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OPENSEQ.org
DCP - Peptidyl-dipeptidase dcp
UniProt: P24171 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10212
Length: 681 (674)
Sequences: 2374
Seq/Len: 3.52
DCP
Paralog alert: 0.60 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: DCP OPDA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
164_E 264_R 7.198 1.00
240_E 244_I 6.016 1.00
157_K 271_Q 5.405 1.00
661_R 667_A 5.026 1.00
280_H 283_A 4.275 1.00
279_P 283_A 4.036 1.00
234_R 339_F 3.828 1.00
409_A 479_L 3.666 1.00
151_A 154_D 3.487 1.00
194_A 234_R 3.479 1.00
33_D 98_E 3.21 1.00
192_Q 235_D 3.028 1.00
641_L 645_E 2.969 1.00
654_E 662_Q 2.855 1.00
29_R 94_Q 2.848 1.00
34_E 38_Q 2.799 1.00
6_P 27_H 2.77 1.00
40_R 105_D 2.733 1.00
237_A 240_E 2.712 1.00
161_L 268_I 2.665 1.00
628_W 642_R 2.665 1.00
530_D 534_Q 2.556 1.00
654_E 658_R 2.54 1.00
309_R 313_S 2.522 1.00
129_D 132_S 2.453 1.00
628_W 632_Q 2.432 1.00
645_E 649_S 2.357 1.00
21_D 389_P 2.344 1.00
384_E 396_R 2.342 1.00
378_F 505_N 2.186 1.00
110_G 114_A 2.184 1.00
642_R 646_A 2.18 1.00
117_D 121_Q 2.158 1.00
646_A 662_Q 2.154 1.00
278_F 287_A 2.137 1.00
390_V 395_V 2.13 1.00
575_D 579_R 2.12 1.00
462_W 510_T 2.079 1.00
654_E 659_L 2.076 1.00
175_R 258_T 2.075 1.00
383_V 401_F 2.052 1.00
383_V 399_E 2.03 1.00
550_E 554_A 2.025 1.00
190_I 201_I 2.012 1.00
375_N 381_K 1.999 1.00
631_E 664_R 1.955 1.00
572_D 575_D 1.95 1.00
39_K 102_L 1.919 1.00
165_A 265_L 1.91 1.00
5_N 8_L 1.879 1.00
318_S 348_K 1.872 1.00
230_L 242_L 1.87 1.00
234_R 343_Q 1.838 0.99
157_K 160_V 1.822 0.99
295_E 299_N 1.82 0.99
292_K 655_D 1.771 0.99
226_Q 242_L 1.768 0.99
281_Y 609_A 1.767 0.99
164_E 167_T 1.766 0.99
198_E 202_A 1.753 0.99
34_E 37_Q 1.746 0.99
132_S 485_Y 1.739 0.99
33_D 37_Q 1.731 0.99
186_V 218_L 1.727 0.99
24_A 27_H 1.725 0.99
5_N 27_H 1.717 0.99
270_A 274_T 1.705 0.99
47_A 109_N 1.697 0.99
516_A 530_D 1.691 0.99
135_L 488_L 1.684 0.99
145_L 287_A 1.676 0.99
364_T 368_E 1.676 0.99
211_K 218_L 1.674 0.99
113_F 144_V 1.67 0.99
219_I 242_L 1.666 0.99
90_R 94_Q 1.661 0.99
650_R 659_L 1.656 0.99
189_D 192_Q 1.652 0.99
56_N 60_L 1.651 0.99
384_E 398_W 1.648 0.99
110_G 152_Q 1.647 0.98
204_A 219_I 1.632 0.98
168_L 261_I 1.623 0.98
385_R 399_E 1.62 0.98
205_A 209_R 1.614 0.98
365_V 465_V 1.608 0.98
46_I 58_T 1.605 0.98
311_R 314_D 1.593 0.98
512_P 516_A 1.583 0.98
101_E 163_T 1.572 0.98
37_Q 41_A 1.565 0.98
637_R 641_L 1.559 0.98
536_M 539_A 1.558 0.98
29_R 33_D 1.552 0.98
443_I 475_T 1.55 0.98
38_Q 68_L 1.549 0.98
260_A 264_R 1.548 0.98
500_F 625_G 1.54 0.97
197_S 232_E 1.539 0.97
576_F 596_R 1.537 0.97
19_H 22_Q 1.536 0.97
134_R 138_V 1.532 0.97
59_I 116_V 1.527 0.97
317_A 321_A 1.514 0.97
