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DCTA - Aerobic C4-dicarboxylate transport protein
UniProt: P0A830 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG20044
Length: 428 (408)
Sequences: 2945
Seq/Len: 7.22
DCTA
Paralog alert: 0.73 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: DCTA GLTP SSTT YDJN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
143_G 147_S 3.894 1.00
281_E 287_K 3.149 1.00
136_V 155_L 3.127 1.00
76_V 402_V 2.917 1.00
172_Q 176_N 2.874 1.00
95_I 229_T 2.865 1.00
97_N 329_Q 2.863 1.00
84_V 241_I 2.728 1.00
169_S 172_Q 2.684 1.00
273_L 294_I 2.632 1.00
40_G 137_I 2.628 1.00
19_I 201_F 2.472 1.00
23_L 201_F 2.468 1.00
173_L 180_S 2.44 1.00
174_I 177_V 2.408 1.00
106_N 321_N 2.398 1.00
100_Q 103_A 2.343 1.00
187_G 190_N 2.329 1.00
54_F 58_V 2.327 1.00
14_L 18_A 2.315 1.00
54_F 157_A 2.309 1.00
22_L 26_F 2.272 1.00
55_C 181_F 2.243 1.00
325_D 328_H 2.225 1.00
48_I 192_I 2.224 1.00
160_F 184_V 2.213 1.00
58_V 178_I 2.194 1.00
400_K 407_H 2.184 1.00
286_R 404_E 2.155 1.00
224_I 228_I 2.13 1.00
35_K 39_D 2.084 1.00
80_Y 394_A 2.059 1.00
37_L 202_G 2.049 1.00
12_Q 194_R 2.037 1.00
278_D 282_K 1.998 1.00
316_I 368_G 1.986 1.00
227_Y 382_A 1.985 1.00
96_V 314_V 1.978 1.00
285_C 396_I 1.974 1.00
141_V 156_F 1.936 1.00
259_E 279_K 1.928 1.00
94_I 98_V 1.913 1.00
380_S 384_A 1.849 1.00
101_P 318_Q 1.841 1.00
95_I 232_L 1.839 1.00
16_A 201_F 1.824 1.00
376_D 383_R 1.813 1.00
131_A 135_D 1.809 1.00
8_S 11_F 1.789 1.00
139_A 143_G 1.786 1.00
286_R 399_A 1.782 1.00
72_R 402_V 1.775 1.00
99_V 225_C 1.774 1.00
168_G 171_G 1.772 1.00
260_L 389_V 1.736 1.00
217_V 221_Q 1.723 1.00
223_I 375_I 1.718 1.00
75_A 79_L 1.699 1.00
174_I 180_S 1.679 1.00
76_V 401_W 1.678 1.00
174_I 184_V 1.652 1.00
164_L 184_V 1.615 1.00
72_R 76_V 1.607 1.00
230_C 382_A 1.605 1.00
229_T 307_I 1.604 1.00
23_L 27_Y 1.6 1.00
149_N 152_Q 1.59 1.00
280_M 392_G 1.59 1.00
320_T 368_G 1.584 1.00
16_A 20_G 1.58 1.00
63_G 179_E 1.573 1.00
286_R 289_V 1.564 1.00
55_C 185_I 1.562 1.00
230_C 386_T 1.55 1.00
142_I 145_F 1.537 1.00
96_V 311_M 1.528 0.99
166_R 187_G 1.525 0.99
220_G 224_I 1.508 0.99
323_Q 327_V 1.504 0.99
285_C 399_A 1.496 0.99
142_I 146_A 1.489 0.99
177_V 180_S 1.489 0.99
95_I 225_C 1.487 0.99
22_L 25_H 1.472 0.99
11_F 15_T 1.442 0.99
276_M 392_G 1.439 0.99
93_L 329_Q 1.426 0.99
99_V 228_I 1.424 0.99
46_K 139_A 1.423 0.99
9_L 13_V 1.421 0.99
61_I 158_V 1.414 0.99
90_I 94_I 1.412 0.99
308_Y 383_R 1.41 0.99
160_F 181_F 1.401 0.99
40_G 134_M 1.389 0.99
90_I 330_I 1.378 0.99
191_M 195_L 1.377 0.99
256_I 392_G 1.375 0.99
276_M 294_I 1.354 0.98
137_I 155_L 1.346 0.98
