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OPENSEQ.org
TALB - Transaldolase B
UniProt: P0A870 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11556
Length: 317 (317)
Sequences: 1159
Seq/Len: 3.66
TALB
Paralog alert: 0.34 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FSAA FSAB TALA TALB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
108_S 133_L 4.577 1.00
141_R 144_E 4.385 1.00
113_K 149_E 4.049 1.00
109_I 145_Q 3.897 1.00
120_N 126_N 3.583 1.00
183_L 232_E 3.105 1.00
106_E 110_A 3.034 1.00
84_E 87_K 2.635 1.00
235_E 262_K 2.565 1.00
278_E 282_L 2.418 1.00
234_L 259_I 2.384 1.00
135_S 158_L 2.381 1.00
37_S 305_D 2.306 1.00
22_A 25_K 2.184 1.00
105_T 145_Q 2.176 1.00
27_Y 250_K 2.118 1.00
285_H 292_V 2.093 1.00
103_Y 138_Q 2.071 1.00
120_N 125_S 2.064 1.00
277_T 280_E 2.054 1.00
49_R 316_L 2.037 1.00
250_K 254_E 1.989 1.00
161_F 165_R 1.951 1.00
113_K 151_I 1.914 1.00
137_W 166_A 1.913 1.00
65_D 68_Q 1.874 1.00
152_N 173_F 1.873 1.00
113_K 145_Q 1.771 0.99
111_K 114_R 1.764 0.99
100_R 310_E 1.734 0.99
144_E 148_K 1.711 0.99
145_Q 149_E 1.678 0.99
133_L 146_L 1.676 0.99
311_K 315_D 1.668 0.99
292_V 296_A 1.668 0.99
117_K 120_N 1.666 0.99
221_V 241_R 1.646 0.99
104_D 107_A 1.64 0.99
196_A 199_E 1.623 0.98
297_E 301_K 1.6 0.98
193_K 199_E 1.599 0.98
296_A 300_R 1.583 0.98
109_I 113_K 1.517 0.97
143_A 155_L 1.517 0.97
163_Q 295_L 1.515 0.97
313_I 316_L 1.51 0.97
75_D 111_K 1.508 0.97
114_R 117_K 1.499 0.97
165_R 215_E 1.482 0.97
4_K 257_G 1.482 0.97
261_R 266_T 1.448 0.96
193_K 196_A 1.441 0.96
117_K 121_D 1.438 0.96
59_A 73_A 1.419 0.96
4_K 255_S 1.418 0.96
185_W 293_D 1.398 0.95
280_E 284_Q 1.377 0.95
5_L 14_V 1.373 0.94
289_P 293_D 1.372 0.94
220_T 224_G 1.372 0.94
76_K 80_N 1.371 0.94
72_D 114_R 1.37 0.94
105_T 141_R 1.361 0.94
4_K 7_S 1.355 0.94
283_W 303_A 1.347 0.94
300_R 304_I 1.345 0.94
307_E 311_K 1.333 0.93
212_Y 215_E 1.325 0.93
95_T 119_Y 1.322 0.93
63_S 72_D 1.319 0.93
34_T 82_G 1.315 0.93
23_A 26_L 1.312 0.93
261_R 264_S 1.293 0.92
66_R 314_G 1.291 0.92
261_R 265_Y 1.29 0.92
116_I 129_I 1.289 0.92
165_R 212_Y 1.285 0.91
53_D 316_L 1.279 0.91
58_W 62_Q 1.277 0.91
197_P 231_G 1.275 0.91
301_K 304_I 1.27 0.91
234_L 255_S 1.266 0.91
138_Q 282_L 1.262 0.90
3_D 6_T 1.26 0.90
304_I 307_E 1.26 0.90
122_A 207_S 1.245 0.90
41_N 301_K 1.244 0.90
4_K 234_L 1.236 0.89
210_Y 266_T 1.234 0.89
265_Y 268_E 1.22 0.88
304_I 308_K 1.218 0.88
161_F 208_E 1.212 0.88
198_A 207_S 1.195 0.87
234_L 257_G 1.192 0.87
189_N 192_K 1.189 0.87
286_N 289_P 1.189 0.87
101_L 107_A 1.18 0.86
103_Y 282_L 1.177 0.86
50_K 54_D 1.171 0.85
106_E 109_I 1.168 0.85
76_K 118_L 1.166 0.85
182_I 205_S 1.165 0.85
154_N 178_F 1.162 0.85
83_L 87_K 1.161 0.85
154_N 157_L 1.157 0.85
207_S 211_Q 1.152 0.84
198_A 235_E 1.143 0.84
147_E 152_N 1.14 0.83
154_N 176_S 1.138 0.83
74_T 78_A 1.134 0.83
83_L 122_A 1.128 0.82
271_A 275_R 1.123 0.82
135_S 155_L 1.116 0.82
63_S 68_Q 1.116 0.82
3_D 253_A 1.11 0.81
190_T 193_K 1.104 0.81
64_N 72_D 1.087 0.79
96_E 178_F 1.08 0.78
311_K 314_G 1.068 0.77
9_R 30_Q 1.065 0.77
177_P 209_I 1.063 0.77
20_D 246_P 1.061 0.77
155_L 172_V 1.056 0.76
158_L 213_Y 1.051 0.76
229_N 233_I 1.048 0.76
132_K 243_T 1.044 0.75
41_N 247_A 1.042 0.75
80_N 83_L 1.042 0.75
243_T 302_F 1.039 0.75
32_A 85_I 1.037 0.74
43_A 78_A 1.036 0.74
178_F 298_G 1.035 0.74
75_D 114_R 1.034 0.74
270_K 274_A 1.033 0.74
250_K 253_A 1.027 0.73
37_S 41_N 1.023 0.73
199_E 229_N 1.023 0.73
14_V 244_I 1.011 0.72
39_I 81_I 1.009 0.72
276_I 280_E 1.007 0.71
286_N 292_V 1.005 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cwnA20.99681000.091Contact Map0.739
3hjzA10.99681000.091Contact Map0.709
3cq0A20.99371000.094Contact Map0.735
3m16A10.99681000.095Contact Map0.701
3tkfA20.99681000.101Contact Map0.754
2e1dA20.99681000.102Contact Map0.724
3clmA10.92741000.221Contact Map0.544
3r5eA10.94011000.222Contact Map0.586
1wx0A100.67821000.407Contact Map0.728
1vpxA200.70351000.417Contact Map0.76
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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