May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YDJN - Uncharacterized symporter YdjN
UniProt: P77529 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13990
Length: 463 (425)
Sequences: 2907
Seq/Len: 6.84
YDJN
Paralog alert: 0.72 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: DCTA GLTP SSTT YDJN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
177_A 181_G 3.675 1.00
170_F 192_I 3.238 1.00
107_L 444_L 3.096 1.00
126_V 270_G 3.054 1.00
213_E 217_A 3.046 1.00
128_N 372_I 2.984 1.00
71_G 171_I 2.776 1.00
313_I 335_A 2.752 1.00
34_L 38_V 2.65 1.00
115_T 281_L 2.632 1.00
43_F 242_L 2.53 1.00
85_F 89_L 2.441 1.00
214_R 221_T 2.438 1.00
85_F 194_A 2.436 1.00
327_P 446_Q 2.424 1.00
228_K 231_R 2.384 1.00
89_L 219_I 2.383 1.00
39_M 242_L 2.368 1.00
79_I 233_V 2.351 1.00
210_P 213_E 2.329 1.00
42_V 46_A 2.303 1.00
265_V 269_L 2.293 1.00
215_V 218_A 2.271 1.00
368_D 371_W 2.188 1.00
86_A 222_L 2.188 1.00
32_K 235_Q 2.134 1.00
197_L 225_W 2.121 1.00
442_Q 449_K 2.121 1.00
358_V 410_L 2.112 1.00
268_Y 424_G 2.111 1.00
322_R 328_E 2.107 1.00
318_E 323_R 2.071 1.00
68_V 243_A 2.067 1.00
66_N 70_N 2.048 1.00
111_T 436_A 2.044 1.00
299_V 319_A 2.034 1.00
127_T 356_V 2.006 1.00
326_V 438_T 1.971 1.00
327_P 441_S 1.94 1.00
165_Q 169_S 1.923 1.00
36_G 242_L 1.922 1.00
103_K 444_L 1.918 1.00
318_E 322_R 1.886 1.00
28_S 31_K 1.868 1.00
106_F 110_G 1.856 1.00
418_E 425_R 1.855 1.00
300_L 431_S 1.843 1.00
125_L 129_L 1.814 1.00
132_L 360_P 1.802 1.00
258_I 262_S 1.8 1.00
270_G 349_L 1.785 1.00
215_V 221_T 1.78 1.00
130_F 266_A 1.779 1.00
43_F 47_L 1.771 1.00
264_V 417_V 1.767 1.00
173_K 177_A 1.764 1.00
365_N 368_D 1.737 1.00
327_P 330_I 1.729 1.00
422_D 426_T 1.705 1.00
103_K 107_L 1.701 1.00
121_L 125_L 1.69 1.00
201_A 225_W 1.685 1.00
36_G 40_G 1.68 1.00
175_P 193_F 1.679 1.00
271_L 428_L 1.678 1.00
271_L 424_G 1.67 1.00
176_F 180_T 1.654 1.00
126_V 266_A 1.631 1.00
362_V 410_L 1.628 1.00
107_L 443_W 1.627 1.00
365_N 370_M 1.626 1.00
86_A 226_V 1.623 1.00
121_L 373_A 1.616 1.00
326_V 441_S 1.612 1.00
215_V 225_W 1.594 1.00
316_N 434_M 1.593 1.00
176_F 179_L 1.592 1.00
197_L 222_L 1.556 0.99
203_K 228_K 1.552 0.99
232_L 236_L 1.542 0.99
320_Q 434_M 1.517 0.99
42_V 45_L 1.515 0.99
127_T 353_M 1.513 0.99
94_R 220_D 1.511 0.99
261_G 265_V 1.507 0.99
77_Q 173_K 1.496 0.99
346_C 393_A 1.492 0.99
218_A 221_T 1.461 0.99
214_R 217_A 1.449 0.99
92_V 195_A 1.447 0.99
200_A 232_L 1.439 0.99
171_I 192_I 1.435 0.99
71_G 168_L 1.429 0.99
124_V 372_I 1.4 0.99
312_S 316_N 1.399 0.99
110_G 114_F 1.395 0.99
287_V 447_T 1.391 0.99
350_Y 425_R 1.386 0.99
296_V 431_S 1.383 0.99
358_V 406_L 1.377 0.98
290_L 294_R 1.371 0.98
316_N 335_A 1.365 0.98
31_K 35_V 1.364 0.98
344_N 383_S 1.356 0.98
