.97
212_A 216_E 1.689 0.97
219_T 265_N 1.688 0.97
147_L 159_K 1.654 0.96
301_F 402_G 1.649 0.96
294_M 336_A 1.636 0.96
219_T 267_V 1.615 0.95
203_A 214_I 1.606 0.95
332_M 351_A 1.606 0.95
272_D 275_K 1.605 0.95
73_K 77_L 1.604 0.95
17_D 20_R 1.603 0.95
386_V 403_V 1.599 0.95
336_A 351_A 1.599 0.95
78_L 93_I 1.596 0.95
43_H 47_E 1.574 0.95
294_M 331_M 1.573 0.95
389_H 394_G 1.571 0.95
125_L 161_A 1.568 0.94
21_L 54_G 1.565 0.94
134_A 198_A 1.559 0.94
401_L 474_L 1.554 0.94
386_V 463_F 1.548 0.94
127_V 161_A 1.547 0.94
208_P 212_A 1.546 0.94
23_S 99_E 1.544 0.94
196_K 200_L 1.542 0.94
294_M 351_A 1.54 0.94
466_A 470_A 1.524 0.93
305_L 405_G 1.507 0.93
474_L 482_C 1.497 0.92
109_E 113_N 1.489 0.92
26_V 58_V 1.486 0.92
130_K 376_Q 1.484 0.92
473_Q 485_A 1.477 0.92
54_G 98_K 1.47 0.92
170_R 174_E 1.443 0.91
56_C 120_T 1.442 0.91
324_R 359_S 1.437 0.90
199_V 220_F 1.437 0.90
180_F 218_V 1.425 0.90
306_G 317_T 1.424 0.90
461_A 465_G 1.422 0.90
183_M 262_I 1.42 0.90
40_L 81_V 1.418 0.90
99_E 110_G 1.417 0.89
458_P 464_V 1.412 0.89
212_A 215_E 1.404 0.89
57_E 97_M 1.4 0.89
305_L 474_L 1.39 0.88
168_A 180_F 1.378 0.88
190_E 285_V 1.367 0.87
286_P 339_L 1.364 0.87
302_L 323_Y 1.364 0.87
270_R 274_D 1.349 0.86
375_S 452_I 1.346 0.86
25_I 55_I 1.346 0.86
83_E 254_C 1.343 0.86
209_Q 212_A 1.339 0.86
112_L 167_E 1.326 0.85
123_V 180_F 1.322 0.85
314_I 367_T 1.317 0.84
303_A 371_A 1.313 0.84
144_N 149_K 1.312 0.84
22_E 119_Q 1.303 0.83
298_S 327_A 1.299 0.83
365_H 381_R 1.297 0.83
112_L 171_L 1.294 0.83
234_P 238_Q 1.293 0.83
170_R 207_D 1.286 0.82
281_V 286_P 1.279 0.82
289_M 340_S 1.279 0.82
400_A 467_V 1.274 0.82
214_I 220_F 1.269 0.81
33_F 185_C 1.268 0.81
301_F 326_A 1.266 0.81
387_R 455_D 1.263 0.81
300_S 377_K 1.263 0.81
448_G 458_P 1.262 0.81
110_G 113_N 1.261 0.81
294_M 354_L 1.26 0.81
170_R 206_R 1.251 0.80
50_D 275_K 1.25 0.80
23_S 120_T 1.25 0.80
133_C 160_S 1.25 0.80
123_V 165_I 1.249 0.80
450_S 459_Q 1.245 0.79
322_A 484_A 1.236 0.79
41_Y 258_R 1.235 0.79
204_Q 211_A 1.232 0.78
179_A 218_V 1.22 0.77
173_R 207_D 1.219 0.77
55_I 96_S 1.218 0.77
314_I 370_I 1.216 0.77
347_L 351_A 1.214 0.77
165_I 199_V 1.207 0.76
28_L 115_M 1.205 0.76
229_V 363_L 1.205 0.76
301_F 330_L 1.198 0.76
278_A 314_I 1.193 0.75
407_M 446_L 1.188 0.75
78_L 95_G 1.188 0.75
10_P 13_R 1.188 0.75
150_H 154_N 1.187 0.75
318_V 324_R 1.185 0.75
478_G 482_C 1.184 0.74
24_R 121_A 1.177 0.74
133_C 145_N 1.172 0.73
190_E 193_H 1.172 0.73
147_L 160_S 1.167 0.73
84_K 236_T 1.161 0.72
23_S 98_K 1.161 0.72
