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OPENSEQ.org
NUON - NADH-quinone oxidoreductase subunit N
UniProt: P0AFF0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12093
Length: 485 (470)
Sequences: 6207
Seq/Len: 13.21
NUON
Paralog alert: 0.84 [within 20: 0.59] - ratio of genomes with paralogs
Cluster includes: HYCC HYFB HYFD HYFF NUOL NUOM NUON
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_D 256_R 4.869 1.00
118_L 131_G 4.547 1.00
185_S 188_A 3.794 1.00
339_G 379_M 3.436 1.00
158_K 229_D 3.402 1.00
332_G 390_L 3.291 1.00
183_D 188_A 3.235 1.00
293_N 357_D 3.064 1.00
77_T 121_N 2.865 1.00
84_S 113_A 2.862 1.00
80_V 120_A 2.737 1.00
377_T 429_A 2.533 1.00
311_V 414_V 2.518 1.00
144_G 156_S 2.481 1.00
356_A 361_S 2.479 1.00
285_N 304_S 2.422 1.00
292_T 360_F 2.394 1.00
329_Y 394_G 2.366 1.00
125_L 257_L 2.329 1.00
297_L 359_L 2.286 1.00
125_L 189_L 2.279 1.00
358_S 361_S 2.258 1.00
20_T 44_G 2.232 1.00
220_L 310_L 2.207 1.00
281_I 417_G 2.196 1.00
231_Y 246_S 2.194 1.00
231_Y 239_S 2.168 1.00
289_L 423_Y 2.149 1.00
91_A 105_F 2.12 1.00
301_S 424_Y 2.102 1.00
373_A 434_L 2.064 1.00
173_G 213_G 2.025 1.00
313_L 326_V 2.004 1.00
77_T 117_I 1.995 1.00
380_M 425_Y 1.974 1.00
122_A 127_S 1.942 1.00
369_R 372_L 1.919 1.00
335_F 463_L 1.914 1.00
399_L 414_V 1.909 1.00
183_D 189_L 1.895 1.00
115_G 134_L 1.894 1.00
359_L 432_L 1.884 1.00
221_V 279_A 1.884 1.00
255_M 313_L 1.85 1.00
381_L 386_I 1.828 1.00
211_I 215_G 1.819 1.00
277_A 314_I 1.808 1.00
173_G 209_L 1.803 1.00
219_S 227_T 1.799 1.00
427_R 431_S 1.787 1.00
462_L 466_V 1.786 1.00
73_A 251_F 1.771 1.00
373_A 429_A 1.765 1.00
271_V 275_I 1.757 1.00
470_W 473_P 1.751 1.00
325_A 401_V 1.729 1.00
154_E 158_K 1.726 1.00
402_G 411_V 1.722 1.00
180_Q 206_G 1.713 1.00
366_F 373_A 1.706 1.00
282_I 417_G 1.706 1.00
123_N 187_V 1.662 1.00
328_V 394_G 1.654 1.00
378_V 461_A 1.641 1.00
292_T 358_S 1.641 1.00
215_G 220_L 1.64 1.00
124_H 184_L 1.632 1.00
75_L 331_A 1.606 1.00
312_A 398_V 1.582 1.00
376_M 433_Y 1.575 1.00
412_G 416_V 1.569 1.00
70_D 73_A 1.569 1.00
81_L 117_I 1.565 1.00
294_I 428_V 1.555 1.00
211_I 273_L 1.545 1.00
128_L 186_F 1.545 1.00
220_L 276_I 1.528 1.00
315_A 402_G 1.516 1.00
467_L 474_L 1.512 1.00
173_G 210_M 1.509 1.00
371_I 458_L 1.506 1.00
69_V 121_N 1.501 1.00
79_L 334_L 1.495 1.00
298_L 344_V 1.492 1.00
124_H 185_S 1.489 1.00
333_Y 337_S 1.484 1.00
188_A 191_K 1.473 1.00
459_I 463_L 1.461 1.00
162_L 225_L 1.458 1.00
236_A 295_K 1.437 1.00
376_M 380_M 1.432 1.00
126_A 184_L 1.423 1.00
188_A 192_N 1.414 1.00
151_R 232_Q 1.407 0.99
246_S 302_S 1.404 0.99
472_Q 476_S 1.401 0.99
291_Q 296_R 1.379 0.99
208_G 212_V 1.368 0.99
66_L 123_N 1.368 0.99
275_I 279_A 1.362 0.99
142_L 238_V 1.361 0.99
376_M 428_V 1.341 0.99
331_A 474_L 1.329 0.99
155_A 233_G 1.327 0.99
83_A 334_L 1.326 0.99
170_L 213_G 1.317 0.99
312_A 322_S 1.312 0.99
388_M 469_V 1.306 0.99
110_L 114_L 1.304 0.99
228_P 300_Y 1.302 0.99
348_S 357_D 1.301 0.99
