May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
WZXE - Protein WzxE
UniProt: P0AAA7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11486
Length: 416 (412)
Sequences: 13828
Seq/Len: 33.56
WZXE
Paralog alert: 0.91 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: DINF MDTK MURJ RFBX WZXC WZXE YEEO YGHQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_N 75_Q 4.337 1.00
215_G 219_K 3.649 1.00
285_E 288_D 3.56 1.00
41_A 255_Q 3.419 1.00
144_D 147_G 3.415 1.00
101_A 104_P 3.387 1.00
128_G 184_A 3.058 1.00
314_L 317_F 2.839 1.00
319_I 330_M 2.782 1.00
117_G 173_E 2.608 1.00
67_A 281_S 2.553 1.00
62_V 83_S 2.451 1.00
315_R 335_A 2.325 1.00
211_N 215_G 2.293 1.00
386_G 389_G 2.278 1.00
116_Q 120_R 2.266 1.00
315_R 331_R 2.244 1.00
359_S 362_F 2.237 1.00
316_D 320_W 2.186 1.00
69_Y 75_Q 2.165 1.00
253_I 329_A 2.148 1.00
103_A 107_Q 2.144 1.00
103_A 116_Q 2.102 1.00
312_W 335_A 2.081 1.00
78_R 210_D 2.019 1.00
343_L 399_I 2.018 1.00
331_R 335_A 2.013 1.00
283_L 288_D 1.976 1.00
361_R 365_L 1.947 1.00
99_V 120_R 1.939 1.00
146_A 150_L 1.939 1.00
158_I 185_L 1.903 1.00
121_L 173_E 1.862 1.00
332_D 388_L 1.861 1.00
102_A 120_R 1.855 1.00
98_F 123_A 1.855 1.00
316_D 331_R 1.848 1.00
66_V 141_G 1.835 1.00
389_G 393_A 1.819 1.00
336_W 392_Q 1.809 1.00
27_L 164_Y 1.804 1.00
294_V 298_K 1.756 1.00
276_L 296_S 1.754 1.00
151_S 190_A 1.748 1.00
33_G 36_G 1.718 1.00
151_S 189_P 1.709 1.00
124_L 127_M 1.701 1.00
293_V 350_F 1.68 1.00
11_A 271_S 1.666 1.00
359_S 408_V 1.664 1.00
293_V 353_L 1.664 1.00
385_H 392_Q 1.663 1.00
143_R 282_R 1.646 1.00
80_V 138_L 1.637 1.00
210_D 213_L 1.623 1.00
286_K 290_T 1.619 1.00
27_L 167_Y 1.606 1.00
131_W 187_V 1.604 1.00
370_Q 401_Y 1.601 1.00
121_L 176_L 1.597 1.00
291_R 295_K 1.596 1.00
173_E 177_L 1.591 1.00
28_L 175_A 1.584 1.00
69_Y 72_N 1.573 1.00
155_G 186_V 1.564 1.00
290_T 294_V 1.564 1.00
373_L 400_V 1.54 1.00
317_F 320_W 1.527 1.00
308_S 312_W 1.51 1.00
287_R 291_R 1.507 1.00
87_V 134_L 1.485 1.00
8_L 12_A 1.479 1.00
310_T 314_L 1.469 1.00
128_G 187_V 1.456 1.00
188_I 192_I 1.449 1.00
16_V 153_I 1.449 1.00
403_S 407_G 1.447 1.00
162_A 178_G 1.446 1.00
65_Y 220_F 1.442 1.00
366_A 404_L 1.44 1.00
125_V 180_A 1.438 1.00
333_L 387_A 1.433 1.00
68_Q 358_A 1.429 1.00
25_G 259_S 1.429 1.00
150_L 154_V 1.428 1.00
75_Q 78_R 1.424 1.00
247_S 250_E 1.412 1.00
382_I 390_A 1.409 1.00
135_L 190_A 1.405 0.99
7_S 275_Y 1.403 0.99
226_I 364_I 1.396 0.99
104_P 107_Q 1.394 0.99
161_L 165_V 1.386 0.99
291_R 294_V 1.379 0.99
377_F 393_A 1.378 0.99
24_V 179_L 1.372 0.99
336_W 388_L 1.372 0.99
280_L 289_I 1.372 0.99
393_A 397_T 1.372 0.99
170_G 177_L 1.367 0.99
65_Y 79_V 1.345 0.99
95_A 127_M 1.343 0.99
365_L 369_S 1.339 0.99
298_K 302_P 1.338 0.99
163_Y 175_A 1.337 0.99
300_V 345_V 1.335 0.99
