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OPENSEQ.org
URAA - Uracil permease
UniProt: P0AGM7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12129
Length: 429 (409)
Sequences: 2118
Seq/Len: 5.18
URAA
Paralog alert: 0.73 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: RUTG UACT URAA XANP XANQ YBBY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
164_T 195_L 4.759 1.00
168_V 191_V 4.467 1.00
95_I 278_G 4.07 1.00
131_V 395_A 3.574 1.00
212_W 321_K 3.291 1.00
205_T 209_N 3.279 1.00
169_T 188_G 2.998 1.00
48_L 317_S 2.8 1.00
172_G 187_I 2.774 1.00
194_A 198_A 2.662 1.00
100_L 232_L 2.512 1.00
99_V 275_V 2.481 1.00
204_T 207_I 2.413 1.00
161_I 196_S 2.401 1.00
164_T 168_V 2.357 1.00
161_I 201_I 2.354 1.00
144_A 162_S 2.33 1.00
166_L 340_L 2.29 1.00
51_G 314_I 2.215 1.00
160_I 164_T 2.214 1.00
89_V 222_R 2.205 1.00
92_G 223_F 2.202 1.00
372_I 399_G 2.168 1.00
210_A 321_K 2.164 1.00
168_V 172_G 2.149 1.00
21_S 308_G 2.119 1.00
25_L 312_F 2.114 1.00
375_I 398_V 2.113 1.00
102_C 275_V 2.085 1.00
49_F 280_F 2.073 1.00
169_T 337_V 2.066 1.00
246_L 266_S 2.023 1.00
105_S 268_F 2.017 1.00
88_E 222_R 1.989 1.00
17_T 308_G 1.96 1.00
206_P 328_M 1.953 1.00
207_I 325_A 1.944 1.00
53_G 273_S 1.927 1.00
190_L 194_A 1.925 1.00
311_I 315_L 1.891 1.00
102_C 268_F 1.884 1.00
193_Y 202_V 1.838 1.00
164_T 191_V 1.829 1.00
256_D 259_R 1.806 1.00
104_V 239_I 1.768 1.00
205_T 208_I 1.751 1.00
401_G 405_I 1.747 1.00
96_M 228_I 1.726 1.00
99_V 103_L 1.696 1.00
262_G 265_R 1.686 1.00
166_L 371_V 1.677 0.99
157_K 201_I 1.663 0.99
18_I 312_F 1.661 0.99
64_K 260_D 1.658 0.99
194_A 197_F 1.653 0.99
210_A 324_A 1.634 0.99
192_G 333_V 1.634 0.99
160_I 199_M 1.613 0.99
161_I 199_M 1.569 0.99
375_I 394_L 1.536 0.99
208_I 211_H 1.533 0.99
86_G 89_V 1.528 0.99
55_L 307_G 1.528 0.99
98_G 275_V 1.525 0.99
119_L 404_L 1.519 0.99
168_V 195_L 1.508 0.99
79_V 90_A 1.504 0.99
368_L 402_L 1.501 0.99
55_L 314_I 1.501 0.99
156_S 160_I 1.496 0.99
134_L 346_G 1.488 0.99
98_G 274_T 1.48 0.98
180_L 187_I 1.469 0.98
176_F 180_L 1.46 0.98
55_L 310_A 1.449 0.98
6_I 10_E 1.424 0.98
364_Q 368_L 1.419 0.98
25_L 309_A 1.417 0.98
196_S 200_G 1.414 0.98
24_H 291_N 1.387 0.97
143_M 162_S 1.386 0.97
102_C 271_G 1.376 0.97
206_P 209_N 1.376 0.97
242_H 266_S 1.369 0.97
50_N 68_Y 1.369 0.97
300_V 305_V 1.365 0.97
364_Q 407_K 1.358 0.97
7_G 10_E 1.353 0.97
80_L 83_L 1.35 0.97
172_G 176_F 1.345 0.97
193_Y 328_M 1.339 0.97
