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YIHX - Alpha-D-glucose-1-phosphate phosphatase YihX
UniProt: P0A8Y3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11850
Length: 199 (188)
Sequences: 11746
Seq/Len: 62.48

YIHX
Paralog alert: 0.93 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: GPH PGMB YFBT YIEH YIGB YIHX YJJG YNIC YQAB YRFG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
1_M 160_D 3.866 1.00
149_H 153_A 2.97 1.00
165_D 170_N 2.922 1.00
174_A 181_S 2.899 1.00
119_E 125_R 2.877 1.00
139_M 143_E 2.655 1.00
94_H 127_A 2.596 1.00
2_L 156_F 2.53 1.00
111_R 115_T 2.516 1.00
102_R 129_D 2.504 1.00
149_H 152_Q 2.461 1.00
90_I 94_H 2.453 1.00
151_L 161_T 2.413 1.00
111_R 136_D 2.26 1.00
97_R 129_D 2.226 1.00
106_L 146_I 2.149 1.00
151_L 179_I 2.117 1.00
171_I 181_S 2.113 1.00
104_V 130_H 2.106 1.00
107_S 114_T 2.043 1.00
172_E 176_Q 2.043 1.00
162_V 182_I 2.034 1.00
130_H 153_A 2.028 1.00
157_S 160_D 1.932 1.00
5_F 103_V 1.921 1.00
139_M 145_R 1.881 1.00
4_I 106_L 1.869 1.00
97_R 127_A 1.823 1.00
3_Y 101_H 1.819 1.00
151_L 158_P 1.751 1.00
163_F 174_A 1.696 1.00
168_A 172_E 1.689 1.00
4_I 150_V 1.681 1.00
103_V 128_A 1.675 1.00
95_K 99_Q 1.659 1.00
104_V 154_E 1.653 1.00
26_L 77_G 1.612 1.00
2_L 154_E 1.582 1.00
3_Y 164_F 1.564 1.00
156_F 161_T 1.53 1.00
3_Y 96_L 1.517 1.00
132_Y 150_V 1.454 1.00
7_L 12_V 1.412 1.00
132_Y 153_A 1.401 0.99
7_L 105_V 1.397 0.99
115_T 125_R 1.389 0.99
161_T 179_I 1.349 0.99
10_V 164_F 1.348 0.99
95_K 98_E 1.316 0.99
144_A 148_Q 1.28 0.99
88_E 91_A 1.276 0.99
4_I 163_F 1.253 0.99
4_I 161_T 1.25 0.99
22_A 26_L 1.247 0.99
2_L 161_T 1.244 0.98
171_I 183_L 1.238 0.98
169_D 172_E 1.237 0.98
114_T 133_L 1.226 0.98
11_I 89_V 1.219 0.98
147_Y 163_F 1.203 0.98
53_S 56_A 1.183 0.98
175_N 181_S 1.171 0.98
138_G 145_R 1.161 0.97
147_Y 165_D 1.16 0.97
163_F 179_I 1.15 0.97
85_L 124_I 1.148 0.97
7_L 114_T 1.133 0.97
25_D 31_L 1.126 0.97
56_A 59_E 1.122 0.97
97_R 103_V 1.115 0.96
105_V 128_A 1.113 0.96
145_R 149_H 1.111 0.96
96_L 101_H 1.11 0.96
111_R 133_L 1.11 0.96
85_L 90_I 1.11 0.96
8_G 14_I 1.105 0.96
106_L 150_V 1.101 0.96
164_F 182_I 1.097 0.96
173_G 177_L 1.083 0.96
91_A 94_H 1.079 0.95
23_W 27_T 1.067 0.95
22_A 25_D 1.066 0.95
172_E 175_N 1.064 0.95
70_S 73_Q 1.063 0.95
121_Y 124_I 1.062 0.95
107_S 133_L 1.06 0.95
94_H 98_E 1.055 0.95
147_Y 179_I 1.054 0.95
115_T 119_E 1.053 0.95
116_F 120_E 1.051 0.94
73_Q 77_G 1.05 0.94
86_R 186_D 1.048 0.94
123_E 126_D 1.039 0.94
130_H 154_E 1.024 0.93
2_L 102_R 1.023 0.93
4_I 179_I 1.021 0.93
162_V 180_T 1.012 0.93
19_V 23_W 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2b0cA111000.215Contact Map0.836
4jb3A10.98491000.218Contact Map0.754
2i6xA10.98491000.23Contact Map0.728
4dccA10.97491000.247Contact Map0.759
3i28A111000.295Contact Map0.81
3cnhA20.97491000.303Contact Map0.805
4eekA10.93971000.306Contact Map0.761
3ed5A10.98991000.319Contact Map0.774
3nasA20.919699.90.323Contact Map0.778
3iruA20.989999.90.323Contact Map0.683

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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