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MSBB - Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase
UniProt: P24205 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10614
Length: 323 (303)
Sequences: 1767
Seq/Len: 5.83
MSBB
Paralog alert: 0.58 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: DDG HTRB MSBB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
78_S 81_E 3.471 1.00
279_R 283_E 3.215 1.00
88_E 294_E 3.121 1.00
118_Q 259_T 2.883 1.00
70_L 82_R 2.873 1.00
77_R 81_E 2.871 1.00
53_R 91_A 2.828 1.00
67_L 86_V 2.802 1.00
76_E 290_G 2.657 1.00
67_L 83_E 2.647 1.00
48_L 94_P 2.581 1.00
122_I 264_P 2.535 1.00
118_Q 261_Q 2.443 1.00
223_F 286_E 2.361 1.00
116_D 259_T 2.338 1.00
229_T 282_N 2.331 1.00
124_E 128_R 2.329 1.00
221_D 279_R 2.326 1.00
119_G 122_I 2.314 1.00
40_P 43_F 2.222 1.00
197_S 202_Y 2.169 1.00
77_R 85_I 2.141 1.00
74_F 77_R 2.088 1.00
68_I 71_S 2.068 1.00
71_S 79_E 2.065 1.00
120_L 124_E 2.044 1.00
65_R 301_K 2.043 1.00
221_D 226_Y 2.006 1.00
283_E 286_E 1.94 1.00
252_D 259_T 1.911 1.00
84_A 88_E 1.866 1.00
245_V 262_V 1.859 1.00
77_R 82_R 1.826 1.00
56_G 63_R 1.819 1.00
66_A 86_V 1.785 1.00
126_M 245_V 1.767 1.00
163_N 186_A 1.74 1.00
271_E 277_I 1.726 1.00
246_P 263_R 1.724 1.00
285_V 289_V 1.714 1.00
158_A 202_Y 1.711 1.00
71_S 82_R 1.684 1.00
48_L 52_G 1.678 1.00
131_E 243_R 1.667 1.00
125_E 129_N 1.548 0.99
273_D 276_T 1.54 0.99
162_H 165_G 1.539 0.99
99_M 251_Y 1.478 0.99
81_E 85_I 1.475 0.99
250_I 292_R 1.475 0.99
72_L 225_T 1.465 0.99
81_E 84_A 1.455 0.99
171_Y 175_T 1.439 0.98
298_W 302_L 1.438 0.98
246_P 265_P 1.432 0.98
15_D 18_F 1.43 0.98
220_V 279_R 1.426 0.98
44_R 98_A 1.418 0.98
34_A 38_L 1.412 0.98
122_I 125_E 1.398 0.98
250_I 259_T 1.395 0.98
133_V 243_R 1.383 0.98
134_I 242_A 1.383 0.98
56_G 87_D 1.381 0.98
210_Q 300_L 1.381 0.98
208_P 233_I 1.376 0.98
138_P 285_V 1.37 0.98
73_C 303_L 1.364 0.98
221_D 283_E 1.348 0.97
161_F 184_L 1.344 0.97
50_R 54_F 1.322 0.97
49_A 91_A 1.314 0.97
49_A 95_Q 1.31 0.97
174_N 178_R 1.303 0.97
300_L 304_K 1.301 0.97
223_F 290_G 1.291 0.96
135_F 247_L 1.28 0.96
142_A 296_Y 1.28 0.96
183_R 202_Y 1.279 0.96
275_H 279_R 1.258 0.96
66_A 89_M 1.253 0.96
121_E 125_E 1.242 0.95
218_E 278_A 1.238 0.95
286_E 290_G 1.228 0.95
210_Q 298_W 1.226 0.95
62_S 300_L 1.218 0.95
64_R 68_I 1.213 0.94
263_R 284_E 1.207 0.94
85_I 294_E 1.201 0.94
250_I 261_Q 1.194 0.94
144_D 205_Y 1.183 0.93
210_Q 302_L 1.183 0.93
63_R 67_L 1.177 0.93
43_F 46_P 1.175 0.93
53_R 87_D 1.175 0.93
225_T 306_R 1.169 0.93
54_F 58_L 1.168 0.93
125_E 128_R 1.167 0.93
263_R 287_I 1.163 0.93
132_K 198_V 1.161 0.93
210_Q 297_T 1.158 0.92
220_V 282_N 1.154 0.92
219_F 305_T 1.152 0.92
42_K 46_P 1.151 0.92
195_I 199_R 1.149 0.92
211_D 305_T 1.141 0.92
143_V 207_L 1.137 0.92
306_R 310_E 1.12 0.91
219_F 226_Y 1.117 0.91
284_E 287_I 1.115 0.90
160_M 194_F 1.113 0.90
122_I 245_V 1.109 0.90
272_A 277_I 1.103 0.90
234_G 278_A 1.102 0.90
92_T 95_Q 1.101 0.90
13_E 17_S 1.1 0.90
46_P 49_A 1.099 0.90
46_P 50_R 1.081 0.89
134_I 236_L 1.079 0.88
192_K 195_I 1.079 0.88
67_L 82_R 1.078 0.88
194_F 204_G 1.077 0.88
164_Q 173_W 1.075 0.88
108_P 112_Q 1.068 0.88
164_Q 170_D 1.066 0.88
308_P 311_I 1.06 0.87
284_E 288_F 1.053 0.87
138_P 208_P 1.05 0.87
110_K 114_R 1.045 0.86
75_P 82_R 1.042 0.86
298_W 304_K 1.038 0.86
79_E 83_E 1.032 0.85
94_P 97_M 1.031 0.85
70_L 77_R 1.028 0.85
66_A 299_I 1.028 0.85
45_D 95_Q 1.028 0.85
136_L 208_P 1.021 0.84
161_F 170_D 1.02 0.84
296_Y 303_L 1.02 0.84
137_V 205_Y 1.015 0.84
107_G 110_K 1.013 0.84
106_R 110_K 1.009 0.84
197_S 204_G 1.006 0.83
166_N 300_L 1.003 0.83
121_E 124_E 1.002 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1iuqA10.900997.10.912Contact Map0.52
1p3qQ20.16726.50.972Contact Map0.754
2i3sB30.09916.10.972Contact Map0.139
4gr6A20.21365.90.972Contact Map0.426
4gn0A40.30965.50.973Contact Map0.202
1dmuA10.25395.30.973Contact Map0.438
2e7pA40.35294.80.973Contact Map0.546
1jbeA10.34984.10.974Contact Map0.363
3izca10.334440.975Contact Map0
3ka1A20.17653.60.975Contact Map0.429
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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