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YIGB - Flavin mononucleotide phosphatase YigB
UniProt: P0ADP0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11202
Length: 238 (228)
Sequences: 10411
Seq/Len: 45.66

YIGB
Paralog alert: 0.91 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: GPH PGMB YFBT YIEH YIGB YIHX YJJG YNIC YQAB YRFG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
11_S 182_E 4.336 1.00
187_G 193_D 3.367 1.00
197_A 204_A 3.177 1.00
171_L 175_K 3.099 1.00
142_E 147_G 2.875 1.00
198_I 225_H 2.774 1.00
12_A 178_V 2.688 1.00
173_A 183_I 2.681 1.00
161_R 165_F 2.68 1.00
123_K 149_Y 2.601 1.00
130_P 151_E 2.557 1.00
171_L 174_E 2.404 1.00
119_H 123_K 2.389 1.00
229_S 233_S 2.275 1.00
126_A 151_E 2.205 1.00
10_I 203_Q 2.183 1.00
184_L 205_C 2.178 1.00
139_A 158_P 2.175 1.00
194_V 204_A 2.138 1.00
134_I 168_M 2.113 1.00
195_G 199_R 2.022 1.00
118_T 231_L 1.988 1.00
203_Q 225_H 1.937 1.00
179_P 182_E 1.931 1.00
14_T 134_I 1.911 1.00
161_R 167_D 1.906 1.00
131_L 150_F 1.892 1.00
132_V 152_F 1.869 1.00
173_A 202_M 1.856 1.00
15_F 131_L 1.789 1.00
13_L 129_W 1.788 1.00
173_A 180_I 1.765 1.00
13_L 186_V 1.759 1.00
126_A 149_Y 1.736 1.00
12_A 176_L 1.731 1.00
38_F 100_A 1.727 1.00
14_T 172_A 1.715 1.00
152_F 175_K 1.663 1.00
205_C 228_I 1.643 1.00
208_R 229_S 1.635 1.00
124_Q 235_T 1.621 1.00
99_H 103_I 1.582 1.00
178_V 183_I 1.573 1.00
185_H 197_A 1.565 1.00
13_L 125_L 1.559 1.00
230_R 233_S 1.515 1.00
34_E 104_N 1.508 1.00
154_L 172_A 1.495 1.00
17_L 22_Y 1.49 1.00
132_V 176_L 1.475 1.00
117_Q 120_D 1.464 1.00
183_I 202_M 1.426 1.00
114_V 146_L 1.398 0.99
121_T 235_T 1.392 0.99
154_L 175_K 1.378 0.99
100_A 104_N 1.372 0.99
226_L 237_L 1.364 0.99
20_T 186_V 1.356 0.99
14_T 185_H 1.34 0.99
124_Q 128_K 1.325 0.99
205_C 226_L 1.323 0.99
78_R 81_E 1.322 0.99
124_Q 127_K 1.316 0.99
21_L 118_T 1.315 0.99
14_T 183_I 1.297 0.99
139_A 155_R 1.278 0.99
39_V 100_A 1.276 0.99
169_Y 187_G 1.274 0.99
135_T 155_R 1.273 0.99
214_L 218_W 1.267 0.99
38_F 104_N 1.249 0.99
34_E 38_F 1.248 0.99
121_T 231_L 1.236 0.98
125_L 129_W 1.232 0.98
123_K 127_K 1.231 0.98
228_I 234_L 1.23 0.98
120_D 232_A 1.225 0.98
169_Y 202_M 1.19 0.98
18_D 24_N 1.189 0.98
208_R 227_E 1.188 0.98
194_V 206_W 1.187 0.98
73_T 77_F 1.183 0.98
115_P 209_P 1.182 0.98
104_N 107_K 1.179 0.98
169_Y 185_H 1.173 0.98
30_R 34_E 1.152 0.97
198_I 204_A 1.145 0.97
10_I 184_L 1.144 0.97
93_E 96_A 1.123 0.97
194_V 224_P 1.119 0.96
35_A 39_V 1.109 0.96
145_G 148_D 1.108 0.96
114_V 119_H 1.105 0.96
120_D 123_K 1.102 0.96
134_I 172_A 1.09 0.96
117_Q 230_R 1.082 0.96
34_E 37_T 1.08 0.95
96_A 100_A 1.077 0.95
12_A 130_P 1.075 0.95
122_L 149_Y 1.058 0.95
185_H 202_M 1.054 0.95
167_D 171_L 1.053 0.95
117_Q 121_T 1.051 0.94
185_H 193_D 1.048 0.94
17_L 133_A 1.039 0.94
152_F 176_L 1.039 0.94
133_A 150_F 1.038 0.94
169_Y 196_G 1.034 0.94
160_G 167_D 1.024 0.93
123_K 148_D 1.019 0.93
104_N 108_W 1.019 0.93
95_S 99_H 1.018 0.93
20_T 193_D 1.018 0.93
192_T 195_G 1.015 0.93
170_F 180_I 1.012 0.93
22_Y 144_F 1.011 0.93
81_E 85_L 1.01 0.93
166_S 170_F 1.01 0.93
30_R 33_R 1.005 0.93
30_R 111_R 1.001 0.92
190_L 195_G 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3vayA20.94961000.304Contact Map0.825
4eekA10.89921000.311Contact Map0.752
3s6jA60.88661000.319Contact Map0.702
3ed5A10.93281000.321Contact Map0.764
2om6A20.92441000.326Contact Map0.841
1swvA20.92861000.328Contact Map0.817
3qnmA10.9371000.329Contact Map0.848
3qxgA20.8951000.332Contact Map0.838
2hdoA10.85291000.338Contact Map0.826
3sd7A10.89081000.339Contact Map0.793

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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