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FABA - 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
UniProt: P0A6Q3 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10273
Length: 172 (172)
Sequences: 439
Seq/Len: 2.55
FABA
Paralog alert: 0.06 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: FABA FABZ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_R 12_D 3.119 1.00
14_L 32_P 2.632 1.00
118_V 148_V 2.33 1.00
9_T 12_D 2.329 1.00
31_A 73_I 2.3 1.00
17_G 31_A 2.265 1.00
15_A 20_E 2.185 1.00
122_A 150_V 2.152 1.00
94_Y 98_L 2.127 1.00
100_G 136_N 1.994 0.99
15_A 18_R 1.922 0.99
75_D 105_R 1.871 0.99
14_L 18_R 1.833 0.99
128_R 147_E 1.814 0.99
169_T 172_F 1.753 0.98
49_N 130_H 1.683 0.97
128_R 149_L 1.652 0.97
28_Q 74_G 1.646 0.97
75_D 166_F 1.585 0.96
27_P 168_D 1.52 0.95
56_E 128_R 1.474 0.93
10_K 14_L 1.467 0.93
168_D 171_A 1.459 0.93
18_R 73_I 1.439 0.92
90_L 129_I 1.428 0.92
105_R 166_F 1.425 0.92
147_E 154_L 1.424 0.92
10_K 33_N 1.423 0.92
87_M 129_I 1.382 0.90
33_N 37_M 1.372 0.90
50_F 132_K 1.368 0.90
10_K 32_P 1.32 0.87
3_D 171_A 1.319 0.87
150_V 169_T 1.288 0.85
11_E 170_S 1.287 0.85
39_R 60_D 1.269 0.84
5_R 9_T 1.261 0.84
27_P 170_S 1.258 0.83
6_E 21_L 1.253 0.83
14_L 31_A 1.232 0.82
56_E 147_E 1.226 0.81
14_L 55_V 1.223 0.81
101_E 167_Q 1.22 0.81
9_T 14_L 1.218 0.81
46_T 51_D 1.214 0.80
83_G 156_Y 1.196 0.79
28_Q 32_P 1.194 0.79
77_V 166_F 1.192 0.79
77_V 117_Q 1.183 0.78
126_T 149_L 1.178 0.78
37_M 109_V 1.172 0.77
27_P 101_E 1.172 0.77
54_Y 128_R 1.169 0.77
114_F 158_A 1.156 0.76
31_A 146_G 1.153 0.75
2_V 5_R 1.136 0.74
98_L 131_F 1.134 0.74
77_V 105_R 1.133 0.74
42_K 54_Y 1.114 0.72
36_M 90_L 1.108 0.71
153_R 169_T 1.107 0.71
130_H 145_D 1.107 0.71
121_T 170_S 1.105 0.71
136_N 140_I 1.102 0.71
1_M 5_R 1.087 0.69
168_D 172_F 1.087 0.69
6_E 16_S 1.08 0.68
29_L 113_K 1.078 0.68
4_K 171_A 1.073 0.68
39_R 58_E 1.07 0.67
149_L 152_G 1.069 0.67
3_D 170_S 1.065 0.67
153_R 172_F 1.065 0.67
132_K 145_D 1.059 0.66
122_A 169_T 1.056 0.66
96_G 142_G 1.053 0.66
154_L 157_T 1.041 0.64
18_R 31_A 1.032 0.63
7_S 11_E 1.027 0.63
135_V 141_M 1.027 0.63
109_V 112_V 1.027 0.63
5_R 171_A 1.025 0.62
126_T 152_G 1.019 0.62
86_A 125_V 1.014 0.61
3_D 8_Y 1.014 0.61
9_T 50_F 1.011 0.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4b0bA20.98841000.3Contact Map0.527
2cf2C20.99421000.322Contact Map0.031
3q62A20.99421000.328Contact Map0.526
2gllA60.84881000.528Contact Map0.445
1u1zA60.85471000.531Contact Map0.401
1z6bA60.854799.90.559Contact Map0.474
4h4gA90.866399.90.578Contact Map0.447
4i83A60.84399.90.582Contact Map0.384
3d6xA60.808199.90.599Contact Map0.438
3esiA40.726799.70.69Contact Map0.414
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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