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TRUC - tRNA pseudouridine synthase C
UniProt: P0AA41 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13171
Length: 260 (230)
Sequences: 5408
Seq/Len: 23.51

TRUC
Paralog alert: 0.91 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: RLUA RLUB RLUC RLUD RLUE RLUF RSUA TRUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
128_H 157_K 3.748 1.00
5_L 60_V 3.672 1.00
85_R 153_E 3.668 1.00
205_Q 218_T 3.191 1.00
7_Q 65_L 3.189 1.00
207_S 218_T 3.155 1.00
130_R 153_E 3.148 1.00
99_V 128_H 2.937 1.00
3_E 15_N 2.901 1.00
10_W 66_S 2.827 1.00
87_H 204_S 2.807 1.00
154_L 168_L 2.788 1.00
10_W 212_F 2.733 1.00
98_A 129_Y 2.603 1.00
133_A 235_G 2.594 1.00
13_A 219_I 2.539 1.00
87_H 151_L 2.467 1.00
66_S 69_A 2.434 1.00
15_N 221_A 2.412 1.00
99_V 126_V 2.41 1.00
154_L 164_L 2.385 1.00
209_T 216_P 2.315 1.00
198_R 226_T 2.266 1.00
207_S 216_P 2.199 1.00
102_Y 170_H 2.165 1.00
205_Q 220_H 2.114 1.00
97_E 130_R 2.097 1.00
131_G 150_G 2.045 1.00
126_V 157_K 2.025 1.00
8_D 210_H 1.959 1.00
58_S 202_H 1.94 1.00
76_Q 81_Q 1.922 1.00
75_Q 79_Q 1.882 1.00
83_Q 207_S 1.818 1.00
85_R 205_Q 1.811 1.00
101_D 126_V 1.804 1.00
90_V 152_V 1.782 1.00
35_V 61_L 1.779 1.00
94_L 150_G 1.766 1.00
83_Q 155_E 1.764 1.00
127_T 154_L 1.763 1.00
132_L 153_E 1.758 1.00
88_A 154_L 1.757 1.00
85_R 155_E 1.731 1.00
96_E 134_T 1.724 1.00
101_D 124_P 1.71 1.00
13_A 62_L 1.683 1.00
53_L 61_L 1.655 1.00
152_V 168_L 1.63 1.00
200_M 227_W 1.593 1.00
225_D 229_Q 1.58 1.00
84_K 156_P 1.575 1.00
92_G 150_G 1.571 1.00
87_H 153_E 1.55 1.00
8_D 11_L 1.541 1.00
72_L 76_Q 1.531 1.00
13_A 60_V 1.526 1.00
22_V 61_L 1.501 1.00
128_H 155_E 1.501 1.00
90_V 168_L 1.493 1.00
131_G 134_T 1.437 1.00
70_G 74_A 1.428 1.00
204_S 220_H 1.419 1.00
210_H 217_L 1.394 0.99
56_P 199_L 1.377 0.99
5_L 219_I 1.374 0.99
33_V 38_T 1.363 0.99
104_L 166_R 1.337 0.99
72_L 75_Q 1.331 0.99
196_L 200_M 1.281 0.99
87_H 223_L 1.264 0.99
50_A 73_L 1.26 0.99
50_A 64_G 1.258 0.99
11_L 208_L 1.252 0.99
100_L 171_L 1.246 0.98
76_Q 209_T 1.231 0.98
156_P 164_L 1.214 0.98
168_L 175_I 1.209 0.98
99_V 157_K 1.192 0.98
17_P 20_W 1.191 0.98
134_T 150_G 1.185 0.98
77_F 156_P 1.182 0.98
202_H 221_A 1.172 0.98
39_V 63_M 1.16 0.97
10_W 69_A 1.149 0.97
228_M 232_S 1.133 0.97
34_V 37_Q 1.127 0.97
18_S 58_S 1.126 0.97
88_A 175_I 1.126 0.97
94_L 152_V 1.121 0.97
153_E 204_S 1.119 0.96
68_E 212_F 1.118 0.96
127_T 167_H 1.115 0.96
87_H 132_L 1.114 0.96
20_W 35_V 1.111 0.96
209_T 214_G 1.11 0.96
75_Q 78_E 1.102 0.96
229_Q 233_Q 1.099 0.96
92_G 173_H 1.096 0.96
60_V 219_I 1.088 0.96
100_L 167_H 1.084 0.96
11_L 210_H 1.078 0.95
22_V 53_L 1.077 0.95
10_W 210_H 1.069 0.95
198_R 202_H 1.065 0.95
77_F 82_I 1.065 0.95
93_W 134_T 1.062 0.95
35_V 63_M 1.056 0.95
127_T 156_P 1.047 0.94
18_S 198_R 1.042 0.94
14_V 35_V 1.038 0.94
200_M 230_A 1.038 0.94
71_R 75_Q 1.026 0.94
149_Y 176_I 1.022 0.93
20_W 38_T 1.02 0.93
89_I 149_Y 1.008 0.93
203_A 206_L 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v9fA10.89621000.26Contact Map0.885
1v9kA20.86151000.265Contact Map0.848
2i82A40.78851000.31Contact Map0.919
2olwA20.71000.483Contact Map0.675
2omlA10.70381000.496Contact Map0.684
4lgtA20.73461000.506Contact Map0.548
3dh3A40.77691000.523Contact Map0.456
1vioA20.72311000.528Contact Map0.624
1kskA10.68081000.535Contact Map0.578
2gmlA20.851000.558Contact Map0.716

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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