228_P 291_Q 1.298 0.99
108_L 141_G 1.286 0.99
129_F 171_L 1.281 0.99
305_H 424_Y 1.281 0.99
380_M 429_A 1.28 0.99
177_V 189_L 1.279 0.99
451_S 454_G 1.277 0.99
125_L 174_M 1.277 0.99
466_V 470_W 1.27 0.99
229_D 296_R 1.258 0.99
283_F 287_M 1.257 0.99
170_L 174_M 1.255 0.99
82_L 463_L 1.246 0.98
175_A 179_A 1.238 0.98
173_G 206_G 1.238 0.98
176_L 206_G 1.238 0.98
277_A 310_L 1.235 0.98
68_R 71_G 1.234 0.98
458_L 462_L 1.23 0.98
88_C 106_Y 1.229 0.98
93_P 453_G 1.225 0.98
315_A 322_S 1.224 0.98
140_F 163_S 1.217 0.98
227_T 231_Y 1.215 0.98
304_S 421_G 1.208 0.98
274_A 410_L 1.205 0.98
216_F 223_F 1.199 0.98
359_L 431_S 1.196 0.98
336_S 382_S 1.195 0.98
268_A 271_V 1.195 0.98
309_L 326_V 1.19 0.98
285_N 417_G 1.186 0.98
69_V 74_M 1.181 0.98
101_N 104_E 1.175 0.98
255_M 326_V 1.161 0.97
374_A 433_Y 1.16 0.97
452_A 455_I 1.159 0.97
379_M 464_V 1.155 0.97
278_F 413_A 1.153 0.97
15_L 19_L 1.152 0.97
73_A 256_R 1.151 0.97
21_V 111_I 1.151 0.97
116_G 245_A 1.147 0.97
285_N 301_S 1.143 0.97
231_Y 243_A 1.143 0.97
383_L 425_Y 1.143 0.97
247_K 252_G 1.139 0.97
429_A 434_L 1.138 0.97
400_A 404_Q 1.138 0.97
277_A 311_V 1.137 0.97
215_G 276_I 1.134 0.97
377_T 433_Y 1.129 0.97
332_G 394_G 1.128 0.97
169_F 212_V 1.125 0.97
232_Q 296_R 1.125 0.97
68_R 123_N 1.121 0.97
88_C 109_V 1.118 0.96
231_Y 302_S 1.115 0.96
329_Y 332_G 1.115 0.96
408_W 412_G 1.11 0.96
178_Y 181_S 1.11 0.96
282_I 413_A 1.109 0.96
274_A 314_I 1.107 0.96
374_A 378_V 1.105 0.96
463_L 467_L 1.103 0.96
143_V 230_V 1.101 0.96
75_L 327_G 1.1 0.96
178_Y 184_L 1.098 0.96
73_A 77_T 1.095 0.96
112_A 116_G 1.092 0.96
249_A 252_G 1.092 0.96
83_A 338_L 1.09 0.96
183_D 186_F 1.089 0.96
98_Y 146_A 1.072 0.95
336_S 391_G 1.071 0.95
161_I 165_A 1.069 0.95
128_L 252_G 1.069 0.95
378_V 465_L 1.067 0.95
308_Y 398_V 1.065 0.95
324_E 479_R 1.064 0.95
76_Y 330_L 1.063 0.95
172_F 209_L 1.063 0.95
373_A 377_T 1.061 0.95
371_I 375_V 1.054 0.95
279_A 409_W 1.054 0.95
181_S 189_L 1.052 0.95
333_Y 341_F 1.047 0.94
67_M 121_N 1.045 0.94
186_F 261_A 1.041 0.94
322_S 401_V 1.039 0.94
14_L 77_T 1.034 0.94
456_V 459_I 1.032 0.94
115_G 138_P 1.029 0.94
375_V 461_A 1.027 0.94
228_P 303_I 1.025 0.93
304_S 424_Y 1.025 0.93
249_A 253_V 1.024 0.93
116_G 135_I 1.018 0.93
66_L 185_S 1.017 0.93
243_A 302_S 1.012 0.93
292_T 301_S 1.01 0.93
274_A 311_V 1.008 0.93
285_N 424_Y 1.006 0.93
344_V 362_Y 1.003 0.93
255_M 323_M 1.001 0.92
86_A 456_V 1 0.92
363_R 438_E 1 0.92
85_L 89_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rkoN20.99791000.131Contact Map0.65
3rkoM20.94641000.214Contact Map0.706
4he8M20.92371000.223Contact Map0.673
4he8L20.94431000.229Contact Map0.731
3rkoL20.94851000.247Contact Map0.721
4he8N20.87841000.26Contact Map0.668
4he8K20.183545.90.965Contact Map0.685
3rkoK20.197926.40.969Contact Map0.456
3arcX20.07844.10.979Contact Map0.351
1nkzA30.10933.40.98Contact Map0.293
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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