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OPENSEQ.org
RFBX - Putative O-antigen transporter
UniProt: P37746 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11980
Length: 415 (407)
Sequences: 13813
Seq/Len: 33.94
RFBX
Paralog alert: 0.91 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: DINF MDTK MURJ RFBX WZXC WZXE YEEO YGHQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
77_S 80_K 4.261 1.00
211_R 215_A 3.532 1.00
143_K 146_W 3.402 1.00
46_G 251_N 3.305 1.00
106_M 109_L 3.246 1.00
129_G 184_L 3.019 1.00
311_G 314_I 2.823 1.00
316_V 327_A 2.688 1.00
118_V 173_A 2.366 1.00
6_L 10_R 2.324 1.00
384_K 387_G 2.239 1.00
312_A 332_M 2.231 1.00
312_A 328_V 2.208 1.00
357_Y 360_E 2.207 1.00
313_S 317_K 2.139 1.00
69_Q 73_K 2.135 1.00
207_L 211_R 2.11 1.00
249_N 326_N 2.062 1.00
328_V 332_M 2.043 1.00
67_A 88_V 2.042 1.00
340_L 397_C 2.023 1.00
309_L 332_M 2.014 1.00
122_S 173_A 1.99 1.00
83_S 206_S 1.973 1.00
278_T 285_K 1.956 1.00
359_K 363_K 1.947 1.00
72_A 276_S 1.909 1.00
329_I 386_I 1.898 1.00
145_K 149_L 1.886 1.00
150_S 189_I 1.835 1.00
313_S 328_V 1.798 1.00
150_S 190_A 1.775 1.00
291_K 295_T 1.774 1.00
333_I 390_I 1.748 1.00
71_I 140_G 1.733 1.00
387_G 391_T 1.728 1.00
279_L 355_H 1.724 1.00
154_S 186_A 1.715 1.00
357_Y 406_F 1.711 1.00
383_F 390_I 1.706 1.00
271_I 293_S 1.695 1.00
32_Y 163_F 1.682 1.00
38_G 41_N 1.678 1.00
157_A 185_V 1.676 1.00
290_I 351_V 1.654 1.00
103_L 124_V 1.653 1.00
164_I 168_T 1.653 1.00
16_A 266_P 1.643 1.00
32_Y 166_V 1.641 1.00
288_I 292_K 1.64 1.00
368_A 399_V 1.638 1.00
290_I 347_Y 1.628 1.00
104_T 121_W 1.61 1.00
278_T 283_R 1.608 1.00
173_A 177_F 1.598 1.00
287_V 291_K 1.587 1.00
206_S 209_N 1.576 1.00
33_L 175_A 1.569 1.00
222_I 362_S 1.568 1.00
170_S 177_F 1.564 1.00
74_A 80_K 1.561 1.00
243_G 246_S 1.545 1.00
279_L 286_G 1.542 1.00
125_P 128_V 1.535 1.00
13_I 17_V 1.516 1.00
314_I 317_K 1.506 1.00
117_A 121_W 1.503 1.00
116_H 244_P 1.501 1.00
85_F 137_L 1.498 1.00
305_S 309_L 1.498 1.00
107_T 121_W 1.494 1.00
275_I 286_G 1.493 1.00
122_S 176_G 1.48 1.00
161_L 178_I 1.477 1.00
371_L 398_L 1.477 1.00
284_V 288_I 1.46 1.00
277_S 281_L 1.458 1.00
307_I 311_G 1.452 1.00
401_S 405_M 1.447 1.00
12_V 270_A 1.438 1.00
330_V 385_E 1.437 1.00
234_I 250_F 1.43 1.00
80_K 83_S 1.43 1.00
380_T 388_A 1.429 1.00
364_I 402_L 1.422 1.00
188_I 192_A 1.421 1.00
30_F 255_T 1.417 1.00
142_E 277_S 1.412 1.00
149_L 153_L 1.398 0.99
237_I 380_T 1.398 0.99
391_T 395_T 1.395 0.99
363_K 367_A 1.386 0.99
132_I 187_G 1.378 0.99
129_G 187_G 1.373 0.99
160_P 164_I 1.372 0.99
288_I 291_K 1.37 0.99
162_T 175_A 1.363 0.99
238_L 388_A 1.358 0.99
21_S 152_I 1.357 0.99
126_A 180_S 1.346 0.99
333_I 386_I 1.345 0.99
29_T 179_Q 1.336 0.99
295_T 299_L 1.33 0.99
122_S 177_F 1.325 0.99
100_L 104_T 1.325 0.99
174_I 178_I 1.308 0.99
371_L 375_L 1.304 0.99
375_L 391_T 1.299 0.99
