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NORW - Nitric oxide reductase FlRd-NAD(+) reductase
UniProt: P37596 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12450
Length: 377 (366)
Sequences: 13247
Seq/Len: 36.19
NORW
Paralog alert: 0.87 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: DHNA DLDH GSHR HCAD NORW STHA TRXB YKGC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
145_L 228_V 4.413 1.00
258_D 262_Q 4.128 1.00
89_R 267_D 3.681 1.00
168_T 201_L 3.497 1.00
143_R 166_A 3.47 1.00
166_A 199_H 3.422 1.00
190_Q 194_T 3.414 1.00
250_T 256_C 2.915 1.00
17_L 104_V 2.905 1.00
6_V 91_V 2.877 1.00
90_V 97_Q 2.736 1.00
208_G 219_T 2.732 1.00
4_G 29_P 2.674 1.00
85_D 88_A 2.638 1.00
100_Y 103_L 2.508 1.00
86_A 265_N 2.497 1.00
145_L 170_I 2.494 1.00
110_S 242_A 2.487 1.00
112_F 238_R 2.486 1.00
145_L 218_A 2.47 1.00
117_P 208_G 2.466 1.00
13_A 271_L 2.39 1.00
35_A 80_W 2.336 1.00
3_N 74_H 2.33 1.00
92_K 97_Q 2.307 1.00
174_A 203_K 2.295 1.00
172_N 205_Q 2.274 1.00
90_V 99_Q 2.264 1.00
102_K 267_D 2.263 1.00
6_V 98_W 2.26 1.00
143_R 229_D 2.251 1.00
210_E 219_T 2.238 1.00
4_G 101_D 2.212 1.00
5_I 21_I 2.195 1.00
217_Q 225_N 2.186 1.00
110_S 240_E 2.136 1.00
83_D 92_K 2.135 1.00
4_G 31_T 2.132 1.00
201_L 224_R 2.102 1.00
104_V 299_L 2.058 1.00
7_I 18_V 2.039 1.00
205_Q 221_D 2.031 1.00
154_S 169_L 2.005 1.00
175_S 186_S 2 1.00
217_Q 227_E 1.997 1.00
360_V 365_M 1.969 1.00
110_S 238_R 1.959 1.00
86_A 268_I 1.926 1.00
210_E 217_Q 1.896 1.00
219_T 225_N 1.892 1.00
269_Y 298_N 1.889 1.00
168_T 199_H 1.882 1.00
207_Q 219_T 1.866 1.00
33_I 98_W 1.834 1.00
295_L 299_L 1.808 1.00
183_P 187_S 1.778 1.00
29_P 74_H 1.74 1.00
143_R 168_T 1.735 1.00
250_T 264_S 1.71 1.00
102_K 269_Y 1.692 1.00
107_T 274_C 1.69 1.00
201_L 204_S 1.69 1.00
292_A 296_A 1.684 1.00
8_I 105_L 1.675 1.00
262_Q 266_T 1.67 1.00
322_L 348_G 1.665 1.00
190_Q 200_L 1.643 1.00
149_G 176_I 1.629 1.00
140_D 165_K 1.627 1.00
252_N 276_E 1.616 1.00
93_S 98_W 1.612 1.00
204_S 222_R 1.606 1.00
192_R 195_E 1.604 1.00
161_C 166_A 1.603 1.00
85_D 90_V 1.6 1.00
207_Q 221_D 1.588 1.00
144_V 160_F 1.572 1.00
161_C 198_V 1.552 1.00
3_N 29_P 1.551 1.00
104_V 271_L 1.519 1.00
5_I 104_V 1.5 1.00
122_M 209_L 1.495 1.00
20_N 297_K 1.493 1.00
149_G 171_D 1.475 1.00
190_Q 202_L 1.465 1.00
259_S 305_P 1.464 1.00
143_R 227_E 1.457 1.00
87_E 90_V 1.442 1.00
83_D 246_R 1.437 1.00
171_D 202_L 1.432 1.00
6_V 100_Y 1.418 1.00
144_V 165_K 1.418 1.00