117_D 144_V 1.503 0.97
41_A 45_A 1.502 0.97
578_L 582_V 1.499 0.97
361_E 364_T 1.496 0.97
636_T 639_N 1.494 0.97
44_A 48_L 1.492 0.97
60_L 132_S 1.49 0.97
632_Q 636_T 1.485 0.97
534_Q 538_N 1.479 0.96
157_K 161_L 1.476 0.96
395_V 412_Y 1.464 0.96
113_F 117_D 1.453 0.96
192_Q 241_K 1.451 0.96
283_A 294_P 1.449 0.96
223_N 227_Q 1.448 0.96
272_Q 281_Y 1.433 0.96
110_G 155_K 1.431 0.96
33_D 94_Q 1.427 0.95
160_V 164_E 1.419 0.95
283_A 295_E 1.416 0.95
236_R 333_Q 1.416 0.95
325_K 347_E 1.41 0.95
320_Q 324_D 1.407 0.95
429_N 432_E 1.393 0.95
219_I 225_T 1.39 0.95
397_V 410_L 1.38 0.94
427_M 478_G 1.38 0.94
176_L 601_A 1.38 0.94
93_E 174_Q 1.38 0.94
579_R 582_V 1.378 0.94
293_T 296_A 1.377 0.94
445_N 475_T 1.374 0.94
320_Q 331_S 1.371 0.94
624_D 666_K 1.369 0.94
616_L 677_R 1.369 0.94
638_E 642_R 1.367 0.94
551_L 554_A 1.365 0.94
285_K 289_Q 1.365 0.94
456_E 523_Q 1.363 0.94
322_V 347_E 1.363 0.94
156_A 160_V 1.362 0.94
226_Q 230_L 1.36 0.94
428_G 444_Y 1.357 0.94
113_F 140_H 1.354 0.93
237_A 241_K 1.353 0.93
372_W 517_R 1.352 0.93
186_V 213_L 1.352 0.93
644_R 649_S 1.348 0.93
658_R 662_Q 1.342 0.93
512_P 530_D 1.338 0.93
262_I 561_W 1.337 0.93
643_F 648_L 1.335 0.93
133_I 137_E 1.334 0.93
117_D 140_H 1.329 0.93
144_V 149_K 1.324 0.92
362_L 460_L 1.322 0.92
54_D 61_A 1.317 0.92
292_K 296_A 1.315 0.92
632_Q 638_E 1.311 0.92
229_A 233_M 1.31 0.92
67_E 432_E 1.305 0.92
264_R 267_E 1.3 0.92
650_R 654_E 1.299 0.91
302_R 583_A 1.299 0.91
35_G 72_V 1.291 0.91
190_I 217_W 1.286 0.91
380_I 408_L 1.285 0.91
154_D 157_K 1.284 0.91
78_A 444_Y 1.284 0.91
367_N 396_R 1.279 0.91
482_R 649_S 1.272 0.90
450_Q 464_D 1.269 0.90
44_A 111_E 1.268 0.90
240_E 335_W 1.268 0.90
355_Q 358_P 1.267 0.90
378_F 643_F 1.267 0.90
122_R 126_L 1.264 0.90
188_N 217_W 1.264 0.90
407_G 410_L 1.26 0.90
376_Q 517_R 1.259 0.90
352_D 355_Q 1.258 0.90
229_A 242_L 1.25 0.89
559_M 612_Y 1.244 0.89
373_T 505_N 1.244 0.89
344_V 542_F 1.236 0.89
494_P 656_L 1.231 0.88
282_A 610_A 1.221 0.88
317_A 320_Q 1.217 0.88
140_H 144_V 1.215 0.87
253_N 257_D 1.211 0.87
303_E 307_A 1.21 0.87
452_P 458_A 1.21 0.87
278_F 284_W 1.209 0.87
560_R 576_F 1.209 0.87
63_E 487_T 1.202 0.87
402_D 408_L 1.199 0.86
58_T 115_R 1.198 0.86
461_L 464_D 1.197 0.86
129_D 484_R 1.196 0.86
117_D 149_K 1.194 0.86
564_L 572_D 1.193 0.86
42_E 66_G 1.189 0.86
374_A 472_F 1.187 0.86
657_E 668_P 1.186 0.86
185_L 241_K 1.183 0.85
372_W 376_Q 1.181 0.85
279_P 295_E 1.18 0.85
380_I 480_F 1.177 0.85
221_L 245_A 1.169 0.85
521_H 524_S 1.163 0.84
344_V 348_K 1.162 0.84
308_A 548_M 1.162 0.84
199_Q 354_A 1.162 0.84
309_R 583_A 1.159 0.84
78_A 428_G 1.159 0.84
398_W 413_G 1.158 0.84
27_H 30_P 1.155 0.84
298_L 559_M 1.155 0.84