78_K 82_T 1.298 0.99
234_I 376_I 1.296 0.99
226_A 366_I 1.29 0.99
218_F 222_I 1.29 0.99
333_I 393_L 1.287 0.99
105_S 109_L 1.282 0.99
314_I 318_I 1.279 0.99
164_I 167_N 1.277 0.99
165_F 170_S 1.275 0.99
297_L 342_S 1.271 0.99
301_G 342_S 1.267 0.99
237_I 376_I 1.266 0.99
238_L 250_F 1.263 0.99
45_F 172_I 1.263 0.99
74_A 77_S 1.262 0.99
106_M 110_V 1.251 0.99
100_L 128_V 1.249 0.99
91_S 210_V 1.247 0.99
134_P 190_A 1.246 0.98
238_L 242_S 1.246 0.98
70_S 216_D 1.233 0.98
66_T 69_Q 1.231 0.98
17_V 148_T 1.227 0.98
340_L 400_T 1.22 0.98
253_A 330_V 1.208 0.98
108_L 112_E 1.197 0.98
285_K 288_I 1.192 0.98
297_L 346_V 1.188 0.98
375_L 394_A 1.184 0.98
156_L 160_P 1.183 0.98
171_D 174_I 1.18 0.98
35_R 321_G 1.18 0.98
29_T 158_I 1.175 0.98
374_L 378_P 1.172 0.98
80_K 209_N 1.169 0.97
104_T 108_L 1.169 0.97
326_N 329_I 1.168 0.97
274_R 289_L 1.168 0.97
122_S 180_S 1.166 0.97
94_V 98_I 1.165 0.97
305_S 339_F 1.157 0.97
286_G 355_H 1.157 0.97
208_H 211_R 1.15 0.97
108_L 117_A 1.147 0.97
66_T 70_S 1.147 0.97
166_V 175_A 1.144 0.97
246_S 385_E 1.139 0.97
237_I 377_F 1.138 0.97
309_L 335_S 1.135 0.97
39_P 322_P 1.134 0.97
70_S 73_K 1.132 0.97
192_A 196_H 1.128 0.97
157_A 161_L 1.128 0.97
325_D 329_I 1.124 0.97
9_R 13_I 1.121 0.97
299_L 303_A 1.121 0.97
70_S 84_I 1.115 0.96
370_L 374_L 1.113 0.96
219_H 362_S 1.113 0.96
48_C 120_I 1.112 0.96
205_L 210_V 1.111 0.96
364_I 403_M 1.109 0.96
66_T 72_A 1.107 0.96
212_R 356_N 1.099 0.96
87_A 210_V 1.098 0.96
79_D 83_S 1.097 0.96
18_V 151_S 1.097 0.96
126_A 183_N 1.097 0.96
101_I 105_S 1.096 0.96
383_F 387_G 1.095 0.96
325_D 328_V 1.094 0.96
379_L 391_T 1.092 0.96
32_Y 162_T 1.091 0.96
173_A 176_G 1.091 0.96
238_L 385_E 1.088 0.96
376_I 380_T 1.081 0.95
67_A 71_I 1.08 0.95
69_Q 72_A 1.077 0.95
20_G 24_L 1.074 0.95
39_P 245_T 1.07 0.95
316_V 328_V 1.07 0.95
372_S 395_T 1.064 0.95
379_L 383_F 1.064 0.95
137_L 141_K 1.062 0.95
43_G 248_G 1.061 0.95
73_K 356_N 1.057 0.95
238_L 247_V 1.057 0.95
360_E 406_F 1.045 0.94
88_V 213_S 1.042 0.94
350_Q 354_T 1.042 0.94
278_T 289_L 1.04 0.94
160_P 163_F 1.039 0.94
309_L 313_S 1.037 0.94
377_F 381_T 1.037 0.94
107_T 124_V 1.032 0.94
311_G 315_L 1.031 0.94
163_F 166_V 1.027 0.94
146_W 193_I 1.023 0.93
367_A 370_L 1.018 0.93
225_S 229_L 1.014 0.93
343_L 400_T 1.012 0.93
14_Y 145_K 1.01 0.93
303_A 306_L 1.008 0.93
344_S 396_E 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4lz6A10.99521000.251Contact Map0.544
4humA10.99041000.255Contact Map0.334
3w4tA10.99281000.258Contact Map0.685
3mktA20.9881000.262Contact Map0.389
2xutA30.920518.40.949Contact Map0.177
1pw4A10.89644.30.961Contact Map0.156
4jr9A10.88672.60.965Contact Map0.159
3wdoA10.450620.967Contact Map0.336
3rfuA40.15661.80.968Contact Map0.689
1nkzB30.09881.70.969Contact Map0.215
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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