142_R 166_A 1.412 1.00
29_P 76_F 1.41 1.00
102_K 299_L 1.406 0.99
6_V 31_T 1.387 0.99
209_L 231_V 1.38 0.99
194_T 199_H 1.372 0.99
191_H 194_T 1.362 0.99
265_N 268_I 1.362 0.99
123_L 230_A 1.359 0.99
76_F 96_N 1.347 0.99
78_Q 93_S 1.344 0.99
296_A 300_L 1.342 0.99
24_Q 297_K 1.34 0.99
105_L 274_C 1.33 0.99
321_P 351_D 1.325 0.99
175_S 183_P 1.321 0.99
262_Q 267_D 1.32 0.99
294_V 298_N 1.3 0.99
191_H 195_E 1.3 0.99
263_T 270_A 1.297 0.99
261_L 275_A 1.279 0.99
142_R 229_D 1.276 0.99
8_I 80_W 1.274 0.99
55_R 58_D 1.271 0.99
76_F 98_W 1.27 0.99
147_V 231_V 1.27 0.99
347_R 358_F 1.269 0.99
170_I 201_L 1.26 0.99
204_S 221_D 1.259 0.99
80_W 94_Q 1.253 0.99
144_V 230_A 1.249 0.99
220_L 226_I 1.239 0.98
10_S 34_A 1.234 0.98
170_I 220_L 1.234 0.98
176_I 202_L 1.233 0.98
121_L 211_K 1.232 0.98
162_R 196_M 1.226 0.98
261_L 295_L 1.225 0.98
81_V 92_K 1.225 0.98
33_I 93_S 1.222 0.98
20_N 24_Q 1.22 0.98
21_I 296_A 1.219 0.98
17_L 295_L 1.2 0.98
187_S 190_Q 1.198 0.98
170_I 226_I 1.196 0.98
6_V 29_P 1.194 0.98
123_L 137_Q 1.186 0.98
124_T 127_S 1.181 0.98
169_L 200_L 1.16 0.97
255_V 270_A 1.159 0.97
204_S 220_L 1.158 0.97
295_L 298_N 1.157 0.97
252_N 256_C 1.142 0.97
260_Y 298_N 1.137 0.97
257_V 275_A 1.122 0.97
329_Q 362_E 1.105 0.96
154_S 317_T 1.105 0.96
257_V 270_A 1.098 0.96
212_T 217_Q 1.098 0.96
270_A 274_C 1.097 0.96
5_I 26_A 1.093 0.96
17_L 271_L 1.088 0.96
31_T 76_F 1.084 0.96
251_I 256_C 1.08 0.95
14_A 18_V 1.075 0.95
170_I 204_S 1.075 0.95
145_L 226_I 1.059 0.95
8_I 107_T 1.056 0.95
103_L 268_I 1.054 0.95
106_A 271_L 1.052 0.95
33_I 76_F 1.047 0.94
13_A 288_I 1.044 0.94
17_L 292_A 1.043 0.94
109_A 237_L 1.036 0.94
153_G 171_D 1.035 0.94
212_T 215_G 1.034 0.94
255_V 274_C 1.034 0.94
3_N 76_F 1.033 0.94
201_L 226_I 1.031 0.94
48_H 51_S 1.027 0.94
65_G 77_P 1.027 0.94
262_Q 298_N 1.013 0.93
185_V 344_M 1.01 0.93
18_V 73_L 1.008 0.93
188_R 361_S 1.007 0.93
271_L 295_L 1.005 0.93
7_I 14_A 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2v3aA111000.206Contact Map0.77
1q1rA20.98671000.282Contact Map0.784
3ef6A10.98411000.283Contact Map0.75
4fx9A20.9921000.284Contact Map0.685
3oc4A20.98411000.291Contact Map0.801
3ntdA20.98411000.291Contact Map0.812
3l8kA20.96291000.292Contact Map0.743
3iwaA10.99731000.292Contact Map0.751
1xhcA10.94691000.294Contact Map0.745
3kljA10.94691000.295Contact Map0.725
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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