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OPENSEQ.org
OPDA - Oligopeptidase A
UniProt: P27298 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11441
Length: 680 (674)
Sequences: 2487
Seq/Len: 3.69
OPDA
Paralog alert: 0.62 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: DCP OPDA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
233_E 237_R 6.882 1.00
158_R 261_E 6.719 1.00
151_R 268_E 5.162 1.00
276_E 280_F 4.929 1.00
660_K 666_E 4.846 1.00
277_N 280_F 4.027 1.00
227_D 336_Y 3.638 1.00
188_A 227_D 3.583 1.00
145_P 148_K 3.559 1.00
640_Q 644_D 3.507 1.00
230_A 233_E 3.421 1.00
627_R 641_S 3.217 1.00
405_G 478_M 3.212 1.00
653_E 661_R 3.104 1.00
28_K 32_D 2.969 1.00
653_E 657_D 2.776 1.00
186_E 228_N 2.754 1.00
23_V 88_Q 2.747 1.00
27_T 92_L 2.594 1.00
4_P 21_H 2.532 1.00
306_R 310_E 2.52 1.00
34_R 99_W 2.514 1.00
627_R 631_E 2.457 1.00
644_D 648_S 2.439 1.00
380_E 392_R 2.422 1.00
530_K 534_D 2.404 1.00
15_S 385_D 2.355 1.00
155_I 265_L 2.323 1.00
364_N 368_E 2.221 1.00
184_E 195_L 2.207 1.00
315_Q 345_L 2.189 1.00
292_Q 296_D 2.189 1.00
379_K 397_Y 2.111 1.00
641_S 645_N 2.073 1.00
28_K 31_N 2.062 1.00
374_Y 505_M 2.011 1.00
123_N 126_Q 2.009 1.00
653_E 658_L 2.007 1.00
230_A 234_E 2.001 1.00
104_E 108_K 2 1.00
572_K 575_E 1.99 1.00
111_R 115_D 1.967 1.00
192_E 196_A 1.965 1.00
267_H 271_Q 1.963 1.00
18_L 21_H 1.954 1.00
645_N 661_R 1.954 1.00
361_K 364_N 1.947 1.00
23_V 27_T 1.945 1.00
636_R 640_Q 1.924 1.00
223_M 235_M 1.912 1.00
205_K 211_L 1.909 1.00
550_R 554_F 1.908 1.00
386_V 391_V 1.902 1.00
31_N 35_E 1.895 1.00
322_A 344_H 1.888 1.00
371_K 377_T 1.883 1.00
27_T 31_N 1.871 1.00
275_F 284_A 1.864 1.00
379_K 395_E 1.85 1.00
564_E 572_K 1.849 1.00
630_E 663_R 1.812 0.99
169_N 255_N 1.806 0.99
33_C 96_Y 1.794 0.99
199_K 203_E 1.791 0.99
139_L 284_A 1.789 0.99
151_R 154_E 1.777 0.99
32_D 62_V 1.775 0.99
227_D 340_K 1.775 0.99
461_H 510_W 1.77 0.99
104_E 146_K 1.762 0.99
159_L 262_I 1.761 0.99
575_E 579_E 1.751 0.99
368_E 371_K 1.738 0.99
50_E 54_Q 1.718 0.99
158_R 161_E 1.71 0.99
229_Q 330_Q 1.686 0.99
61_D 428_G 1.671 0.99
183_D 186_E 1.668 0.99
278_Y 608_A 1.663 0.99
431_R 483_E 1.66 0.99
41_V 103_H 1.647 0.99
631_E 635_N 1.642 0.99
212_L 235_M 1.639 0.99
127_K 131_D 1.634 0.99
649_R 658_L 1.629 0.99
574_L 596_P 1.627 0.99
314_A 318_A 1.616 0.98
318_A 321_K 1.604 0.98
35_E 39_R 1.602 0.98
328_E 588_P 1.601 0.98
637_E 641_S 1.591 0.98
40_V 52_L 1.583 0.98
3_N 6_L 1.569 0.98
257_K 261_E 1.561 0.98
219_Y 235_M 1.551 0.98
38_E 42_A 1.547 0.98
516_A 530_K 1.537 0.98
126_Q 484_T 1.537 0.98
289_E 654_E 1.532 0.98
191_P 225_Y 1.529 0.98
358_P 448_F 1.529 0.98
