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RLUC - Ribosomal large subunit pseudouridine synthase C
UniProt: P0AA39 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11118
Length: 319 (307)
Sequences: 4127
Seq/Len: 13.44
RLUC
Paralog alert: 0.88 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: RLUA RLUB RLUC RLUD RLUE RLUF RSUA TRUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
96_L 150_V 5.091 1.00
50_N 64_D 4.942 1.00
175_D 233_R 4.011 1.00
224_E 316_R 3.933 1.00
219_R 237_V 3.902 1.00
221_K 233_R 3.439 1.00
94_V 106_N 3.381 1.00
288_K 299_R 3.316 1.00
98_E 155_K 3.146 1.00
190_S 219_R 3.139 1.00
101_H 293_G 3.089 1.00
101_H 156_K 3.064 1.00
286_A 299_R 2.948 1.00
106_N 302_A 2.919 1.00
177_L 231_L 2.652 1.00
177_L 285_A 2.636 1.00
193_A 250_Y 2.615 1.00
189_K 220_F 2.609 1.00
279_R 307_G 2.541 1.00
187_H 225_R 2.461 1.00
104_V 300_I 2.425 1.00
222_V 230_T 2.346 1.00
234_C 248_T 2.274 1.00
192_Q 215_P 2.269 1.00
217_E 237_V 2.239 1.00
22_I 54_I 2.196 1.00
156_K 159_A 2.109 1.00
290_T 297_V 2.051 1.00
190_S 217_E 2.019 1.00
166_Q 171_G 2.014 1.00
288_K 297_V 2.01 1.00
286_A 301_E 1.994 1.00
218_T 234_C 1.99 1.00
173_Q 235_S 1.972 1.00
178_A 234_C 1.972 1.00
192_Q 217_E 1.972 1.00
223_E 233_R 1.963 1.00
99_D 291_H 1.938 1.00
143_L 151_L 1.924 1.00
306_E 310_R 1.918 1.00
148_S 283_H 1.908 1.00
14_T 17_E 1.905 1.00
281_F 308_L 1.903 1.00
188_V 221_K 1.902 1.00
174_K 236_P 1.866 1.00
184_W 230_T 1.847 1.00
232_V 248_T 1.821 1.00
49_V 58_Y 1.787 1.00
54_I 58_Y 1.779 1.00
173_Q 288_K 1.7 1.00
175_D 286_A 1.69 1.00
234_C 244_I 1.688 1.00
175_D 235_S 1.68 1.00
104_V 150_V 1.674 1.00
165_E 169_E 1.66 1.00
96_L 300_I 1.658 1.00
104_V 152_L 1.656 1.00
225_R 230_T 1.637 1.00
146_D 280_L 1.611 1.00
218_T 236_P 1.609 1.00
48_R 67_R 1.592 1.00
162_S 166_Q 1.571 1.00
180_V 232_V 1.553 1.00
191_V 251_A 1.531 1.00
177_L 233_R 1.504 1.00
99_D 102_I 1.501 1.00
140_V 154_A 1.487 1.00
281_F 311_C 1.482 1.00
291_H 298_M 1.482 1.00
195_L 246_V 1.47 1.00
102_I 289_F 1.458 1.00
182_G 230_T 1.442 1.00
277_L 281_F 1.428 1.00
113_V 151_L 1.419 1.00
209_V 250_Y 1.41 1.00
60_L 66_V 1.408 1.00
160_L 164_H 1.386 0.99
25_F 60_L 1.386 0.99
25_F 29_Q 1.381 0.99
158_S 293_G 1.376 0.99
109_S 148_S 1.373 0.99
108_P 111_T 1.357 0.99
89_A 121_F 1.357 0.99
190_S 237_V 1.346 0.99
220_F 248_T 1.344 0.99
178_A 255_I 1.324 0.99
91_L 122_G 1.311 0.99
162_S 165_E 1.293 0.99
236_P 244_I 1.286 0.99
285_A 301_E 1.27 0.99
179_L 311_C 1.267 0.99
177_L 223_E 1.253 0.99
12_A 65_E 1.249 0.99
219_R 235_S 1.248 0.99
49_V 66_V 1.244 0.98
304_M 308_L 1.232 0.98
279_R 283_H 1.231 0.98
110_G 148_S 1.224 0.98
196_L 210_S 1.222 0.98
177_L 304_M 1.218 0.98
123_V 151_L 1.211 0.98
102_I 159_A 1.21 0.98
26_L 38_I 1.21 0.98
248_T 255_I 1.206 0.98
203_G 206_I 1.199 0.98
39_Y 43_R 1.191 0.98
178_A 232_V 1.19 0.98
122_G 125_E 1.187 0.98
140_V 163_L 1.186 0.98
89_A 120_S 1.18 0.98
191_V 248_T 1.176 0.98
125_E 128_R 1.173 0.98
174_K 237_V 1.171 0.98
180_V 248_T 1.168 0.97
310_R 314_K 1.167 0.97
27_R 35_K 1.164 0.97
26_L 47_V 1.157 0.97
167_L 174_K 1.151 0.97
182_G 253_H 1.149 0.97
150_V 300_I 1.147 0.97
179_L 229_A 1.142 0.97
22_I 42_L 1.139 0.97
309_K 313_Q 1.13 0.97
139_L 153_V 1.116 0.96
222_V 225_R 1.116 0.96
291_H 294_T 1.105 0.96
109_S 279_R 1.103 0.96
195_L 207_V 1.098 0.96
42_L 47_V 1.09 0.96
283_H 302_A 1.09 0.96
37_M 41_I 1.09 0.96
277_L 308_L 1.081 0.95
180_V 253_H 1.069 0.95
157_R 160_L 1.066 0.95
101_H 159_A 1.064 0.95
218_T 247_H 1.061 0.95
189_K 222_V 1.056 0.95
101_H 291_H 1.052 0.95
180_V 255_I 1.047 0.94
181_R 256_A 1.04 0.94
96_L 303_P 1.038 0.94
102_I 291_H 1.029 0.94
180_V 230_T 1.026 0.94
229_A 256_A 1.022 0.93
281_F 307_G 1.011 0.93
183_Q 225_R 1.005 0.93
40_R 44_K 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v9fA10.9531000.184Contact Map0.9
1v9kA20.71471000.29Contact Map0.832
2i82A40.66461000.36Contact Map0.913
4lgtA20.76491000.447Contact Map0.596
3dh3A40.75241000.45Contact Map0.525
1vioA20.74921000.457Contact Map0.677
1kskA10.72411000.462Contact Map0.64
2olwA20.66461000.524Contact Map0.613
2omlA10.54231000.53Contact Map0.652
2gmlA20.64891000.585Contact Map0.686
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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