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OPENSEQ.org
DHNA - NADH dehydrogenase
UniProt: P00393 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10649
Length: 434 (413)
Sequences: 3862
Seq/Len: 9.35
DHNA
Paralog alert: 0.59 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: DHNA DLDH GSHR HCAD NORW STHA TRXB YKGC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
92_K 309_D 6.552 1.00
299_E 303_Q 5.017 1.00
7_K 35_K 4.969 1.00
10_I 21_A 4.968 1.00
88_D 91_A 4.348 1.00
39_V 113_I 3.903 1.00
7_K 37_T 3.697 1.00
20_M 119_V 3.525 1.00
210_N 242_R 3.294 1.00
233_H 237_T 3.193 1.00
212_T 244_L 3.114 1.00
89_R 310_I 3.102 1.00
41_R 83_S 3.007 1.00
251_S 258_H 2.969 1.00
174_A 267_A 2.878 1.00
93_T 112_K 2.843 1.00
256_G 264_Y 2.809 1.00
174_A 257_L 2.771 1.00
132_P 251_S 2.691 1.00
216_A 248_M 2.682 1.00
35_K 78_Q 2.68 1.00
89_R 307_D 2.646 1.00
244_L 263_E 2.643 1.00
9_V 94_I 2.596 1.00
11_V 120_M 2.593 1.00
16_G 313_I 2.447 1.00
327_V 333_A 2.376 1.00
172_N 212_T 2.363 1.00
86_D 95_T 2.298 1.00
6_K 117_T 2.284 1.00
93_T 114_A 2.273 1.00
219_R 229_S 2.261 1.00
248_M 260_K 2.238 1.00
172_N 210_N 2.201 1.00
11_V 122_L 2.185 1.00
253_D 258_H 2.164 1.00
83_S 97_A 2.152 1.00
341_A 345_I 2.145 1.00
267_A 270_M 2.114 1.00
178_G 220_I 2.086 1.00
258_H 264_Y 2.085 1.00
296_L 312_A 1.952 1.00
82_G 96_I 1.924 1.00
117_T 309_D 1.924 1.00
174_A 214_V 1.913 1.00
119_V 313_I 1.899 1.00
137_N 254_E 1.89 1.00
10_I 17_G 1.884 1.00
340_C 344_N 1.879 1.00
125_T 280_D 1.867 1.00
212_T 242_R 1.864 1.00
13_G 40_D 1.852 1.00
117_T 311_Y 1.827 1.00
95_T 112_K 1.824 1.00
226_P 230_A 1.807 1.00
338_A 342_M 1.76 1.00
118_L 310_I 1.755 1.00
7_K 116_D 1.745 1.00
115_Y 118_L 1.731 1.00
250_T 260_K 1.715 1.00
253_D 256_G 1.707 1.00
9_V 113_I 1.706 1.00
82_G 103_K 1.705 1.00
311_Y 354_L 1.694 1.00
7_K 114_A 1.682 1.00
311_Y 348_Q 1.673 1.00
218_E 246_Q 1.665 1.00
122_L 316_C 1.651 1.00
8_I 34_A 1.644 1.00
119_V 345_I 1.618 1.00
125_T 277_K 1.618 1.00
304_T 312_A 1.602 1.00
96_I 103_K 1.601 1.00
178_G 215_E 1.6 1.00
11_V 94_I 1.595 1.00
39_V 96_I 1.579 1.00
234_N 237_T 1.574 1.00
307_D 310_I 1.573 1.00
252_A 270_M 1.57 1.00
230_A 234_N 1.555 1.00
291_N 295_Q 1.521 1.00
127_N 277_K 1.5 1.00
297_V 305_T 1.494 1.00
175_I 186_S 1.493 1.00
96_I 113_I 1.492 1.00
253_D 264_Y 1.483 1.00
88_D 93_T 1.483 1.00
60_D 63_V 1.475 1.00
85_I 97_A 1.445 1.00
154_M 173_I 1.445 1.00
82_G 97_A 1.444 1.00
17_G 121_A 1.442 1.00
247_T 261_D 1.439 1.00
20_M 338_A 1.438 1.00
86_D 284_D 1.435 1.00