198_A 212_L 1.529 0.98
358_P 361_K 1.528 0.98
455_K 523_E 1.525 0.97
631_E 637_E 1.524 0.97
13_P 16_K 1.521 0.97
29_A 66_I 1.52 0.97
138_E 143_G 1.507 0.97
500_L 624_A 1.506 0.97
129_A 487_V 1.504 0.97
216_I 220_L 1.497 0.97
380_E 394_F 1.496 0.97
128_K 132_N 1.49 0.97
75_S 422_W 1.488 0.97
180_L 207_L 1.486 0.97
53_C 110_Y 1.485 0.97
425_D 428_G 1.48 0.97
27_T 88_Q 1.469 0.97
534_D 538_A 1.466 0.97
154_E 158_R 1.465 0.97
162_L 258_V 1.464 0.97
280_F 292_Q 1.462 0.97
180_L 211_L 1.462 0.97
111_R 138_E 1.453 0.96
170_V 600_S 1.453 0.96
290_N 293_Q 1.44 0.96
162_L 272_L 1.433 0.96
381_R 395_E 1.432 0.96
3_N 21_H 1.432 0.96
632_G 637_E 1.426 0.96
319_F 344_H 1.422 0.96
341_Q 345_L 1.419 0.96
657_D 661_R 1.413 0.96
559_F 609_A 1.409 0.95
280_F 291_P 1.407 0.95
368_E 517_F 1.405 0.95
95_E 157_T 1.397 0.95
259_M 561_L 1.387 0.95
512_P 516_A 1.381 0.95
296_D 300_D 1.381 0.95
366_L 468_F 1.38 0.95
314_A 317_R 1.372 0.94
310_E 314_A 1.372 0.94
300_D 304_R 1.372 0.94
104_E 149_Q 1.368 0.94
84_E 88_Q 1.365 0.94
481_R 648_S 1.365 0.94
669_L 672_M 1.364 0.94
551_Q 554_F 1.362 0.94
151_R 155_I 1.358 0.94
635_N 638_T 1.357 0.94
442_A 474_G 1.356 0.94
536_M 539_A 1.338 0.93
150_Q 154_E 1.337 0.93
649_R 653_E 1.336 0.93
656_M 667_P 1.333 0.93
261_E 264_A 1.332 0.93
23_V 92_L 1.325 0.93
87_E 168_N 1.321 0.93
423_M 477_H 1.316 0.93
391_V 408_Y 1.314 0.93
29_A 62_V 1.313 0.93
308_Q 311_K 1.303 0.92
107_Y 138_E 1.302 0.92
31_N 34_R 1.3 0.92
357_F 448_F 1.294 0.92
460_T 463_E 1.29 0.92
72_H 424_D 1.284 0.92
186_E 234_E 1.283 0.91
512_P 530_K 1.279 0.91
631_E 638_T 1.274 0.91
299_T 583_L 1.273 0.91
444_L 474_G 1.271 0.91
317_R 328_E 1.269 0.91
642_F 647_L 1.269 0.91
578_A 593_G 1.264 0.91
359_E 459_F 1.258 0.90
560_R 579_E 1.257 0.90
262_I 266_R 1.254 0.90
286_K 613_S 1.25 0.90
289_E 293_Q 1.25 0.90
403_L 406_S 1.248 0.90
269_L 278_Y 1.245 0.90
131_D 135_R 1.244 0.90
369_V 505_M 1.235 0.89
654_E 657_D 1.233 0.89
212_L 218_S 1.23 0.89
134_L 138_E 1.23 0.89
226_C 231_L 1.228 0.89
374_Y 642_F 1.227 0.89
214_L 238_A 1.225 0.89
393_F 406_S 1.218 0.88
123_N 483_E 1.211 0.88
321_K 327_D 1.21 0.88
111_R 134_L 1.209 0.88
156_A 159_L 1.208 0.88
155_I 159_L 1.207 0.88
626_S 630_E 1.206 0.88
153_G 274_G 1.203 0.88
81_E 84_E 1.202 0.88
57_A 486_G 1.198 0.87
178_T 211_L 1.189 0.87
359_E 411_L 1.178 0.86
309_G 549_L 1.178 0.86
47_Y 51_N 1.176 0.86
146_K 149_Q 1.176 0.86
236_Y 240_S 1.175 0.86
424_D 443_Y 1.173 0.86
282_S 286_K 1.173 0.86
579_E 583_L 1.172 0.86
449_N 463_E 1.163 0.85
233_E 332_W 1.162 0.85
462_D 465_I 1.162 0.85
72_H 422_W 1.16 0.85
38_E 105_G 1.155 0.85
72_H 443_Y 1.155 0.85
146_K 150_Q 1.155 0.85
