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OPENSEQ.org
UXAB - Altronate oxidoreductase
UniProt: P0A6L7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11065
Length: 483 (479)
Sequences: 1070
Seq/Len: 2.23
UXAB
Paralog alert: 0.63 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: MTLD UXAB UXUB YDFI YEIQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
36_D 87_R 3.766 1.00
310_D 476_R 2.722 1.00
35_I 261_L 2.683 1.00
318_E 341_S 2.659 1.00
249_I 268_V 2.635 1.00
103_D 152_E 2.552 1.00
107_K 160_A 2.486 1.00
94_R 108_L 2.439 1.00
221_R 224_V 2.439 1.00
469_A 478_A 2.423 1.00
37_L 87_R 2.342 1.00
27_L 31_V 2.264 1.00
301_L 310_D 2.261 1.00
228_E 234_H 2.216 1.00
225_A 229_E 2.206 1.00
111_N 114_M 2.199 1.00
148_R 152_E 2.179 1.00
18_I 35_I 2.168 1.00
19_I 114_M 2.118 1.00
154_F 196_A 2.053 0.99
354_H 358_S 2.031 0.99
110_H 152_E 2.027 0.99
307_A 313_I 1.994 0.99
261_L 268_V 1.968 0.99
319_K 323_E 1.932 0.99
51_V 105_F 1.93 0.99
115_R 258_E 1.928 0.99
294_P 363_G 1.927 0.99
178_D 209_S 1.926 0.99
68_L 88_L 1.893 0.99
295_V 391_F 1.874 0.99
469_A 481_P 1.828 0.98
199_Q 203_Q 1.822 0.98
141_S 144_A 1.816 0.98
393_L 459_L 1.805 0.98
109_A 149_L 1.783 0.98
477_E 480_R 1.78 0.98
322_Y 340_A 1.767 0.98
167_I 180_L 1.761 0.98
49_V 108_L 1.761 0.98
71_T 89_I 1.761 0.98
101_E 104_E 1.746 0.97
284_I 326_I 1.74 0.97
260_R 263_K 1.739 0.97
326_I 340_A 1.727 0.97
297_F 409_Y 1.709 0.97
16_E 94_R 1.697 0.97
284_I 321_I 1.655 0.96
284_I 340_A 1.637 0.96
291_A 392_A 1.632 0.96
128_Y 183_L 1.627 0.96
63_S 67_G 1.625 0.96
49_V 94_R 1.616 0.96
375_L 393_L 1.599 0.95
36_D 40_E 1.589 0.95
16_E 49_V 1.576 0.95
470_I 478_A 1.57 0.95
195_E 199_Q 1.562 0.94
181_R 185_L 1.556 0.94
103_D 107_K 1.556 0.94
124_A 365_T 1.551 0.94
121_T 142_Y 1.547 0.94
375_L 459_L 1.521 0.93
199_Q 202_D 1.513 0.93
119_S 142_Y 1.499 0.93
314_C 348_R 1.488 0.92
206_S 252_P 1.487 0.92
295_V 395_A 1.487 0.92
184_V 207_F 1.477 0.92
151_F 155_S 1.472 0.92
462_Q 466_D 1.459 0.91
50_V 92_V 1.454 0.91
292_L 313_I 1.451 0.91
168_I 249_I 1.451 0.91
47_G 93_N 1.449 0.91
94_R 104_E 1.446 0.91
33_W 71_T 1.444 0.91
15_P 113_E 1.442 0.91
165_W 205_N 1.44 0.90
391_F 470_I 1.44 0.90
446_K 455_Q 1.433 0.90
18_I 48_V 1.428 0.90
304_V 356_L 1.408 0.89
188_A 201_L 1.402 0.89
258_E 262_D 1.401 0.89
354_H 370_R 1.4 0.89
117_V 165_W 1.4 0.89
155_S 160_A 1.4 0.89
175_Y 275_K 1.394 0.88
454_T 460_V 1.391 0.88
16_E 93_N 1.381 0.88
296_A 307_A 1.376 0.88
376_L 452_D 1.367 0.87
290_T 366_K 1.366 0.87
106_L 148_R 1.366 0.87
397_I 442_V 1.364 0.87
34_Q 245_Y 1.361 0.87
16_E 114_M 1.359 0.87
276_P 329_L 1.351 0.86
21_F 109_A 1.35 0.86
295_V 470_I 1.343 0.86
457_P 461_E 1.34 0.86
288_A 317_V 1.336 0.85
284_I 343_V 1.335 0.85
127_S 141_S 1.321 0.85
26_F 170_C 1.307 0.84
293_V 360_A 1.307 0.84
73_I 241_A 1.306 0.84
291_A 320_A 1.306 0.84
48_V 91_S 1.303 0.83
196_A 199_Q 1.3 0.83
262_D 270_I 1.295 0.83
216_V 352_I 1.294 0.83
149_L 165_W 1.293 0.83
152_E 160_A 1.292 0.83
283_A 377_A 1.29 0.83
279_E 330_D 1.279 0.82
312_E 480_R 1.279 0.82
117_V 146_L 1.276 0.82
381_A 384_T 1.271 0.81
474_G 478_A 1.268 0.81
201_L 207_F 1.268 0.81
291_A 316_F 1.264 0.81
