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FABZ - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
UniProt: P0A6Q6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11284
Length: 151 (143)
Sequences: 1468
Seq/Len: 10.27

FABZ
Paralog alert: 0.18 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: FABA FABZ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_E 36_R 3.651 1.00
70_M 113_M 3.256 1.00
103_R 136_K 3.127 1.00
40_A 73_A 2.845 1.00
96_I 99_A 2.804 1.00
66_I 111_M 2.474 1.00
99_A 141_A 2.406 1.00
41_V 110_Q 2.282 1.00
50_F 61_F 2.255 1.00
39_R 112_I 2.249 1.00
69_A 113_M 2.203 1.00
98_E 142_T 2.202 1.00
116_T 128_K 2.158 1.00
29_V 40_A 1.996 1.00
74_T 127_F 1.976 1.00
9_Q 12_E 1.928 1.00
30_L 41_V 1.912 1.00
128_K 142_T 1.843 1.00
115_V 129_G 1.814 1.00
132_L 137_V 1.797 1.00
36_R 116_T 1.765 1.00
49_P 52_Q 1.763 1.00
58_K 104_P 1.761 1.00
130_V 137_V 1.743 1.00
66_I 139_C 1.713 1.00
41_V 112_I 1.676 1.00
31_D 37_F 1.664 1.00
58_K 90_L 1.616 1.00
129_G 143_M 1.609 1.00
12_E 15_E 1.605 1.00
132_L 135_G 1.579 1.00
39_R 114_E 1.547 1.00
33_E 37_F 1.538 1.00
38_L 77_L 1.456 1.00
114_E 132_L 1.455 1.00
26_V 73_A 1.444 1.00
92_Y 104_P 1.439 1.00
31_D 39_R 1.381 0.99
21_F 52_Q 1.381 0.99
66_I 131_A 1.372 0.99
114_E 130_V 1.372 0.99
38_L 73_A 1.372 0.99
67_L 99_A 1.368 0.99
60_I 92_Y 1.325 0.99
43_N 110_Q 1.318 0.99
105_V 138_V 1.27 0.99
14_L 57_G 1.263 0.99
61_F 65_L 1.248 0.99
54_H 63_G 1.239 0.98
103_R 138_V 1.232 0.98
11_E 58_K 1.199 0.98
58_K 106_V 1.192 0.98
113_M 131_A 1.185 0.98
37_F 114_E 1.182 0.98
67_L 96_I 1.182 0.98
74_T 115_V 1.179 0.98
44_V 61_F 1.17 0.97
28_R 41_V 1.16 0.97
93_F 96_I 1.154 0.97
17_L 75_G 1.138 0.97
100_R 144_M 1.132 0.97
55_F 63_G 1.128 0.97
37_F 116_T 1.127 0.97
29_V 76_I 1.117 0.96
21_F 47_N 1.111 0.96
94_A 146_A 1.103 0.96
125_T 145_C 1.097 0.96
30_L 112_I 1.09 0.96
14_L 46_V 1.09 0.96
10_I 46_V 1.068 0.95
118_E 128_K 1.062 0.95
95_G 100_R 1.048 0.94
54_H 64_V 1.043 0.94
11_E 14_L 1.04 0.94
91_Y 145_C 1.034 0.94
29_V 73_A 1.027 0.94
21_F 46_V 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gllA611000.22Contact Map0.867
1u1zA611000.225Contact Map0.797
4h4gA911000.25Contact Map0.868
4i83A60.98681000.263Contact Map0.84
2cf2C20.96691000.273Contact Map0.141
1z6bA60.98011000.277Contact Map0.849
3d6xA60.95361000.285Contact Map0.821
3q62A20.96691000.288Contact Map0.686
4b0bA20.96031000.299Contact Map0.659
3esiA40.801399.90.508Contact Map0.477

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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