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OPENSEQ.org
EFTU1 - Elongation factor Tu 1
UniProt: P0CE47 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11036
Length: 394 (391)
Sequences: 3756
Seq/Len: 9.61
EFTU1
Paralog alert: 0.35 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: CYSN EFTU1 EFTU2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
242_E 253_K 4.607 1.00
144_E 148_E 4.31 1.00
306_E 391_K 4.24 1.00
146_L 149_L 3.974 1.00
294_A 299_I 3.907 1.00
304_K 362_T 3.621 1.00
371_D 391_K 3.592 1.00
164_P 167_D 3.131 1.00
238_K 268_E 3.085 1.00
236_I 268_E 3.06 1.00
306_E 358_K 3.025 1.00
306_E 360_V 2.795 1.00
228_V 287_I 2.685 1.00
304_K 360_V 2.655 1.00
211_F 237_I 2.593 1.00
34_T 38_K 2.592 1.00
351_V 357_I 2.565 1.00
46_A 49_Q 2.552 1.00
134_F 188_K 2.471 1.00
211_F 232_V 2.456 1.00
194_G 198_S 2.455 1.00
148_E 151_E 2.442 1.00
135_L 154_V 2.418 1.00
138_C 172_R 2.418 1.00
232_V 269_G 2.31 1.00
244_E 296_P 2.286 1.00
33_T 68_V 2.281 1.00
237_I 269_G 2.248 1.00
185_W 188_K 2.223 1.00
234_R 370_D 2.143 1.00
309_V 359_M 2.121 1.00
232_V 275_V 2.096 1.00
38_K 186_E 1.974 1.00
45_R 52_N 1.973 1.00
151_E 155_R 1.972 1.00
258_G 265_L 1.951 1.00
34_T 44_A 1.943 1.00
215_I 228_V 1.935 1.00
237_I 277_V 1.933 1.00
120_I 154_V 1.833 1.00
186_E 190_L 1.817 1.00
177_K 180_E 1.799 1.00
241_E 295_K 1.795 1.00
52_N 66_S 1.794 1.00
237_I 256_C 1.777 1.00
305_F 363_L 1.775 1.00
255_T 280_R 1.774 1.00
238_K 241_E 1.749 1.00
237_I 259_V 1.745 1.00
308_E 358_K 1.723 1.00
231_R 274_N 1.716 1.00
148_E 172_R 1.706 1.00
259_V 277_V 1.688 1.00
42_G 45_R 1.681 1.00
239_V 265_L 1.674 1.00
252_Q 286_E 1.669 1.00
305_F 361_V 1.656 1.00
134_F 173_G 1.649 1.00
277_V 293_L 1.644 1.00
108_A 135_L 1.63 1.00
261_M 264_K 1.614 1.00
28_L 175_A 1.596 1.00
206_A 209_K 1.593 1.00
188_K 191_E 1.573 1.00
314_K 320_H 1.567 1.00
183_A 186_E 1.561 1.00
110_D 113_M 1.552 1.00
135_L 147_L 1.536 1.00
93_I 122_L 1.529 1.00
15_V 196_L 1.514 1.00
193_A 196_L 1.512 1.00
72_T 193_A 1.509 1.00
45_R 49_Q 1.507 1.00
4_E 7_E 1.499 1.00
269_G 275_V 1.484 1.00
259_V 269_G 1.481 1.00
243_V 256_C 1.475 1.00
103_I 134_F 1.472 1.00
54_P 58_A 1.471 1.00
181_G 186_E 1.47 1.00
171_V 195_F 1.46 1.00
133_V 170_I 1.46 1.00
102_A 131_I 1.455 1.00
270_R 273_E 1.447 1.00
303_T 362_T 1.437 1.00
177_K 182_D 1.422 0.99
243_V 293_L 1.419 0.99
369_M 389_V 1.411 0.99
360_V 393_L 1.41 0.99
283_K 286_E 1.376 0.99
187_A 191_E 1.372 0.99
183_A 187_A 1.355 0.99
109_T 140_M 1.349 0.99
73_P 194_G 1.337 0.99
345_P 348_V 1.315 0.99
10_K 71_D 1.304 0.99
239_V 259_V 1.303 0.99
191_E 194_G 1.303 0.99
325_K 343_E 1.29 0.99
192_L 196_L 1.288 0.99
