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OPENSEQ.org
XANQ - Xanthine permease XanQ
UniProt: P67444 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13065
Length: 466 (444)
Sequences: 2136
Seq/Len: 4.81
XANQ
Paralog alert: 0.73 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: RUTG UACT URAA XANP XANQ YBBY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
193_L 224_A 4.649 1.00
197_V 220_V 4.596 1.00
126_F 312_S 3.68 1.00
157_M 435_G 3.568 1.00
241_L 355_M 3.318 1.00
170_F 191_G 3.266 1.00
234_S 238_N 3.26 1.00
198_V 217_G 3.204 1.00
66_I 351_G 2.994 1.00
223_I 227_C 2.858 1.00
130_F 309_V 2.711 1.00
201_F 216_I 2.707 1.00
47_G 57_T 2.701 1.00
190_V 225_S 2.618 1.00
190_V 230_M 2.58 1.00
53_S 56_T 2.576 1.00
233_F 236_M 2.491 1.00
131_L 263_G 2.478 1.00
193_L 197_V 2.408 1.00
195_L 374_L 2.404 1.00
403_S 439_A 2.368 1.00
189_G 193_L 2.362 1.00
69_G 348_V 2.324 1.00
219_C 223_I 2.267 1.00
239_L 355_M 2.254 1.00
28_A 342_T 2.244 1.00
236_M 359_F 2.204 1.00
406_L 438_T 2.185 1.00
67_A 314_V 2.129 1.00
32_L 346_M 2.126 1.00
133_V 309_V 2.108 1.00
248_F 313_A 2.094 1.00
123_G 254_F 2.094 1.00
198_V 371_A 2.062 1.00
136_S 302_L 2.024 1.00
197_V 201_F 2.022 1.00
235_S 362_T 2.02 1.00
277_I 300_G 2 1.00
71_G 307_V 1.982 1.00
120_S 253_S 1.938 1.00
133_V 302_L 1.918 1.00
119_S 253_S 1.901 1.00
193_L 220_V 1.892 1.00
125_S 312_S 1.857 1.00
24_A 342_T 1.846 1.00
135_S 270_V 1.844 1.00
223_I 226_L 1.834 1.00
39_M 42_P 1.832 1.00
345_V 349_I 1.825 1.00
395_R 447_P 1.823 1.00
186_E 230_M 1.818 1.00
441_L 445_I 1.816 1.00
237_R 240_P 1.798 1.00
25_L 346_M 1.745 1.00
195_L 402_T 1.738 1.00
222_Y 231_V 1.713 1.00
171_G 182_F 1.702 0.99
234_S 237_R 1.691 0.99
292_E 295_S 1.684 0.99
189_G 228_L 1.632 0.99
173_G 183_G 1.597 0.99
221_G 367_V 1.596 0.99
73_W 348_V 1.585 0.99
160_L 380_A 1.566 0.99
127_V 259_F 1.563 0.99
406_L 434_A 1.559 0.99
130_F 134_G 1.554 0.99
73_W 341_R 1.545 0.99
145_V 444_I 1.545 0.99
73_W 344_A 1.523 0.99
129_A 309_V 1.52 0.99
282_M 389_T 1.519 0.99
190_V 228_L 1.503 0.98
239_L 358_G 1.497 0.98
32_L 343_I 1.497 0.98
205_R 209_L 1.488 0.98
129_A 308_S 1.484 0.98
209_L 216_I 1.481 0.98
399_I 442_L 1.481 0.98
31_H 325_N 1.473 0.98
193_L 228_L 1.465 0.98
201_F 205_R 1.449 0.98
197_V 224_A 1.441 0.98
185_Y 189_G 1.431 0.98
222_Y 362_T 1.389 0.97
13_F 17_D 1.385 0.97
133_V 305_G 1.377 0.97
219_C 359_F 1.377 0.97
334_V 339_V 1.365 0.97
147_T 443_N 1.36 0.96
225_S 229_G 1.351 0.96
226_L 233_F 1.342 0.96
186_E 228_L 1.342 0.96
78_R 85_G 1.339 0.96
205_R 210_R 1.331 0.96
224_A 227_C 1.323 0.96