312_A 549_S 1.153 0.83
27_H 31_A 1.145 0.83
152_Q 155_K 1.144 0.83
425_A 467_T 1.143 0.83
579_R 583_A 1.142 0.83
397_V 404_N 1.142 0.83
233_M 238_T 1.139 0.82
500_F 504_I 1.138 0.82
309_R 549_S 1.137 0.82
37_Q 40_R 1.134 0.82
35_G 68_L 1.128 0.82
145_L 284_W 1.127 0.81
670_I 673_M 1.127 0.81
382_F 400_I 1.127 0.81
102_L 105_D 1.125 0.81
467_T 602_H 1.125 0.81
297_A 559_M 1.124 0.81
184_G 218_L 1.121 0.81
313_S 317_A 1.117 0.81
576_F 580_A 1.116 0.81
632_Q 639_N 1.115 0.81
25_N 87_E 1.11 0.80
139_I 487_T 1.109 0.80
251_E 254_D 1.103 0.80
646_A 654_E 1.103 0.80
435_T 484_R 1.102 0.79
368_E 372_W 1.099 0.79
417_A 448_N 1.099 0.79
40_R 44_A 1.092 0.79
38_Q 41_A 1.091 0.78
45_A 61_A 1.09 0.78
168_L 275_L 1.088 0.78
478_G 491_T 1.088 0.78
544_K 548_M 1.087 0.78
364_T 520_R 1.087 0.78
246_G 249_R 1.085 0.78
657_E 667_A 1.084 0.78
556_L 584_E 1.077 0.77
498_V 501_P 1.075 0.77
360_F 465_V 1.074 0.77
280_H 563_C 1.073 0.77
81_A 426_W 1.071 0.77
5_N 31_A 1.07 0.77
254_D 574_D 1.068 0.76
291_A 616_L 1.068 0.76
137_E 141_Q 1.067 0.76
391_Y 395_V 1.061 0.76
158_L 162_N 1.061 0.76
161_L 165_A 1.057 0.75
23_I 27_H 1.056 0.75
324_D 329_G 1.056 0.75
32_F 73_T 1.05 0.75
551_L 616_L 1.049 0.75
15_Y 407_G 1.043 0.74
29_R 98_E 1.043 0.74
40_R 101_E 1.042 0.74
488_L 652_N 1.042 0.74
206_E 210_E 1.039 0.74
341_A 543_N 1.036 0.73
463_D 466_I 1.035 0.73
135_L 485_Y 1.035 0.73
481_A 491_T 1.034 0.73
162_N 165_A 1.034 0.73
299_N 303_E 1.033 0.73
204_A 225_T 1.033 0.73
43_I 47_A 1.03 0.73
44_A 47_A 1.03 0.73
362_L 416_F 1.029 0.73
470_H 615_Y 1.029 0.73
223_N 246_G 1.027 0.72
286_I 294_P 1.027 0.72
367_N 413_G 1.027 0.72
243_F 247_W 1.026 0.72
80_T 92_D 1.024 0.72
494_P 497_F 1.024 0.72
350_D 449_Y 1.022 0.72
443_I 478_G 1.022 0.72
531_E 534_Q 1.021 0.72
32_F 95_F 1.019 0.71
196_M 204_A 1.018 0.71
80_T 88_L 1.018 0.71
627_Q 631_E 1.017 0.71
265_L 604_F 1.016 0.71
499_E 502_S 1.015 0.71
516_A 533_Q 1.011 0.71
183_G 241_K 1.01 0.71
502_S 602_H 1.009 0.70
113_F 149_K 1.008 0.70
411_F 445_N 1.007 0.70
236_R 335_W 1.007 0.70
207_A 211_K 1.006 0.70
42_E 46_I 1.005 0.70
70_T 74_S 1.005 0.70
20_F 23_I 1.003 0.70
375_N 382_F 1.003 0.70
94_Q 98_E 1.002 0.70
633_G 638_E 1.001 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ka7A10.98681000.106Contact Map0.74
1y79110.99561000.117Contact Map0.721
2o36A10.95741000.14Contact Map0.675
2o3eA10.96771000.148Contact Map0.658
2qr4A20.80321000.523Contact Map0.512
3sksA10.7931000.528Contact Map0.503
3ahnA20.78711000.532Contact Map0.533
3ce2A10.82971000.533Contact Map0.52
3nxqA20.791000.555Contact Map0.509
1r42A10.79881000.569Contact Map0.478
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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