363_L 382_L 1.16 0.72
72_L 77_L 1.156 0.72
400_A 463_F 1.155 0.72
378_L 402_G 1.154 0.72
130_K 381_R 1.154 0.72
408_R 471_Y 1.153 0.72
80_T 93_I 1.152 0.72
232_A 252_I 1.149 0.71
173_R 210_L 1.142 0.71
166_V 199_V 1.14 0.70
429_E 451_G 1.137 0.70
385_P 399_L 1.137 0.70
30_C 57_E 1.133 0.70
116_A 168_A 1.128 0.69
307_Y 368_W 1.125 0.69
298_S 331_M 1.125 0.69
180_F 203_A 1.124 0.69
477_R 485_A 1.123 0.69
365_H 370_I 1.12 0.68
77_L 100_A 1.119 0.68
375_S 406_W 1.116 0.68
232_A 251_A 1.11 0.67
328_F 332_M 1.107 0.67
274_D 280_F 1.107 0.67
200_L 211_A 1.106 0.67
75_Q 78_L 1.105 0.67
312_E 316_D 1.101 0.67
122_I 270_R 1.099 0.66
135_D 138_S 1.098 0.66
181_T 221_P 1.098 0.66
411_Q 434_N 1.089 0.65
415_E 420_I 1.082 0.65
94_I 97_M 1.081 0.64
130_K 373_D 1.081 0.64
444_K 448_G 1.08 0.64
329_A 398_H 1.079 0.64
152_L 202_L 1.078 0.64
331_M 355_I 1.075 0.64
322_A 480_R 1.073 0.64
163_G 202_L 1.072 0.64
166_V 203_A 1.071 0.63
81_V 363_L 1.068 0.63
26_V 123_V 1.067 0.63
134_A 194_V 1.066 0.63
165_I 195_A 1.064 0.63
314_I 327_A 1.063 0.63
82_A 91_L 1.059 0.62
101_L 111_I 1.057 0.62
166_V 202_L 1.053 0.61
25_I 122_I 1.051 0.61
33_F 38_Q 1.051 0.61
232_A 237_L 1.05 0.61
140_Q 201_G 1.049 0.61
124_S 223_T 1.048 0.61
16_W 95_G 1.046 0.61
431_Q 435_A 1.046 0.61
314_I 358_F 1.045 0.61
30_C 97_M 1.045 0.61
39_A 55_I 1.045 0.61
125_L 184_S 1.044 0.60
315_A 319_T 1.043 0.60
169_L 213_W 1.041 0.60
28_L 161_A 1.041 0.60
74_K 432_K 1.032 0.59
335_Q 399_L 1.032 0.59
424_D 453_F 1.031 0.59
86_A 361_P 1.031 0.59
334_E 370_I 1.03 0.59
166_V 214_I 1.029 0.59
108_C 164_Y 1.028 0.59
294_M 335_Q 1.026 0.59
142_D 252_I 1.026 0.59
113_N 116_A 1.022 0.58
309_G 323_Y 1.021 0.58
293_R 388_L 1.02 0.58
42_T 55_I 1.018 0.58
209_Q 216_E 1.015 0.57
311_Y 409_Y 1.011 0.57
200_L 214_I 1.009 0.57
375_S 424_D 1.008 0.56
162_I 365_H 1.007 0.56
84_K 227_R 1.004 0.56
178_K 268_N 1.004 0.56
34_H 37_H 1.003 0.56
307_Y 409_Y 1.002 0.56
479_A 482_C 1.002 0.56
368_W 409_Y 1.001 0.56
366_R 369_Q 1 0.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4im7A10.99181000.117Contact Map0.73
1lj8A10.99181000.117Contact Map0.777
3h2zA10.77161000.403Contact Map0.589
1z9bA10.17916.40.983Contact Map0.046
2llwA10.13996.70.986Contact Map0.331
1rijA10.04736.10.986Contact Map0
3k7dA20.318960.986Contact Map0.166
4h44G10.07415.70.986Contact Map0
3rstA80.35395.60.986Contact Map0.313
1fqiA10.29425.50.986Contact Map0.38
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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