255_S 258_Q 1.32 0.96
101_I 104_G 1.317 0.96
273_A 300_G 1.31 0.95
216_I 220_V 1.298 0.95
100_M 121_L 1.297 0.95
296_R 299_G 1.296 0.95
18_R 338_Y 1.296 0.95
169_D 365_S 1.295 0.95
276_D 323_A 1.282 0.95
21_F 25_L 1.281 0.95
14_E 17_D 1.279 0.95
13_F 19_P 1.269 0.94
66_I 314_V 1.264 0.94
437_L 441_L 1.259 0.94
16_E 286_R 1.259 0.94
235_S 238_N 1.248 0.94
200_G 204_C 1.247 0.94
236_M 239_L 1.241 0.93
90_Q 321_T 1.236 0.93
149_T 400_V 1.236 0.93
50_L 104_G 1.211 0.92
91_S 322_F 1.211 0.92
134_G 138_I 1.206 0.92
387_I 390_N 1.2 0.92
256_F 259_F 1.189 0.91
403_S 438_T 1.189 0.91
77_N 341_R 1.188 0.91
166_G 191_G 1.188 0.91
192_L 196_I 1.177 0.91
227_C 230_M 1.167 0.90
40_V 43_A 1.164 0.90
156_L 404_L 1.161 0.90
31_H 35_I 1.159 0.90
191_G 306_L 1.158 0.90
281_A 288_I 1.156 0.90
224_A 228_L 1.156 0.90
385_R 389_T 1.146 0.89
18_R 24_A 1.143 0.89
38_P 324_Q 1.142 0.89
121_L 124_V 1.141 0.89
70_I 74_L 1.137 0.89
139_L 301_V 1.135 0.88
136_S 298_K 1.132 0.88
226_L 231_V 1.131 0.88
155_V 276_D 1.129 0.88
166_G 194_V 1.128 0.88
415_E 418_K 1.126 0.88
176_A 181_T 1.123 0.88
276_D 326_N 1.116 0.87
34_A 328_V 1.113 0.87
273_A 277_I 1.108 0.87
247_P 315_G 1.104 0.87
329_I 335_A 1.103 0.86
42_P 94_F 1.101 0.86
120_S 255_S 1.098 0.86
46_V 100_M 1.097 0.86
82_V 306_L 1.096 0.86
35_I 39_M 1.094 0.86
208_L 212_G 1.092 0.86
35_I 89_I 1.091 0.86
243_T 354_P 1.084 0.85
133_V 306_L 1.081 0.85
95_S 375_M 1.081 0.85
38_P 376_F 1.079 0.85
277_I 304_D 1.055 0.83
70_I 348_V 1.055 0.83
93_N 269_S 1.049 0.82
35_I 325_N 1.049 0.82
200_G 445_I 1.048 0.82
66_I 348_V 1.048 0.82
186_E 190_V 1.045 0.82
71_G 303_A 1.045 0.82
15_L 336_S 1.04 0.82
237_R 441_L 1.04 0.82
31_H 34_A 1.039 0.82
64_A 317_L 1.036 0.81
15_L 19_P 1.032 0.81
25_L 237_R 1.032 0.81
273_A 304_D 1.03 0.81
130_F 133_V 1.025 0.80
272_E 320_T 1.022 0.80
355_M 358_G 1.022 0.80
356_I 359_F 1.021 0.80
239_L 354_P 1.021 0.80
222_Y 226_L 1.018 0.80
377_S 397_T 1.015 0.80
404_L 408_L 1.011 0.79
132_V 269_S 1.007 0.79
27_G 323_A 1.007 0.79
47_G 60_L 1.006 0.79
311_A 319_L 1 0.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A10.8971000.454Contact Map0.574
1pw4A10.8884430.971Contact Map0.085
3o7qA10.407731.20.973Contact Map0.422
4ikvA10.909928.40.974Contact Map0.243
2jlnA10.873418.70.976Contact Map0.216
2cfqA10.8455140.977Contact Map0.212
4j05A20.952812.10.978Contact Map0.172
3wdoA10.83058.30.979Contact Map0.22
4apsA20.90137.80.98Contact Map0.217
1rlzA10.135260.981Contact Map0.258
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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