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OPENSEQ.org
EFTU2 - Elongation factor Tu 2
UniProt: P0CE48 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11037
Length: 394 (391)
Sequences: 3775
Seq/Len: 9.65
EFTU2
Paralog alert: 0.35 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: CYSN EFTU1 EFTU2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
242_E 253_K 4.709 1.00
306_E 391_K 4.315 1.00
144_E 148_E 4.276 1.00
146_L 149_L 3.957 1.00
294_A 299_I 3.903 1.00
304_K 362_T 3.611 1.00
371_D 391_K 3.581 1.00
164_P 167_D 3.183 1.00
238_K 268_E 3.084 1.00
236_I 268_E 3.019 1.00
306_E 358_K 3.015 1.00
306_E 360_V 2.811 1.00
228_V 287_I 2.725 1.00
351_V 357_I 2.688 1.00
46_A 49_Q 2.644 1.00
304_K 360_V 2.622 1.00
134_F 188_K 2.548 1.00
211_F 237_I 2.536 1.00
34_T 38_K 2.485 1.00
138_C 172_R 2.457 1.00
211_F 232_V 2.438 1.00
232_V 269_G 2.422 1.00
148_E 151_E 2.421 1.00
135_L 154_V 2.399 1.00
194_G 198_S 2.368 1.00
234_R 370_D 2.261 1.00
33_T 68_V 2.252 1.00
244_E 296_P 2.216 1.00
237_I 269_G 2.187 1.00
232_V 275_V 2.183 1.00
185_W 188_K 2.15 1.00
309_V 359_M 2.065 1.00
45_R 52_N 1.99 1.00
215_I 228_V 1.985 1.00
34_T 44_A 1.971 1.00
237_I 277_V 1.958 1.00
258_G 265_L 1.948 1.00
38_K 186_E 1.913 1.00
177_K 180_E 1.904 1.00
151_E 155_R 1.895 1.00
238_K 241_E 1.883 1.00
241_E 295_K 1.868 1.00
52_N 66_S 1.865 1.00
120_I 154_V 1.834 1.00
255_T 280_R 1.832 1.00
186_E 190_L 1.798 1.00
305_F 363_L 1.77 1.00
42_G 45_R 1.76 1.00
252_Q 286_E 1.741 1.00
237_I 256_C 1.738 1.00
237_I 259_V 1.736 1.00
308_E 358_K 1.717 1.00
231_R 274_N 1.715 1.00
135_L 147_L 1.712 1.00
305_F 361_V 1.685 1.00
259_V 277_V 1.678 1.00
239_V 265_L 1.644 1.00
277_V 293_L 1.629 1.00
148_E 172_R 1.626 1.00
188_K 191_E 1.612 1.00
28_L 175_A 1.595 1.00
261_M 264_K 1.589 1.00
206_A 209_K 1.589 1.00
4_E 7_E 1.587 1.00
134_F 173_G 1.572 1.00
108_A 135_L 1.568 1.00
270_R 273_E 1.553 1.00
243_V 256_C 1.546 1.00
193_A 196_L 1.544 1.00
110_D 113_M 1.536 1.00
93_I 122_L 1.529 1.00
269_G 275_V 1.52 1.00
314_K 320_H 1.514 1.00
103_I 134_F 1.511 1.00
181_G 186_E 1.511 1.00
243_V 293_L 1.506 1.00
54_P 58_A 1.489 1.00
259_V 269_G 1.478 1.00
133_V 170_I 1.475 1.00
177_K 182_D 1.473 1.00
15_V 196_L 1.471 1.00
183_A 186_E 1.465 1.00
171_V 195_F 1.457 1.00
303_T 362_T 1.456 1.00
360_V 393_L 1.448 1.00
102_A 131_I 1.441 1.00
45_R 49_Q 1.431 1.00
72_T 193_A 1.417 0.99
369_M 389_V 1.404 0.99
183_A 187_A 1.402 0.99
187_A 191_E 1.402 0.99
283_K 286_E 1.36 0.99
236_I 270_R 1.335 0.99