167_L 171_G 1.336 0.98
173_L 176_N 1.329 0.98
305_T 350_G 1.326 0.98
308_Y 376_D 1.317 0.98
163_A 191_M 1.311 0.98
272_A 276_M 1.31 0.98
255_Y 283_L 1.308 0.98
278_D 281_E 1.302 0.98
39_D 43_K 1.302 0.98
293_V 395_T 1.29 0.98
316_I 364_L 1.287 0.98
250_F 254_R 1.285 0.98
234_V 386_T 1.275 0.97
217_V 220_G 1.262 0.97
248_S 251_K 1.258 0.97
179_E 183_Q 1.253 0.97
18_A 22_L 1.251 0.97
303_D 340_S 1.244 0.97
299_S 302_L 1.238 0.97
270_E 345_G 1.235 0.97
236_L 240_S 1.235 0.97
267_S 377_R 1.224 0.97
280_M 294_I 1.223 0.97
35_K 206_F 1.217 0.96
163_A 188_I 1.215 0.96
252_F 256_I 1.214 0.96
399_A 405_L 1.209 0.96
47_M 156_F 1.208 0.96
48_I 189_I 1.207 0.96
185_I 189_I 1.207 0.96
43_K 139_A 1.198 0.96
276_M 388_L 1.197 0.96
326_I 330_I 1.192 0.96
235_V 239_G 1.184 0.96
233_F 237_V 1.181 0.96
206_F 210_K 1.181 0.96
251_K 254_R 1.171 0.95
252_F 392_G 1.168 0.95
57_V 154_L 1.166 0.95
247_F 405_L 1.165 0.95
185_I 192_I 1.156 0.95
256_I 389_V 1.155 0.95
406_D 409_K 1.154 0.95
243_K 246_G 1.152 0.95
345_G 348_G 1.152 0.95
405_L 410_L 1.15 0.95
84_V 303_D 1.146 0.94
79_L 83_I 1.143 0.94
232_L 236_L 1.143 0.94
170_K 183_Q 1.141 0.94
62_A 175_F 1.137 0.94
90_I 333_L 1.13 0.94
218_Q 221_Q 1.112 0.93
277_L 290_V 1.112 0.93
177_V 184_V 1.104 0.93
190_N 278_D 1.102 0.93
339_S 357_T 1.097 0.93
221_Q 224_I 1.095 0.93
221_Q 318_Q 1.091 0.92
313_A 332_L 1.09 0.92
226_F 379_M 1.086 0.92
326_I 329_Q 1.085 0.92
50_A 153_V 1.084 0.92
77_A 293_V 1.082 0.92
205_A 209_G 1.081 0.92
187_G 191_M 1.077 0.92
335_V 360_A 1.074 0.92
158_V 162_F 1.074 0.92
259_E 272_A 1.07 0.91
309_L 354_L 1.061 0.91
135_D 149_N 1.061 0.91
140_S 144_A 1.058 0.91
263_V 384_A 1.058 0.91
164_L 174_I 1.056 0.91
9_L 12_Q 1.053 0.90
345_G 349_S 1.052 0.90
351_F 373_L 1.048 0.90
298_Y 302_L 1.036 0.90
400_K 403_K 1.036 0.90
166_R 191_M 1.032 0.89
130_V 134_M 1.03 0.89
347_T 380_S 1.027 0.89
87_I 91_I 1.025 0.89
245_T 400_K 1.022 0.89
312_A 376_D 1.019 0.88
323_Q 328_H 1.018 0.88
302_L 391_N 1.018 0.88
70_V 162_F 1.014 0.88
40_G 155_L 1.01 0.88
260_L 385_L 1.006 0.88
289_V 399_A 1.005 0.88
247_F 410_L 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nwlA30.93221000.122Contact Map0.738
2l0eA10.072430.981Contact Map0.176
2llzA10.10052.90.981Contact Map0
2ooaA20.11922.70.982Contact Map0.786
3ffyA10.21962.60.982Contact Map0.305
2zhjA10.16822.40.982Contact Map0
2ls4A10.05612.40.982Contact Map0.179
3ffvA20.13552.30.982Contact Map0.275
4dveA30.182220.983Contact Map0.671
1ji6A10.21731.80.983Contact Map0.183
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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