89_R 115_Y 1.408 0.99
250_T 258_H 1.395 0.99
17_G 21_A 1.395 0.99
139_I 153_E 1.381 0.99
233_H 245_T 1.381 0.99
20_M 341_A 1.38 0.99
259_T 265_I 1.376 0.99
290_T 296_L 1.365 0.99
11_V 84_V 1.361 0.99
39_V 94_I 1.345 0.99
347_A 352_K 1.319 0.99
117_T 349_M 1.319 0.99
218_E 226_P 1.314 0.99
214_V 244_L 1.305 0.99
233_H 243_V 1.304 0.99
230_A 233_H 1.297 0.99
300_P 356_N 1.297 0.99
186_S 211_V 1.293 0.99
183_V 213_L 1.276 0.99
131_T 134_V 1.26 0.98
121_A 313_I 1.249 0.98
289_E 297_V 1.246 0.98
88_D 95_T 1.238 0.98
122_L 281_F 1.236 0.98
91_A 112_K 1.233 0.98
90_E 307_D 1.221 0.98
289_E 306_R 1.22 0.98
133_G 251_S 1.22 0.98
8_I 345_I 1.215 0.98
117_T 348_Q 1.213 0.98
236_L 241_V 1.209 0.98
225_P 376_S 1.205 0.98
249_V 257_L 1.198 0.98
115_Y 309_D 1.195 0.98
215_E 245_T 1.193 0.98
342_M 346_L 1.191 0.97
11_V 39_V 1.186 0.97
36_I 77_F 1.183 0.97
181_T 273_A 1.183 0.97
13_G 68_Y 1.181 0.97
173_I 269_L 1.176 0.97
37_T 78_Q 1.173 0.97
40_D 79_F 1.168 0.97
221_L 232_A 1.163 0.97
21_A 77_F 1.159 0.97
311_Y 344_N 1.151 0.97
259_T 262_G 1.148 0.97
244_L 247_T 1.137 0.96
23_Q 343_N 1.13 0.96
154_M 189_L 1.124 0.96
219_R 226_P 1.123 0.96
348_Q 354_L 1.119 0.96
190_H 241_V 1.119 0.96
150_F 269_L 1.116 0.96
214_V 265_I 1.116 0.96
97_A 104_G 1.111 0.96
85_I 95_T 1.105 0.96
296_L 304_T 1.101 0.95
277_K 283_K 1.1 0.95
334_A 338_A 1.095 0.95
158_F 209_L 1.094 0.95
46_L 51_L 1.089 0.95
247_T 260_K 1.086 0.95
9_V 39_V 1.086 0.95
340_C 356_N 1.081 0.95
187_A 368_L 1.079 0.95
173_I 189_L 1.078 0.95
303_Q 308_P 1.076 0.95
20_M 313_I 1.076 0.95
8_I 24_L 1.076 0.95
212_T 265_I 1.075 0.95
37_T 80_Q 1.066 0.94
141_L 150_F 1.064 0.94
391_R 394_R 1.063 0.94
220_I 245_T 1.058 0.94
214_V 259_T 1.058 0.94
15_A 331_A 1.055 0.94
303_Q 348_Q 1.053 0.94
313_I 341_A 1.052 0.94
9_V 37_T 1.048 0.94
117_T 345_I 1.047 0.94
213_L 243_V 1.038 0.93
259_T 263_E 1.023 0.93
9_V 118_L 1.017 0.92
13_G 38_L 1.013 0.92
175_I 185_L 1.01 0.92
17_G 38_L 1.007 0.92
231_A 389_E 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g6hA20.95851000.28Contact Map0.831
3sx6A10.92171000.449Contact Map0.756
3h28A60.91241000.451Contact Map0.797
3h8lA20.8711000.472Contact Map0.755
2gqwA10.86181000.493Contact Map0.716
1q1rA20.8711000.506Contact Map0.776
3fg2P10.86411000.509Contact Map0.792
1xhcA10.82261000.509Contact Map0.774
3lxdA10.87561000.512Contact Map0.698
3kljA10.83411000.515Contact Map0.73
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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