350_Y 418_E 1.349 0.98
220_D 224_S 1.34 0.98
130_F 269_L 1.34 0.98
281_L 439_L 1.335 0.98
70_N 74_Q 1.333 0.98
295_K 324_L 1.33 0.98
310_A 388_G 1.329 0.98
79_I 230_V 1.321 0.98
340_T 343_Q 1.316 0.98
200_A 229_L 1.313 0.98
74_Q 173_K 1.313 0.98
296_V 434_M 1.299 0.98
316_N 430_V 1.297 0.98
334_A 437_G 1.295 0.97
131_G 135_E 1.287 0.97
369_P 373_A 1.286 0.97
388_G 391_G 1.274 0.97
78_M 193_F 1.273 0.97
226_V 230_V 1.27 0.97
369_P 372_I 1.268 0.97
307_R 419_P 1.261 0.97
218_A 225_W 1.26 0.97
441_S 447_T 1.259 0.97
66_N 247_K 1.251 0.97
282_L 435_T 1.246 0.97
118_I 122_V 1.236 0.96
291_K 294_R 1.234 0.96
258_I 261_G 1.233 0.96
378_I 403_A 1.232 0.96
183_N 189_S 1.231 0.96
287_V 452_L 1.217 0.96
276_A 280_I 1.215 0.96
115_T 344_N 1.214 0.96
282_L 287_V 1.211 0.96
88_I 191_V 1.207 0.96
288_S 291_K 1.206 0.96
299_V 312_S 1.204 0.96
226_V 233_V 1.203 0.96
317_V 331_A 1.196 0.95
303_A 426_T 1.191 0.95
283_G 286_G 1.188 0.95
204_L 212_G 1.181 0.95
382_S 400_V 1.176 0.95
292_Y 296_V 1.174 0.95
93_A 216_L 1.172 0.95
38_V 42_V 1.171 0.95
441_S 445_K 1.169 0.95
292_Y 434_M 1.167 0.95
29_L 33_V 1.164 0.95
262_S 360_P 1.162 0.94
373_A 377_G 1.16 0.94
442_Q 445_K 1.155 0.94
108_T 334_A 1.154 0.94
268_Y 272_L 1.154 0.94
255_Q 258_I 1.143 0.94
262_S 265_V 1.137 0.94
355_A 375_L 1.137 0.94
195_A 199_V 1.136 0.94
247_K 251_G 1.135 0.94
267_S 421_I 1.135 0.94
121_L 376_V 1.128 0.93
101_L 199_V 1.128 0.93
390_G 422_D 1.125 0.93
169_S 183_N 1.113 0.93
339_A 343_Q 1.107 0.92
351_P 397_A 1.103 0.92
321_T 328_E 1.1 0.92
272_L 275_F 1.098 0.92
394_T 415_I 1.097 0.92
246_T 250_A 1.093 0.92
203_K 232_L 1.091 0.92
307_R 422_D 1.09 0.92
72_Y 236_L 1.09 0.92
81_M 190_V 1.089 0.92
267_S 353_M 1.088 0.91
39_M 43_F 1.085 0.91
447_T 452_L 1.076 0.91
259_K 262_S 1.074 0.91
285_N 442_Q 1.071 0.91
295_K 299_V 1.065 0.90
228_K 232_L 1.063 0.90
274_M 428_L 1.061 0.90
330_I 441_S 1.057 0.90
100_Q 446_Q 1.051 0.90
300_L 427_A 1.044 0.89
279_G 293_F 1.035 0.89
295_K 319_A 1.035 0.89
365_N 371_W 1.033 0.88
71_G 192_I 1.031 0.88
201_A 215_V 1.03 0.88
126_V 129_L 1.026 0.88
330_I 446_Q 1.025 0.88
448_D 451_I 1.024 0.88
124_V 128_N 1.02 0.88
326_V 331_A 1.015 0.87
343_Q 433_S 1.014 0.87
313_I 339_A 1.014 0.87
320_Q 335_A 1.011 0.87
90_S 219_I 1.005 0.87
217_A 221_T 1.005 0.87
85_F 179_L 1.004 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nwlA30.88551000.166Contact Map0.748
2jwaA20.060550.98Contact Map
4gofA20.105840.981Contact Map0.215
2ks1B10.062630.982Contact Map
2l2tA20.06482.80.983Contact Map
1s7qA10.13172.50.983Contact Map
2l6wA20.06052.40.983Contact Map
3ge3C10.07992.10.984Contact Map1
2zqkM40.06912.10.984Contact Map0.401
3p0kA10.1211.70.985Contact Map0.015
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.4382 seconds.