52_N 64_N 1.282 0.99
333_F 369_M 1.28 0.99
18_I 123_G 1.278 0.99
77_Y 196_L 1.275 0.99
331_F 361_V 1.27 0.99
51_D 56_E 1.269 0.99
38_K 41_G 1.269 0.99
236_I 270_R 1.265 0.99
244_E 253_K 1.259 0.98
101_G 200_I 1.258 0.98
187_A 190_L 1.251 0.98
343_E 346_E 1.246 0.98
303_T 366_P 1.238 0.98
308_E 390_A 1.236 0.98
105_V 134_F 1.234 0.98
44_A 47_F 1.231 0.98
246_V 294_A 1.23 0.98
107_A 112_P 1.223 0.98
56_E 60_G 1.221 0.98
182_D 185_W 1.215 0.98
43_A 49_Q 1.215 0.98
333_F 367_I 1.202 0.98
343_E 360_V 1.181 0.97
261_M 266_L 1.178 0.97
352_M 355_D 1.178 0.97
13_V 200_I 1.174 0.97
16_G 99_M 1.174 0.97
341_T 362_T 1.172 0.97
92_M 96_A 1.17 0.97
104_L 116_T 1.163 0.97
240_G 259_V 1.155 0.97
133_V 158_L 1.147 0.97
254_S 283_K 1.146 0.97
245_I 254_S 1.143 0.97
51_D 59_R 1.142 0.97
212_L 370_D 1.142 0.97
184_E 187_A 1.138 0.97
13_V 202_E 1.136 0.97
333_F 336_T 1.127 0.96
51_D 57_K 1.127 0.96
257_T 280_R 1.126 0.96
307_S 359_M 1.12 0.96
213_L 232_V 1.115 0.96
309_V 385_G 1.115 0.96
336_T 365_H 1.112 0.96
57_K 64_N 1.103 0.96
195_F 198_S 1.101 0.96
48_D 57_K 1.099 0.96
28_L 134_F 1.095 0.96
117_R 157_L 1.093 0.95
149_L 153_E 1.092 0.95
51_D 55_E 1.091 0.95
184_E 188_K 1.085 0.95
152_M 156_E 1.082 0.95
145_E 149_L 1.081 0.95
74_T 194_G 1.081 0.95
51_D 60_G 1.077 0.95
239_V 267_D 1.076 0.95
146_L 150_V 1.076 0.95
43_A 47_F 1.074 0.95
382_R 385_G 1.074 0.95
55_E 59_R 1.072 0.95
64_N 91_N 1.071 0.95
221_I 227_V 1.07 0.95
101_G 196_L 1.063 0.95
343_E 362_T 1.063 0.95
177_K 185_W 1.054 0.94
104_L 154_V 1.054 0.94
243_V 254_S 1.051 0.94
307_S 361_V 1.05 0.94
375_F 387_G 1.05 0.94
242_E 255_T 1.047 0.94
287_I 291_Q 1.046 0.94
32_I 193_A 1.043 0.94
130_Y 201_P 1.043 0.94
5_K 267_D 1.04 0.94
239_V 258_G 1.039 0.94
4_E 43_A 1.039 0.94
154_V 170_I 1.038 0.94
174_S 177_K 1.037 0.94
24_G 27_T 1.031 0.93
284_R 291_Q 1.024 0.93
256_C 259_V 1.024 0.93
378_R 383_T 1.021 0.93
222_S 283_K 1.02 0.93
328_R 364_I 1.02 0.93
20_H 23_H 1.019 0.93
340_G 363_L 1.018 0.93
74_T 198_S 1.017 0.93
186_E 189_I 1.014 0.93
79_H 161_Y 1.012 0.92
43_A 48_D 1.01 0.92
254_S 280_R 1.009 0.92
178_A 181_G 1.009 0.92
164_P 168_T 1.006 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3avxA111000.258Contact Map0.727
1d2eA40.97721000.266Contact Map0.769
2c78A10.99751000.268Contact Map0.746
1f60A10.9671000.272Contact Map0.685
3j2k710.97211000.279Contact Map0.04
3mcaA10.97211000.284Contact Map0.66
1r5bA10.96451000.288Contact Map0.729
1jnyA20.96191000.29Contact Map0.75
3izq110.97971000.299Contact Map0.613
3p26A20.97721000.302Contact Map0.759
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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