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OPENSEQ.org
EDD - Phosphogluconate dehydratase
UniProt: P0ADF6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10257
Length: 603 (537)
Sequences: 2282
Seq/Len: 4.25
EDD
Paralog alert: 0.49 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: EDD ILVD YAGF YJHG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
445_E 545_R 4.807 1.00
282_I 287_V 4.242 1.00
285_K 367_H 4.198 1.00
545_R 556_L 4.154 1.00
537_K 566_E 4.018 1.00
537_K 562_L 3.671 1.00
246_F 344_I 3.538 1.00
445_E 556_L 3.53 1.00
445_E 543_I 3.377 1.00
288_V 367_H 3.239 1.00
561_E 564_A 3.161 1.00
547_N 550_T 3.119 1.00
147_G 269_T 3.042 1.00
203_D 206_A 3.038 1.00
430_A 553_L 3.021 1.00
361_L 368_E 2.996 1.00
538_V 555_L 2.948 1.00
543_I 556_L 2.9 1.00
468_R 503_K 2.887 1.00
174_V 265_V 2.848 1.00
68_I 147_G 2.805 1.00
368_E 379_S 2.759 1.00
70_I 95_L 2.735 1.00
71_I 148_A 2.682 1.00
321_D 424_S 2.669 1.00
545_R 554_T 2.618 1.00
539_R 561_E 2.554 1.00
174_V 264_Q 2.535 1.00
374_A 381_Y 2.518 1.00
324_S 328_D 2.508 1.00
285_K 369_D 2.457 1.00
558_D 561_E 2.44 1.00
449_V 540_D 2.439 1.00
557_V 562_L 2.434 1.00
293_A 357_V 2.432 1.00
162_T 239_M 2.417 1.00
447_P 543_I 2.413 1.00
449_V 470_C 2.392 1.00
282_I 286_V 2.38 1.00
234_V 240_Q 2.372 1.00
170_H 280_K 2.344 1.00
166_L 282_I 2.325 1.00
539_R 568_H 2.289 1.00
295_L 326_L 2.242 1.00
276_M 280_K 2.216 1.00
260_A 263_R 2.186 1.00
426_N 554_T 2.161 1.00
239_M 282_I 2.153 1.00
264_Q 267_R 2.141 1.00
370_V 378_L 2.128 1.00
451_F 465_L 2.045 1.00
162_T 310_M 2.041 1.00
408_A 412_Q 2.035 1.00
427_L 538_V 2.032 1.00
538_V 544_I 2.011 1.00
68_I 269_T 2.01 1.00
559_E 563_A 2.002 1.00
563_A 567_P 1.995 1.00
452_E 456_D 1.991 1.00
288_V 325_D 1.966 1.00
291_I 323_F 1.958 1.00
564_A 567_P 1.945 1.00
480_K 531_D 1.938 1.00
284_E 288_V 1.936 1.00
292_V 326_L 1.928 1.00
459_P 463_A 1.917 1.00
197_Y 204_R 1.916 1.00
534_L 562_L 1.881 1.00
325_D 329_V 1.877 1.00
562_L 566_E 1.87 1.00
284_E 325_D 1.858 1.00
267_R 270_G 1.857 1.00
451_F 460_A 1.847 1.00
150_F 173_A 1.841 1.00
284_E 317_Q 1.836 1.00
376_F 380_R 1.835 1.00
292_V 330_V 1.82 1.00
453_S 456_D 1.806 1.00
409_S 412_Q 1.803 1.00
460_A 466_L 1.803 1.00
421_K 551_G 1.801 1.00
194_R 515_A 1.786 1.00
100_A 266_T 1.781 1.00
357_V 378_L 1.772 1.00
292_V 329_V 1.766 0.99
289_N 370_V 1.759 0.99
182_A 250_D 1.758 0.99
72_T 104_V 1.757 0.99
165_A 173_A 1.756 0.99
170_H 276_M 1.749 0.99
202_V 206_A 1.747 0.99
94_A 97_E 1.74 0.99
456_D 459_P 1.729 0.99
319_N 322_D 1.72 0.99
253_L 348_Q 1.707 0.99
554_T 559_E 1.684 0.99
328_D 417_H 1.678 0.99
166_L 314_A 1.675 0.99
450_V 540_D 1.662 0.99
97_E 263_R 1.661 0.99
324_S 551_G 1.654 0.99
538_V 557_V 1.647 0.99
197_Y 202_V 1.643 0.99
473_V 555_L 1.628 0.99
236_F 293_A 1.625 0.99
507_V 525_V 1.624 0.99
229_T 299_G 1.614 0.99
209_E 213_A 1.602 0.99
449_V 467_D 1.58 0.99
78_L 110_A 1.561 0.98
147_G 265_V 1.545 0.98
363_A 410_F 1.537 0.98
312_R 596_Q 1.535 0.98
255_D 259_A 1.532 0.98
443_V 549_Q 1.523 0.98
447_P 470_C 1.52 0.98
450_V 538_V 1.507 0.98
86_H 255_D 1.5 0.98
176_V 261_A 1.497 0.98
452_E 476_H 1.489 0.98
537_K 557_V 1.48 0.98
377_G 380_R 1.478 0.98
376_F 381_Y 1.472 0.98
