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OPENSEQ.org
ILVD - Dihydroxy-acid dehydratase
UniProt: P05791 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10496
Length: 616 (591)
Sequences: 2307
Seq/Len: 3.90
ILVD
Paralog alert: 0.49 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: EDD ILVD YAGF YJHG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
449_T 548_A 4.577 1.00
540_L 569_R 4.416 1.00
260_A 265_F 4.152 1.00
540_L 565_L 3.886 1.00
431_E 537_S 3.796 1.00
263_A 346_N 3.596 1.00
266_E 346_N 3.396 1.00
548_A 559_Q 3.256 1.00
115_A 243_T 3.238 1.00
541_I 558_L 3.173 1.00
449_T 559_Q 3.117 1.00
255_L 258_N 3.095 1.00
137_N 258_N 3.067 1.00
37_I 115_A 3.041 1.00
449_T 546_L 2.977 1.00
220_S 323_M 2.89 1.00
472_A 507_A 2.742 1.00
141_I 239_I 2.741 1.00
434_C 556_I 2.738 1.00
550_D 553_N 2.707 1.00
271_L 336_L 2.7 1.00
302_D 306_R 2.678 1.00
130_L 213_L 2.675 1.00
353_L 360_T 2.607 1.00
340_D 347_R 2.603 1.00
347_R 358_P 2.573 1.00
432_N 604_D 2.563 1.00
134_L 260_A 2.507 1.00
213_L 260_A 2.505 1.00
260_A 264_A 2.45 1.00
177_S 180_Q 2.448 1.00
548_A 557_Q 2.44 1.00
453_K 543_D 2.436 1.00
137_N 257_R 2.432 1.00
546_L 559_Q 2.389 1.00
23_R 186_R 2.387 1.00
263_A 348_D 2.363 1.00
429_F 541_I 2.359 1.00
542_E 564_E 2.326 1.00
453_K 474_D 2.324 1.00
269_M 301_I 2.323 1.00
541_I 547_I 2.25 1.00
560_V 565_L 2.238 1.00
541_I 560_V 2.235 1.00
37_I 243_T 2.227 1.00
564_E 567_A 2.223 1.00
565_L 569_R 2.219 1.00
41_N 73_E 2.218 1.00
428_N 557_Q 2.213 1.00
451_P 546_L 2.189 1.00
561_S 564_E 2.156 1.00
273_I 304_L 2.134 1.00
349_V 357_L 2.132 1.00
39_V 64_I 2.128 1.00
23_R 29_D 2.089 1.00
227_D 327_H 2.033 1.00
171_G 176_V 2.015 1.00
299_S 426_Y 2.012 1.00
208_T 214_S 1.958 1.00
448_F 451_P 1.946 1.00
336_L 357_L 1.929 1.00
238_R 241_E 1.924 1.00
484_K 534_S 1.893 1.00
130_L 288_A 1.891 1.00
410_R 414_H 1.888 1.00
203_S 277_G 1.886 1.00
165_V 519_G 1.881 1.00
118_C 140_V 1.874 1.00
302_D 554_R 1.874 1.00
270_T 308_V 1.858 1.00
464_A 470_V 1.852 1.00
270_T 307_K 1.845 1.00
141_I 238_R 1.827 1.00
40_V 116_M 1.825 1.00
455_Y 469_K 1.809 0.99
423_A 554_R 1.798 0.99
149_E 224_T 1.788 0.99
456_E 480_Y 1.782 0.99
241_E 244_K 1.775 0.99
456_E 460_D 1.774 0.99
297_T 300_D 1.769 0.99
133_S 140_V 1.74 0.99
47_V 78_A 1.739 0.99
562_D 566_A 1.737 0.99
69_G 240_V 1.725 0.99
