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OPENSEQ.org
HTRB - Lipid A biosynthesis lauroyl acyltransferase
UniProt: P0ACV0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10464
Length: 306 (300)
Sequences: 1942
Seq/Len: 6.47
HTRB
Paralog alert: 0.59 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: DDG HTRB MSBB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
271_A 275_K 3.487 1.00
71_S 74_E 3.277 1.00
81_K 286_E 3.022 1.00
111_I 251_Q 2.965 1.00
60_H 79_V 2.929 1.00
63_L 75_R 2.739 1.00
70_M 74_E 2.703 1.00
109_E 251_Q 2.693 1.00
69_E 282_M 2.662 1.00
115_H 256_P 2.564 1.00
111_I 253_I 2.557 1.00
212_P 271_A 2.545 1.00
46_K 84_E 2.544 1.00
214_F 278_E 2.454 1.00
41_G 87_G 2.437 1.00
60_H 76_R 2.436 1.00
188_A 193_E 2.375 1.00
244_K 251_Q 2.349 1.00
221_T 274_N 2.317 1.00
112_G 115_H 2.261 1.00
117_R 121_A 2.255 1.00
67_F 70_M 2.104 1.00
33_P 36_V 2.098 1.00
113_M 117_R 2.096 1.00
275_K 278_E 1.996 1.00
61_R 64_E 1.976 1.00
150_I 193_E 1.963 1.00
64_E 72_E 1.959 1.00
58_I 293_R 1.942 1.00
49_L 56_A 1.933 1.00
70_M 78_M 1.892 1.00
65_L 216_V 1.87 1.00
155_P 178_D 1.863 1.00
237_V 254_M 1.798 1.00
238_P 255_L 1.755 1.00
70_M 75_R 1.75 1.00
77_K 81_K 1.737 1.00
119_V 237_V 1.679 1.00
267_E 271_A 1.674 1.00
265_D 268_T 1.669 1.00
212_P 217_E 1.665 1.00
64_E 75_R 1.66 1.00
59_V 79_V 1.652 1.00
118_D 122_Q 1.638 1.00
242_R 284_A 1.614 1.00
154_R 157_D 1.598 1.00
277_V 281_I 1.586 1.00
124_R 235_C 1.585 1.00
242_R 251_Q 1.567 0.99
211_V 271_A 1.558 0.99
238_P 257_P 1.526 0.99
8_S 11_L 1.516 0.99
41_G 45_G 1.486 0.99
74_E 77_K 1.48 0.99
255_L 276_V 1.475 0.99
209_V 270_A 1.472 0.99
92_E 243_R 1.437 0.99
290_W 294_R 1.435 0.99
37_I 91_M 1.435 0.99
152_V 185_M 1.424 0.99
115_H 118_D 1.422 0.99
255_L 279_K 1.415 0.99
43_G 47_L 1.401 0.99
49_L 80_V 1.389 0.98
114_E 118_D 1.385 0.98
131_I 277_V 1.377 0.98
135_T 288_Y 1.375 0.98
163_W 167_W 1.374 0.98
74_E 78_M 1.37 0.98
212_P 275_K 1.367 0.98
276_V 279_K 1.365 0.98
59_V 82_N 1.336 0.98
127_L 234_A 1.332 0.98
242_R 253_I 1.332 0.98
27_W 31_Q 1.332 0.98
126_I 235_C 1.327 0.98
66_C 295_F 1.319 0.98
214_F 282_M 1.315 0.98
201_H 292_H 1.282 0.97
42_C 88_M 1.28 0.97
55_R 292_H 1.271 0.97
57_K 61_R 1.266 0.97
211_V 274_N 1.261 0.97
186_I 190_K 1.256 0.96
210_F 297_T 1.252 0.96
278_E 282_M 1.245 0.96
199_P 225_T 1.24 0.96
226_W 270_A 1.24 0.96
42_C 84_E 1.234 0.96
78_M 286_E 1.231 0.96
105_A 145_M 1.222 0.96
175_S 193_E 1.218 0.96
201_H 290_W 1.21 0.95
128_L 239_F 1.202 0.95
115_H 237_V 1.202 0.95
35_P 39_R 1.2 0.95
137_E 196_W 1.2 0.95
292_H 296_K 1.199 0.95
166_T 170_L 1.199 0.95
63_L 70_M 1.194 0.95
125_G 189_L 1.162 0.94
39_R 42_C 1.158 0.94
210_F 217_E 1.158 0.94
46_K 80_V 1.152 0.94
85_S 88_M 1.14 0.93
243_R 287_Q 1.14 0.93
47_L 51_F 1.136 0.93
156_N 162_D 1.134 0.93
288_Y 295_F 1.118 0.92
100_P 103_R 1.115 0.92
298_R 302_V 1.115 0.92
136_L 198_A 1.114 0.92
87_G 90_L 1.111 0.92
238_P 276_V 1.11 0.92
185_M 195_V 1.108 0.92
39_R 43_G 1.108 0.92
153_Y 176_M 1.104 0.91
216_V 298_R 1.104 0.91
201_H 294_R 1.099 0.91
201_H 289_M 1.096 0.91
272_W 275_K 1.093 0.91
56_A 60_H 1.084 0.90
53_K 56_A 1.07 0.90
183_K 186_I 1.068 0.90
202_D 297_T 1.063 0.89
276_V 280_C 1.055 0.89
60_H 75_R 1.049 0.88
99_W 103_R 1.047 0.88
103_R 107_W 1.045 0.88
210_F 220_A 1.044 0.88
275_K 279_K 1.043 0.88
218_Q 302_V 1.04 0.88
126_I 194_V 1.036 0.88
38_Y 88_M 1.035 0.88
59_V 291_L 1.035 0.88
156_N 165_Q 1.033 0.87
162_D 166_T 1.024 0.87
116_I 128_L 1.02 0.87
129_V 199_P 1.017 0.86
272_W 276_V 1.017 0.86
31_Q 36_V 1.012 0.86
56_A 83_F 1.009 0.86
131_I 199_P 1.005 0.85
124_R 233_G 1.004 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1iuqA10.9314970.9Contact Map0.521
4gr6A20.19937.40.967Contact Map0.546
2i3sB30.10466.10.968Contact Map0.159
1p3qQ20.17655.50.969Contact Map0.781
4gr2A20.1833.10.972Contact Map0.291
4gycB10.29082.90.973Contact Map0
3ka1A20.16672.90.973Contact Map0.479
3iz6M10.31052.50.973Contact Map0.241
1s28A40.24842.50.973Contact Map0.065
2wwbB10.10782.50.973Contact Map0.221
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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