154_F 194_P 1.263 0.81
444_A 454_T 1.256 0.80
106_L 152_E 1.256 0.80
336_L 340_A 1.253 0.80
378_G 384_T 1.251 0.80
164_G 205_N 1.25 0.80
219_Y 238_L 1.248 0.80
68_L 90_R 1.247 0.80
146_L 184_V 1.245 0.79
70_T 88_L 1.244 0.79
390_T 463_V 1.242 0.79
352_I 371_I 1.241 0.79
104_E 107_K 1.24 0.79
304_V 359_I 1.231 0.78
364_M 448_H 1.231 0.78
124_A 370_R 1.227 0.78
271_V 276_P 1.225 0.78
151_F 194_P 1.211 0.77
189_Q 198_I 1.209 0.77
318_E 322_Y 1.204 0.76
268_V 304_V 1.203 0.76
23_E 50_V 1.193 0.75
374_Q 389_L 1.193 0.75
354_H 359_I 1.192 0.75
304_V 317_V 1.177 0.74
401_R 425_W 1.175 0.74
154_F 197_F 1.172 0.73
221_R 225_A 1.168 0.73
320_A 389_L 1.161 0.72
23_E 92_V 1.159 0.72
33_W 87_R 1.158 0.72
297_F 357_L 1.15 0.71
325_I 389_L 1.147 0.71
185_L 198_I 1.142 0.71
288_A 321_I 1.14 0.70
65_Q 68_L 1.14 0.70
319_K 388_R 1.139 0.70
146_L 180_L 1.134 0.70
147_T 188_A 1.133 0.70
390_T 459_L 1.133 0.70
147_T 184_V 1.13 0.69
440_A 460_V 1.129 0.69
67_G 95_E 1.126 0.69
367_F 392_A 1.122 0.69
175_Y 178_D 1.121 0.69
52_R 55_E 1.12 0.68
174_D 287_G 1.119 0.68
398_A 467_L 1.117 0.68
312_E 476_R 1.115 0.68
62_L 67_G 1.115 0.68
102_Y 145_K 1.114 0.68
308_M 314_C 1.114 0.68
420_R 447_D 1.111 0.68
364_M 396_L 1.111 0.68
71_T 352_I 1.109 0.67
475_M 478_A 1.108 0.67
150_L 200_W 1.106 0.67
17_R 115_R 1.106 0.67
308_M 344_T 1.104 0.67
35_I 48_V 1.103 0.67
128_Y 179_A 1.103 0.67
21_F 142_Y 1.103 0.67
32_D 48_V 1.101 0.67
124_A 362_N 1.095 0.66
321_I 344_T 1.093 0.66
118_F 210_T 1.091 0.66
110_H 149_L 1.089 0.65
74_R 223_E 1.089 0.65
144_A 187_Y 1.089 0.65
52_R 97_S 1.086 0.65
27_L 30_F 1.081 0.64
299_A 313_I 1.079 0.64
419_E 423_Q 1.078 0.64
220_P 223_E 1.077 0.64
304_V 347_F 1.075 0.64
65_Q 235_D 1.075 0.64
446_K 452_D 1.075 0.64
54_I 57_S 1.075 0.64
301_L 399_F 1.072 0.64
219_Y 224_V 1.069 0.63
18_I 116_F 1.068 0.63
214_R 241_A 1.065 0.63
365_T 370_R 1.065 0.63
473_K 481_P 1.061 0.62
304_V 307_A 1.056 0.62
74_R 214_R 1.056 0.62
288_A 343_V 1.05 0.61
166_I 208_C 1.048 0.61
143_P 354_H 1.046 0.61
219_Y 239_D 1.045 0.61
147_T 187_Y 1.041 0.60
379_Q 386_P 1.039 0.60
51_V 54_I 1.038 0.60
305_G 309_N 1.037 0.60
302_D 306_E 1.036 0.60
196_A 203_Q 1.034 0.59
315_A 319_K 1.034 0.59
297_F 399_F 1.032 0.59
324_E 388_R 1.026 0.59
69_Y 214_R 1.025 0.58
45_N 210_T 1.023 0.58
53_P 145_K 1.021 0.58
423_Q 426_S 1.02 0.58
195_E 383_G 1.019 0.58
355_Q 358_S 1.017 0.57
19_I 117_V 1.017 0.57
397_I 463_V 1.014 0.57
196_A 341_S 1.01 0.57
119_S 169_P 1.008 0.56
165_W 188_A 1.007 0.56
422_Q 426_S 1.007 0.56
89_I 92_V 1.006 0.56
143_P 370_R 1.005 0.56
344_T 348_R 1.004 0.56
284_I 325_I 1.003 0.56
33_W 89_I 1.003 0.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4im7A10.95651000.16Contact Map0.724
1lj8A10.95031000.165Contact Map0.755
3h2zA10.77641000.392Contact Map0.582
1z9bA10.1656220.982Contact Map0.034
4kjzA40.182213.30.983Contact Map0.05
2llwA10.140812.10.984Contact Map0.373
3k7dA20.310690.985Contact Map0.266
1rijA10.04768.40.985Contact Map0
3bkhA10.49485.90.986Contact Map0.261
3rstA80.34585.70.986Contact Map0.269
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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