70_I 148_A 1.469 0.97
68_I 95_L 1.468 0.97
284_E 322_D 1.467 0.97
342_A 405_N 1.465 0.97
85_E 89_E 1.454 0.97
449_V 460_A 1.447 0.97
272_G 276_M 1.446 0.97
359_E 362_K 1.438 0.97
427_L 534_L 1.436 0.97
443_V 547_N 1.429 0.97
563_A 566_E 1.419 0.97
422_V 431_V 1.418 0.97
321_D 325_D 1.415 0.97
170_H 279_G 1.415 0.97
444_I 447_P 1.403 0.96
557_V 561_E 1.399 0.96
448_A 538_V 1.392 0.96
93_K 96_H 1.386 0.96
281_M 286_V 1.384 0.96
208_L 212_A 1.383 0.96
94_A 262_A 1.378 0.96
196_L 201_K 1.377 0.96
592_S 596_Q 1.375 0.96
166_L 239_M 1.368 0.96
136_A 164_A 1.363 0.96
88_P 151_L 1.353 0.95
186_P 206_A 1.342 0.95
534_L 555_L 1.337 0.95
86_H 89_E 1.333 0.95
111_M 142_H 1.322 0.95
322_D 325_D 1.319 0.94
90_I 259_A 1.319 0.94
317_Q 596_Q 1.314 0.94
555_L 562_L 1.301 0.94
183_S 345_N 1.297 0.94
361_L 379_S 1.292 0.94
287_V 310_M 1.289 0.94
268_M 275_W 1.282 0.93
96_H 102_G 1.282 0.93
95_L 100_A 1.274 0.93
76_D 92_R 1.266 0.93
347_F 356_L 1.261 0.93
438_P 502_F 1.261 0.93
560_A 564_A 1.249 0.92
392_L 398_A 1.246 0.92
282_I 314_A 1.241 0.92
426_N 559_E 1.241 0.92
404_S 412_Q 1.234 0.91
452_E 475_R 1.23 0.91
335_R 341_P 1.211 0.90
470_C 540_D 1.208 0.90
271_N 275_W 1.205 0.90
182_A 251_S 1.203 0.90
256_A 259_A 1.2 0.90
304_T 308_V 1.194 0.90
477_Q 485_P 1.188 0.89
67_N 103_Q 1.185 0.89
162_T 234_V 1.184 0.89
535_L 538_V 1.184 0.89
443_V 545_R 1.176 0.89
77_M 145_F 1.169 0.88
123_E 485_P 1.166 0.88
236_F 357_V 1.164 0.88
89_E 93_K 1.164 0.88
449_V 465_L 1.151 0.87
455_H 485_P 1.147 0.87
264_Q 271_N 1.147 0.87
341_P 405_N 1.142 0.87
522_A 546_V 1.132 0.86
242_P 381_Y 1.131 0.86
449_V 466_L 1.13 0.86
294_L 303_H 1.128 0.86
450_V 555_L 1.128 0.86
291_I 318_I 1.128 0.86
536_A 569_I 1.125 0.85
62_S 65_R 1.125 0.85
473_V 544_I 1.12 0.85
240_Q 244_S 1.12 0.85
558_D 564_A 1.12 0.85
526_T 595_E 1.112 0.85
426_N 555_L 1.11 0.84
587_L 591_L 1.105 0.84
421_K 549_Q 1.104 0.84
95_L 262_A 1.104 0.84
451_F 540_D 1.104 0.84
593_G 596_Q 1.104 0.84
275_W 371_N 1.103 0.84
571_D 575_S 1.101 0.84
280_K 371_N 1.09 0.83
174_V 373_V 1.086 0.83
191_V 210_S 1.081 0.82
342_A 414_F 1.08 0.82
229_T 303_H 1.073 0.82
285_K 288_V 1.071 0.81
185_L 190_K 1.061 0.81
427_L 475_R 1.06 0.80
149_L 262_A 1.059 0.80
307_L 318_I 1.056 0.80
456_D 465_L 1.055 0.80
448_A 544_I 1.053 0.80
443_V 550_T 1.046 0.79
564_A 568_H 1.044 0.79
450_V 473_V 1.041 0.79
534_L 559_E 1.04 0.79
84_Y 153_V 1.04 0.79
187_N 206_A 1.037 0.78
531_D 595_E 1.036 0.78
63_M 101_V 1.035 0.78
476_H 536_A 1.029 0.78
473_V 538_V 1.029 0.78
259_A 263_R 1.029 0.78
71_I 139_G 1.027 0.77
244_S 257_L 1.016 0.76
361_L 366_L 1.012 0.76
93_K 259_A 1.008 0.76
451_F 466_L 1.006 0.75
74_Y 85_E 1.006 0.75
68_I 265_V 1 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gp4A211000.035Contact Map0.611
1zymA20.364854.20.985Contact Map0.41
1q5xA30.228952.30.985Contact Map0.342
2pcnA10.230549.90.985Contact Map0.336
2is8A30.233846.90.985Contact Map0.427
3c8oA20.228941.10.986Contact Map0.349
4lhbA30.258735.80.986Contact Map0.362
1jljA30.26228.20.987Contact Map0.516
1j3lA60.233827.60.987Contact Map0.332
1mkzA20.248827.40.987Contact Map0.497
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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