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OPENSEQ.org

EFPL - Elongation factor P-like protein
UniProt: P0A6N8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12035
Length: 190 (186)
Sequences: 1440
Seq/Len: 7.74

EFPL
Paralog alert: 0.27 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: EFP EFPL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
136_E 175_K 4.009 1.00
137_I 176_I 2.785 1.00
18_K 45_D 2.77 1.00
171_S 174_E 2.717 1.00
164_I 176_I 2.591 1.00
70_R 86_D 2.543 1.00
157_T 163_V 2.543 1.00
140_T 156_A 2.52 1.00
138_V 157_T 2.501 1.00
28_Q 38_L 2.44 1.00
75_S 92_P 2.432 1.00
14_N 63_D 2.313 1.00
134_D 175_K 2.164 1.00
106_F 183_R 2.133 1.00
30_P 33_R 2.102 1.00
47_R 123_Q 2.091 1.00
136_E 159_S 2.087 1.00
105_L 162_L 2.058 1.00
7_I 22_V 2.001 1.00
177_R 187_G 1.979 1.00
136_E 172_P 1.965 1.00
108_P 159_S 1.925 1.00
135_L 158_L 1.852 1.00
73_D 87_K 1.833 1.00
4_A 59_D 1.831 1.00
134_D 177_R 1.824 1.00
139_E 172_P 1.756 1.00
137_I 170_L 1.749 1.00
13_L 62_V 1.734 1.00
83_V 94_T 1.723 1.00
139_E 157_T 1.696 1.00
77_V 80_N 1.664 1.00
71_Y 114_D 1.661 1.00
77_V 97_K 1.643 1.00
16_N 54_E 1.617 1.00
71_Y 116_Q 1.612 1.00
136_E 173_G 1.573 1.00
15_Y 54_E 1.568 1.00
156_A 166_V 1.562 1.00
80_N 97_K 1.491 0.99
81_E 94_T 1.482 0.99
140_T 155_P 1.477 0.99
152_R 168_E 1.46 0.99
96_T 99_Q 1.441 0.99
78_D 81_E 1.428 0.99
131_Q 181_E 1.427 0.99
158_L 178_I 1.414 0.99
138_V 158_L 1.406 0.99
143_G 168_E 1.392 0.99
74_F 77_V 1.369 0.99
72_V 93_Y 1.344 0.99
169_Y 185_Y 1.339 0.99
158_L 163_V 1.298 0.98
71_Y 112_M 1.281 0.98
28_Q 33_R 1.28 0.98
145_K 148_S 1.279 0.98
135_L 159_S 1.272 0.98
72_V 117_V 1.272 0.98
119_T 124_L 1.247 0.97
44_S 51_K 1.225 0.97
137_I 172_P 1.213 0.97
73_D 114_D 1.194 0.96
77_V 82_Y 1.182 0.96
117_V 124_L 1.182 0.96
107_M 111_G 1.178 0.96
14_N 121_D 1.173 0.96
13_L 43_F 1.163 0.96
164_I 178_I 1.159 0.96
41_M 56_F 1.149 0.95
138_V 159_S 1.145 0.95
85_M 92_P 1.139 0.95
106_F 162_L 1.138 0.95
134_D 189_A 1.136 0.95
33_R 38_L 1.133 0.95
97_K 104_L 1.127 0.95
19_L 46_V 1.121 0.94
5_N 22_V 1.108 0.94
100_I 127_L 1.102 0.94
81_E 96_T 1.096 0.93
30_P 38_L 1.095 0.93
95_F 99_Q 1.087 0.93
30_P 34_G 1.086 0.93
45_D 48_T 1.072 0.92
84_F 100_I 1.061 0.92
7_I 11_M 1.06 0.92
105_L 183_R 1.058 0.92
24_D 42_R 1.054 0.92
28_Q 40_K 1.047 0.91
158_L 176_I 1.043 0.91
137_I 156_A 1.041 0.91
14_N 120_W 1.041 0.91
132_T 186_M 1.02 0.90
7_I 62_V 1.01 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3treA10.97891000.066Contact Map0.702
3a5zB40.97891000.069Contact Map0.816
1ybyA20.97371000.07Contact Map0.848
1uebA20.96841000.073Contact Map0.8
3oyyA20.97371000.073Contact Map0.738
1bkbA10.67371000.509Contact Map0.644
1iz6A30.68951000.515Contact Map0.791
2eifA10.66841000.519Contact Map0.672
3cpfA20.65791000.527Contact Map0.421
3er0A20.70531000.528Contact Map0.373

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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