270_T 304_L 1.71 0.99
457_S 460_D 1.697 0.99
355_L 359_Q 1.696 0.99
262_K 266_E 1.694 0.99
266_E 303_K 1.692 0.99
171_G 178_D 1.652 0.99
170_Q 175_K 1.651 0.99
267_N 349_V 1.648 0.99
63_Q 236_G 1.635 0.99
282_V 286_L 1.624 0.99
234_N 237_K 1.622 0.99
306_R 419_D 1.599 0.98
210_A 271_L 1.598 0.98
356_T 359_Q 1.598 0.98
134_L 213_L 1.587 0.98
303_K 307_K 1.586 0.98
143_V 235_A 1.581 0.98
567_A 570_E 1.568 0.98
7_A 11_H 1.566 0.98
115_A 239_I 1.562 0.98
540_L 560_V 1.557 0.98
134_L 292_A 1.554 0.98
542_E 579_A 1.547 0.98
262_K 303_K 1.544 0.98
355_L 360_T 1.534 0.98
242_L 254_A 1.52 0.98
79_V 110_A 1.509 0.98
29_D 186_R 1.507 0.98
459_D 490_Q 1.506 0.98
137_N 255_L 1.505 0.97
511_I 528_V 1.504 0.97
37_I 64_I 1.495 0.97
259_I 264_A 1.492 0.97
150_A 324_E 1.476 0.97
66_A 237_K 1.472 0.97
537_S 565_L 1.455 0.97
117_V 236_G 1.454 0.97
176_V 180_Q 1.451 0.97
262_K 300_D 1.447 0.97
65_E 71_A 1.445 0.97
566_A 570_E 1.43 0.96
428_N 562_D 1.43 0.96
468_G 502_M 1.43 0.96
27_M 72_K 1.423 0.96
454_V 541_I 1.42 0.96
36_I 72_K 1.418 0.96
500_K 505_G 1.412 0.96
31_D 34_K 1.407 0.96
580_W 583_K 1.402 0.96
455_Y 464_A 1.401 0.96
245_R 254_A 1.398 0.96
64_I 69_G 1.395 0.96
557_Q 562_D 1.388 0.95
326_V 335_I 1.383 0.95
447_K 550_D 1.382 0.95
423_A 552_P 1.382 0.95
45_Q 61_A 1.381 0.95
91_L 490_Q 1.381 0.95
566_A 569_R 1.38 0.95
456_E 479_R 1.37 0.95
560_V 569_R 1.361 0.95
560_V 564_E 1.353 0.95
132_A 136_L 1.348 0.94
451_P 474_D 1.347 0.94
108_V 116_M 1.343 0.94
260_A 292_A 1.332 0.94
38_A 108_V 1.329 0.94
9_T 22_W 1.32 0.94
310_Q 417_S 1.311 0.93
19_R 185_E 1.31 0.93
210_A 336_L 1.307 0.93
63_Q 66_A 1.305 0.93
144_S 218_N 1.304 0.93
460_D 463_E 1.298 0.93
218_N 231_L 1.297 0.93
453_K 464_A 1.288 0.92
29_D 182_D 1.285 0.92
476_V 499_L 1.284 0.92
262_K 295_D 1.28 0.92
542_E 571_A 1.28 0.92
463_E 467_G 1.276 0.92
456_E 542_E 1.272 0.92
55_D 229_K 1.269 0.92
300_D 303_K 1.269 0.92
454_V 558_L 1.268 0.92
452_A 541_I 1.267 0.92
163_D 166_D 1.26 0.91
477_V 558_L 1.26 0.91
7_A 10_T 1.259 0.91
39_V 116_M 1.259 0.91
265_F 288_A 1.255 0.91
46_F 113_A 1.251 0.91
62_E 65_E 1.245 0.91
38_A 116_M 1.241 0.90
601_T 605_K 1.239 0.90
290_Q 605_K 1.226 0.90
358_P 361_L 1.224 0.90
161_K 166_D 1.223 0.90
141_I 352_V 1.218 0.89
214_S 218_N 1.217 0.89
596_Y 600_A 1.216 0.89
22_W 25_T 1.212 0.89
442_D 506_K 1.211 0.89
538_I 541_I 1.21 0.89
