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OPENSEQ.org

FSAB - Fructose-6-phosphate aldolase 2
UniProt: P32669 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11905
Length: 220 (216)
Sequences: 1789
Seq/Len: 8.28

FSAB
Paralog alert: 0.36 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FSAA FSAB TALA TALB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
73_K 102_E 5.982 1.00
64_D 67_G 4.717 1.00
68_M 86_I 3.499 1.00
69_V 98_I 3.301 1.00
94_A 97_K 2.749 1.00
66_Q 70_E 2.723 1.00
2_E 161_M 2.662 1.00
136_D 172_Q 2.613 1.00
205_E 209_H 2.34 1.00
88_V 111_V 2.339 1.00
96_I 108_G 2.337 1.00
45_R 48_K 2.156 1.00
9_N 35_S 2.141 1.00
150_Q 162_V 2.139 1.00
126_K 161_M 2.077 1.00
202_S 206_K 2.038 1.00
97_K 101_K 2.009 1.00
65_A 98_I 1.994 1.00
15_R 192_Q 1.993 1.00
73_K 98_I 1.921 1.00
148_E 178_L 1.881 1.00
189_D 193_Q 1.88 1.00
150_Q 154_E 1.865 1.00
144_R 148_E 1.851 1.00
117_G 149_L 1.825 1.00
23_A 122_L 1.816 1.00
30_S 210_D 1.8 1.00
147_Q 151_T 1.783 1.00
70_E 74_R 1.78 1.00
209_H 213_A 1.759 1.00
209_H 212_N 1.737 1.00
73_K 104_I 1.694 1.00
74_R 77_D 1.651 1.00
161_M 183_S 1.651 1.00
105_T 126_K 1.631 1.00
11_A 14_E 1.608 1.00
86_I 96_I 1.588 1.00
114_A 152_L 1.482 1.00
98_I 102_E 1.482 1.00
143_I 176_C 1.471 0.99
44_P 48_K 1.469 0.99
72_A 99_L 1.404 0.99
114_A 118_L 1.402 0.99
63_R 204_I 1.395 0.99
14_E 45_R 1.377 0.99
107_L 129_A 1.363 0.99
58_A 75_L 1.361 0.99
10_V 42_V 1.359 0.99
38_S 41_E 1.34 0.99
59_Q 131_Y 1.337 0.99
69_V 73_K 1.336 0.99
106_T 126_K 1.303 0.98
164_A 167_F 1.3 0.98
72_A 84_V 1.3 0.98
32_I 39_I 1.298 0.98
202_S 205_E 1.288 0.98
11_A 15_R 1.277 0.98
90_S 195_L 1.274 0.98
141_D 144_R 1.272 0.98
61_M 208_E 1.267 0.98
116_Q 200_V 1.257 0.98
71_E 74_R 1.256 0.98
65_A 94_A 1.253 0.98
39_I 43_L 1.243 0.98
163_L 183_S 1.24 0.98
65_A 69_V 1.232 0.98
10_V 56_L 1.231 0.97
37_E 42_V 1.214 0.97
70_E 73_K 1.214 0.97
63_R 91_E 1.21 0.97
25_V 46_L 1.191 0.97
40_W 43_L 1.19 0.97
107_L 131_Y 1.177 0.96
211_W 214_A 1.177 0.96
88_V 108_G 1.174 0.96
164_A 176_C 1.173 0.96
186_L 191_A 1.149 0.96
128_V 153_L 1.143 0.96
75_L 78_A 1.138 0.96
57_F 107_L 1.136 0.95
58_A 82_I 1.132 0.95
133_N 137_A 1.128 0.95
65_A 91_E 1.126 0.95
16_L 188_L 1.123 0.95
175_D 178_L 1.112 0.95
114_A 148_E 1.108 0.95
111_V 153_L 1.108 0.95
137_A 168_K 1.095 0.94
9_N 12_E 1.091 0.94
63_R 208_E 1.091 0.94
136_D 142_G 1.089 0.94
115_A 174_L 1.085 0.94
67_G 70_E 1.073 0.93
118_L 155_M 1.071 0.93
133_N 168_K 1.061 0.93
122_L 158_P 1.06 0.93
118_L 152_L 1.038 0.92
110_A 131_Y 1.038 0.92
143_I 175_D 1.031 0.91
176_C 211_W 1.03 0.91
34_A 189_D 1.011 0.90
121_A 153_L 1.011 0.90
59_Q 129_A 1.01 0.90
56_L 79_I 1.002 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1l6wA1011000.006Contact Map0.772
3r8rA200.95911000.012Contact Map0.737
1vpxA200.99091000.014Contact Map0.843
3s1xA50.99091000.019Contact Map0.749
1wx0A100.97271000.021Contact Map0.82
3cwnA20.96361000.174Contact Map0.695
3tkfA20.96361000.181Contact Map0.747
3m16A10.96361000.182Contact Map0.689
3cq0A20.96361000.183Contact Map0.737
3hjzA10.96361000.185Contact Map0.714

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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