9_S 255_K 1.328 0.96
121_P 403_S 1.317 0.96
360_Y 369_T 1.315 0.96
195_L 198_A 1.311 0.96
11_R 304_W 1.302 0.96
58_L 307_G 1.291 0.96
28_M 32_T 1.274 0.95
197_F 204_T 1.273 0.95
94_F 278_G 1.27 0.95
70_G 288_Y 1.269 0.95
187_I 191_V 1.259 0.95
171_L 175_L 1.258 0.95
130_A 373_L 1.253 0.94
207_I 210_A 1.252 0.94
197_F 202_V 1.233 0.94
48_L 280_F 1.224 0.94
99_V 102_C 1.214 0.93
95_I 221_P 1.208 0.93
81_L 84_P 1.207 0.93
224_E 227_A 1.204 0.93
157_K 199_M 1.199 0.93
39_F 79_V 1.198 0.93
58_L 306_I 1.198 0.93
176_F 181_A 1.194 0.92
66_P 93_G 1.189 0.92
89_V 224_E 1.188 0.92
123_A 369_T 1.187 0.92
245_H 289_G 1.182 0.92
52_I 314_I 1.18 0.92
225_W 228_I 1.178 0.92
164_T 199_M 1.17 0.91
198_A 201_I 1.167 0.91
179_F 183_I 1.166 0.91
6_I 12_P 1.162 0.91
147_L 383_N 1.158 0.91
140_A 162_S 1.157 0.91
223_F 228_I 1.152 0.91
145_G 153_T 1.152 0.91
372_I 398_V 1.151 0.91
397_I 401_G 1.145 0.90
242_H 246_L 1.14 0.90
14_L 18_I 1.135 0.90
11_R 17_T 1.121 0.89
322_L 325_A 1.12 0.89
250_A 258_L 1.119 0.89
95_I 275_V 1.117 0.89
31_A 290_E 1.112 0.88
106_F 110_K 1.106 0.88
52_I 56_L 1.104 0.88
166_L 170_V 1.099 0.88
140_A 165_T 1.098 0.88
72_S 238_V 1.096 0.87
46_V 283_T 1.079 0.86
295_M 301_Y 1.077 0.86
31_A 342_Y 1.075 0.86
53_G 269_A 1.074 0.86
167_A 171_L 1.07 0.86
343_G 366_L 1.07 0.86
90_A 93_G 1.069 0.86
129_V 245_H 1.066 0.85
171_L 405_I 1.062 0.85
162_S 272_L 1.061 0.85
147_L 154_P 1.061 0.85
82_L 93_G 1.06 0.85
92_G 96_M 1.059 0.85
28_M 68_Y 1.057 0.85
69_L 287_T 1.057 0.85
8_V 12_P 1.054 0.85
27_A 294_V 1.053 0.84
168_V 387_A 1.052 0.84
245_H 292_I 1.05 0.84
373_L 377_V 1.047 0.84
214_A 320_G 1.042 0.84
167_A 170_V 1.038 0.83
103_L 107_I 1.035 0.83
193_Y 197_F 1.034 0.83
190_L 325_A 1.034 0.83
88_E 219_Y 1.022 0.82
277_S 285_N 1.02 0.82
20_L 289_G 1.02 0.82
383_N 388_E 1.012 0.81
24_H 27_A 1.009 0.81
128_I 166_L 1.008 0.81
8_V 302_S 1.007 0.81
168_V 188_G 1.004 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A111000.338Contact Map0.58
2gfpA20.431224.30.973Contact Map0.129
1pw4A10.491821.40.974Contact Map0.299
3o7qA10.496518.30.975Contact Map0.278
2jlnA10.883415.90.975Contact Map0.197
2xutA30.46396.10.98Contact Map0.147
2cfqA10.44765.20.98Contact Map0.262
2i68A20.27743.30.982Contact Map0
2kluA10.11422.60.983Contact Map0.663
4ltoA40.25872.60.983Contact Map0.548
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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