275_F 281_K 1.15 0.84
643_L 648_S 1.15 0.84
376_I 404_R 1.149 0.84
368_E 372_R 1.136 0.83
148_K 151_R 1.129 0.83
494_P 655_P 1.12 0.82
295_L 299_T 1.118 0.82
54_Q 126_Q 1.114 0.82
578_A 582_K 1.113 0.81
124_T 127_K 1.11 0.81
498_V 501_P 1.109 0.81
222_V 226_C 1.107 0.81
577_L 580_I 1.107 0.81
454_G 523_E 1.106 0.81
313_L 329_L 1.106 0.81
52_L 109_A 1.103 0.81
305_A 548_I 1.102 0.81
657_D 660_K 1.101 0.80
615_L 676_Y 1.098 0.80
581_K 592_W 1.097 0.80
560_R 563_A 1.097 0.80
74_N 86_Y 1.096 0.80
372_R 517_F 1.093 0.80
620_L 667_P 1.089 0.79
451_P 457_A 1.088 0.79
37_V 41_V 1.087 0.79
357_F 464_V 1.087 0.79
279_A 609_A 1.087 0.79
531_E 534_D 1.085 0.79
259_M 573_I 1.084 0.79
623_D 665_R 1.084 0.79
304_R 674_E 1.083 0.79
349_S 352_Q 1.081 0.79
107_Y 111_R 1.081 0.79
34_R 95_E 1.078 0.79
166_Y 268_E 1.078 0.79
304_R 307_P 1.078 0.79
263_L 561_L 1.076 0.78
303_K 307_P 1.074 0.78
229_Q 326_V 1.074 0.78
302_A 583_L 1.074 0.78
656_M 666_E 1.073 0.78
229_Q 332_W 1.07 0.78
219_Y 223_M 1.069 0.78
595_F 598_A 1.067 0.78
397_Y 409_L 1.066 0.77
250_A 253_W 1.064 0.77
339_E 342_K 1.063 0.77
341_Q 542_Y 1.062 0.77
96_Y 99_W 1.061 0.77
480_T 490_I 1.061 0.77
398_D 404_R 1.059 0.77
106_L 137_F 1.057 0.77
466_T 601_H 1.055 0.76
317_R 321_K 1.054 0.76
36_N 40_V 1.053 0.76
111_R 143_G 1.053 0.76
574_L 578_A 1.049 0.76
378_A 396_L 1.048 0.76
370_V 471_F 1.047 0.76
560_R 564_E 1.046 0.76
222_V 235_M 1.046 0.76
176_G 253_W 1.042 0.75
645_N 653_E 1.042 0.75
487_V 651_G 1.036 0.75
201_Q 211_L 1.035 0.74
318_A 322_A 1.03 0.74
179_K 234_E 1.03 0.74
266_R 608_A 1.029 0.74
396_L 471_F 1.029 0.74
21_H 24_P 1.029 0.74
262_I 608_A 1.027 0.74
73_L 76_V 1.027 0.74
376_I 479_L 1.027 0.74
618_D 621_A 1.027 0.74
48_T 51_N 1.027 0.74
283_L 291_P 1.026 0.74
203_E 208_E 1.025 0.73
184_E 210_Y 1.025 0.73
521_H 524_T 1.023 0.73
247_G 254_D 1.021 0.73
139_L 281_K 1.019 0.73
599_F 602_I 1.016 0.73
277_N 291_P 1.015 0.72
39_R 42_A 1.011 0.72
142_I 149_Q 1.01 0.72
367_F 395_E 1.008 0.72
556_L 584_V 1.005 0.71
499_E 506_E 1.005 0.71
26_V 67_F 1.003 0.71
343_Q 347_S 1.002 0.71
184_E 192_E 1.001 0.71
361_K 520_G 1 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ka7A10.98971000.094Contact Map0.717
1y79110.98531000.127Contact Map0.705
2o36A10.95741000.134Contact Map0.67
2o3eA10.96031000.142Contact Map0.646
2qr4A20.80881000.51Contact Map0.579
3ahnA20.78821000.517Contact Map0.564
3sksA10.79261000.517Contact Map0.513
3ce2A10.82791000.519Contact Map0.569
3nxqA20.78971000.543Contact Map0.534
1r42A10.80151000.554Contact Map0.504
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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