187_A 190_L 1.332 0.99
109_T 140_M 1.322 0.99
48_D 57_K 1.318 0.99
345_P 348_V 1.309 0.99
331_F 361_V 1.305 0.99
52_N 64_N 1.304 0.99
325_K 343_E 1.293 0.99
10_K 71_D 1.293 0.99
239_V 259_V 1.29 0.99
191_E 194_G 1.282 0.99
18_I 123_G 1.279 0.99
43_A 49_Q 1.276 0.99
101_G 200_I 1.276 0.99
333_F 369_M 1.272 0.99
51_D 56_E 1.265 0.99
38_K 41_G 1.261 0.99
192_L 196_L 1.258 0.98
77_Y 196_L 1.255 0.98
308_E 390_A 1.248 0.98
244_E 253_K 1.235 0.98
246_V 294_A 1.232 0.98
107_A 112_P 1.227 0.98
44_A 47_F 1.226 0.98
212_L 370_D 1.223 0.98
73_P 194_G 1.21 0.98
92_M 96_A 1.21 0.98
303_T 366_P 1.207 0.98
56_E 60_G 1.207 0.98
257_T 280_R 1.203 0.98
333_F 367_I 1.202 0.98
184_E 187_A 1.198 0.98
182_D 185_W 1.198 0.98
352_M 355_D 1.194 0.98
105_V 134_F 1.186 0.98
57_K 64_N 1.182 0.98
261_M 266_L 1.175 0.97
343_E 346_E 1.17 0.97
245_I 254_S 1.168 0.97
239_V 267_D 1.166 0.97
13_V 200_I 1.163 0.97
343_E 360_V 1.158 0.97
51_D 57_K 1.147 0.97
16_G 99_M 1.146 0.97
307_S 359_M 1.143 0.97
104_L 116_T 1.143 0.97
51_D 59_R 1.138 0.97
341_T 362_T 1.132 0.97
309_V 385_G 1.126 0.96
4_E 43_A 1.121 0.96
154_V 170_I 1.117 0.96
254_S 283_K 1.115 0.96
13_V 202_E 1.111 0.96
243_V 254_S 1.11 0.96
333_F 336_T 1.106 0.96
51_D 55_E 1.103 0.96
149_L 153_E 1.097 0.96
117_R 157_L 1.092 0.95
133_V 158_L 1.092 0.95
55_E 59_R 1.084 0.95
152_M 156_E 1.084 0.95
195_F 198_S 1.083 0.95
64_N 91_N 1.077 0.95
28_L 134_F 1.074 0.95
43_A 47_F 1.066 0.95
51_D 60_G 1.063 0.95
146_L 150_V 1.06 0.94
130_Y 201_P 1.059 0.94
287_I 291_Q 1.058 0.94
104_L 154_V 1.057 0.94
240_G 259_V 1.056 0.94
32_I 193_A 1.053 0.94
221_I 227_V 1.049 0.94
74_T 194_G 1.046 0.94
336_T 365_H 1.044 0.94
340_G 363_L 1.039 0.94
177_K 185_W 1.038 0.94
328_R 364_I 1.037 0.94
256_C 259_V 1.035 0.93
242_E 255_T 1.034 0.93
213_L 232_V 1.033 0.93
26_T 30_A 1.033 0.93
20_H 23_H 1.028 0.93
284_R 291_Q 1.028 0.93
343_E 362_T 1.025 0.93
222_S 283_K 1.024 0.93
145_E 149_L 1.019 0.93
254_S 280_R 1.016 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3avxA111000.259Contact Map0.736
1d2eA40.97721000.267Contact Map0.78
2c78A10.99751000.269Contact Map0.757
1f60A10.9671000.274Contact Map0.697
3j2k710.97211000.279Contact Map0.041
3mcaA10.97211000.285Contact Map0.667
1r5bA10.96451000.286Contact Map0.732
1jnyA20.96191000.292Contact Map0.759
3izq110.97971000.298Contact Map0.61
3p26A20.97721000.301Contact Map0.763
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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