336_L 361_L 1.207 0.89
130_L 208_T 1.203 0.89
447_K 548_A 1.203 0.89
149_E 225_H 1.202 0.89
424_V 435_I 1.202 0.89
481_E 490_Q 1.199 0.88
299_S 303_K 1.199 0.88
57_G 119_I 1.198 0.88
452_A 547_I 1.197 0.88
429_F 479_R 1.196 0.88
43_F 54_R 1.186 0.88
24_A 48_P 1.185 0.88
340_D 358_P 1.183 0.87
60_V 117_V 1.179 0.87
27_M 70_V 1.175 0.87
453_K 470_V 1.174 0.87
474_D 543_D 1.172 0.87
183_Q 187_S 1.171 0.87
453_K 471_V 1.168 0.87
32_F 70_V 1.163 0.86
266_E 348_D 1.155 0.86
558_L 565_L 1.147 0.85
23_R 32_F 1.135 0.84
59_L 233_L 1.132 0.84
432_N 602_S 1.126 0.84
569_R 580_W 1.123 0.83
361_L 364_Y 1.119 0.83
436_V 551_I 1.117 0.83
540_L 580_W 1.116 0.83
203_S 281_T 1.115 0.83
429_F 537_S 1.114 0.83
269_M 296_F 1.112 0.83
338_E 341_R 1.109 0.82
411_S 414_H 1.107 0.82
285_L 296_F 1.098 0.82
141_I 242_L 1.095 0.81
428_N 558_L 1.095 0.81
480_Y 539_G 1.092 0.81
182_D 186_R 1.089 0.81
357_L 360_T 1.089 0.81
592_A 609_R 1.088 0.81
58_K 62_E 1.087 0.81
134_L 264_A 1.085 0.81
238_R 245_R 1.082 0.80
54_R 58_K 1.074 0.80
161_K 165_V 1.068 0.79
379_R 382_P 1.064 0.79
120_S 126_T 1.058 0.78
66_A 233_L 1.058 0.78
17_G 168_M 1.058 0.78
216_P 360_T 1.056 0.78
64_I 236_G 1.056 0.78
454_V 543_D 1.053 0.78
77_I 103_S 1.047 0.77
118_C 133_S 1.044 0.77
131_M 291_E 1.04 0.76
205_N 219_G 1.037 0.76
132_A 138_I 1.037 0.76
162_L 165_V 1.035 0.76
591_F 594_R 1.035 0.76
378_F 382_P 1.029 0.75
118_C 142_F 1.028 0.75
191_T 226_A 1.026 0.75
272_D 281_T 1.025 0.75
144_S 228_R 1.024 0.75
264_A 294_I 1.023 0.75
36_I 70_V 1.023 0.75
337_G 363_Q 1.022 0.75
221_L 225_H 1.021 0.75
470_V 474_D 1.016 0.74
34_K 70_V 1.013 0.74
465_I 495_P 1.013 0.74
263_A 266_E 1.009 0.73
535_G 580_W 1.009 0.73
302_D 305_S 1.005 0.73
254_A 350_K 1.003 0.73
31_D 237_K 1.001 0.73
537_S 558_L 1.001 0.73
232_F 235_A 1 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gp4A20.91881000.113Contact Map0.61
3rfqA30.2484630.983Contact Map0.45
2pcnA10.227360.60.984Contact Map0.322
4lhbA30.246859.30.984Contact Map0.269
1j3lA60.233857.30.984Contact Map0.288
1c41A100.245154.30.984Contact Map0.527
2is8A30.2256530.984Contact Map0.432
3c8oA20.227350.80.984Contact Map0.325
1di6A10.26350.80.984Contact Map0.38
1nxjA30.263500.985Contact Map0.307
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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