43_F 119_V 1.334 0.99
121_L 177_L 1.324 0.99
86_M 214_A 1.295 0.99
171_G 174_G 1.283 0.99
242_L 246_Y 1.278 0.99
24_V 159_G 1.263 0.99
336_W 395_M 1.262 0.99
304_V 345_V 1.254 0.99
12_A 149_A 1.254 0.99
373_L 377_F 1.252 0.99
328_T 332_D 1.243 0.98
230_T 368_V 1.238 0.98
241_L 382_I 1.234 0.98
174_G 178_G 1.232 0.98
300_V 349_V 1.228 0.98
376_V 380_W 1.227 0.98
377_F 396_A 1.221 0.98
64_K 68_Q 1.218 0.98
250_E 387_A 1.216 0.98
222_L 226_I 1.211 0.98
242_L 390_A 1.21 0.98
302_P 306_A 1.208 0.98
289_I 357_K 1.208 0.98
192_I 196_K 1.198 0.98
329_A 332_D 1.196 0.98
157_L 161_L 1.194 0.98
89_G 93_L 1.192 0.98
96_L 100_L 1.189 0.98
27_L 163_Y 1.183 0.98
34_P 249_D 1.183 0.98
95_A 99_V 1.182 0.98
257_V 333_L 1.179 0.98
102_A 116_Q 1.173 0.98
378_A 382_I 1.168 0.97
99_V 103_A 1.165 0.97
308_S 342_V 1.163 0.97
372_T 376_V 1.162 0.97
238_M 254_W 1.158 0.97
82_T 214_A 1.158 0.97
279_T 292_E 1.158 0.97
328_T 331_R 1.149 0.97
101_A 105_I 1.146 0.97
68_Q 216_Q 1.145 0.97
288_D 291_R 1.143 0.97
158_I 162_A 1.142 0.97
212_G 215_G 1.141 0.97
62_V 66_V 1.14 0.97
343_L 402_F 1.133 0.97
159_G 179_L 1.132 0.97
381_L 393_A 1.128 0.97
238_M 378_A 1.122 0.97
13_S 152_L 1.117 0.96
241_L 378_A 1.113 0.96
385_H 389_G 1.107 0.96
103_A 120_R 1.103 0.96
327_F 330_M 1.099 0.96
100_L 104_P 1.089 0.96
312_W 338_L 1.088 0.96
30_V 324_S 1.088 0.96
147_G 193_M 1.084 0.96
223_M 364_I 1.082 0.96
381_L 389_G 1.081 0.95
73_P 77_R 1.08 0.95
315_R 334_F 1.078 0.95
9_W 146_A 1.078 0.95
83_S 217_L 1.077 0.95
236_I 240_K 1.075 0.95
374_L 378_A 1.065 0.95
216_Q 358_A 1.065 0.95
306_A 309_F 1.064 0.95
346_G 402_F 1.061 0.95
283_L 292_E 1.06 0.95
191_A 195_I 1.058 0.95
213_L 216_Q 1.056 0.95
407_G 410_L 1.055 0.95
85_A 89_G 1.053 0.95
374_L 397_T 1.053 0.95
167_Y 175_A 1.052 0.95
74_Q 78_R 1.052 0.95
366_A 405_C 1.046 0.94
75_Q 213_L 1.045 0.94
317_F 321_L 1.04 0.94
366_A 408_V 1.04 0.94
314_L 318_A 1.039 0.94
332_D 335_A 1.038 0.94
138_L 142_F 1.038 0.94
4_A 8_L 1.037 0.94
319_I 331_R 1.036 0.94
162_A 181_L 1.034 0.94
369_S 372_T 1.031 0.94
102_A 123_A 1.028 0.94
164_Y 168_R 1.026 0.94
15_L 19_G 1.023 0.93
78_R 82_T 1.022 0.93
79_V 213_L 1.02 0.93
67_A 141_G 1.019 0.93
120_R 124_L 1.018 0.93
260_I 318_A 1.015 0.93
253_I 330_M 1.015 0.93
135_L 187_V 1.014 0.93
347_A 398_Y 1.007 0.93
161_L 164_Y 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4lz6A10.99281000.212Contact Map0.579
3w4tA10.99041000.217Contact Map0.71
4humA10.9881000.226Contact Map0.325
3mktA20.98561000.239Contact Map0.391
2xutA30.937510.10.953Contact Map0.176
3wdoA10.44713.50.962Contact Map0.324
3rfuA40.14423.20.963Contact Map0.532
4apsA20.31491.40.97Contact Map0.28
2kluA10.08411.30.97Contact Map0.248
4lepA20.31011.30.97Contact Map0.246
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 1.1297 seconds.