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OPENSEQ.org

EFP - Elongation factor P
UniProt: P0A6N4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12099
Length: 188 (185)
Sequences: 1439
Seq/Len: 7.78

EFP
Paralog alert: 0.28 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: EFP EFPL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
134_E 173_V 3.966 1.00
135_I 174_I 2.692 1.00
162_V 174_I 2.688 1.00
20_E 45_R 2.682 1.00
169_Q 172_E 2.638 1.00
71_N 112_E 2.636 1.00
30_V 38_F 2.538 1.00
155_T 161_V 2.536 1.00
70_M 86_N 2.486 1.00
138_T 154_A 2.485 1.00
75_L 92_Q 2.441 1.00
136_V 155_T 2.333 1.00
16_M 63_E 2.33 1.00
106_W 181_G 2.136 1.00
132_E 173_V 2.123 1.00
47_L 121_Q 2.101 1.00
134_E 157_S 2.031 1.00
175_K 185_S 2.019 1.00
108_L 157_S 2.007 1.00
105_K 160_A 1.993 1.00
9_F 24_V 1.972 1.00
134_E 170_I 1.94 1.00
6_S 59_T 1.878 1.00
133_L 156_L 1.85 1.00
15_I 62_A 1.841 1.00
132_E 175_K 1.811 1.00
87_N 112_E 1.78 1.00
73_T 87_N 1.773 1.00
135_I 168_V 1.769 1.00
73_T 112_E 1.766 1.00
137_D 170_I 1.717 1.00
83_H 94_S 1.696 1.00
77_N 80_E 1.679 1.00
71_N 114_I 1.664 1.00
137_D 155_T 1.641 1.00
134_E 171_G 1.581 1.00
18_D 54_K 1.577 1.00
17_L 54_K 1.554 1.00
77_N 97_A 1.553 1.00
154_A 164_V 1.532 1.00
150_G 166_L 1.47 0.99
138_T 153_P 1.463 0.99
81_F 94_S 1.451 0.99
80_E 97_A 1.426 0.99
78_D 81_F 1.42 0.99
136_V 156_L 1.419 0.99
129_N 179_R 1.391 0.99
30_V 34_K 1.377 0.99
72_L 93_L 1.363 0.99
96_D 99_A 1.361 0.99
141_G 166_L 1.359 0.99
74_Y 77_N 1.344 0.99
156_L 176_V 1.31 0.98
72_L 115_V 1.299 0.98
133_L 157_S 1.294 0.98
143_K 146_T 1.285 0.98
156_L 161_V 1.273 0.98
108_L 111_A 1.239 0.97
34_K 38_F 1.221 0.97
115_V 122_P 1.219 0.97
156_L 174_I 1.201 0.97
167_F 183_Y 1.2 0.97
16_M 119_N 1.194 0.96
45_R 48_T 1.172 0.96
77_N 82_W 1.17 0.96
32_P 38_F 1.155 0.95
136_V 157_S 1.134 0.95
26_A 42_K 1.132 0.95
117_L 122_P 1.132 0.95
97_A 104_A 1.127 0.95
100_I 125_V 1.119 0.94
106_W 160_A 1.119 0.94
85_M 92_Q 1.118 0.94
132_E 187_V 1.118 0.94
9_F 62_A 1.113 0.94
41_V 56_F 1.097 0.94
7_N 24_V 1.096 0.93
44_R 51_R 1.09 0.93
95_A 99_A 1.089 0.93
162_V 176_V 1.089 0.93
21_P 46_L 1.088 0.93
9_F 13_L 1.085 0.93
135_I 170_I 1.08 0.93
81_F 96_D 1.067 0.92
15_I 43_L 1.063 0.92
30_V 40_R 1.049 0.91
78_D 94_S 1.049 0.91
17_L 56_F 1.048 0.91
76_Y 83_H 1.045 0.91
84_F 100_I 1.042 0.91
135_I 154_A 1.04 0.91
105_K 181_G 1.026 0.90
32_P 35_G 1.018 0.90
77_N 83_H 1.012 0.89
14_K 21_P 1.003 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3treA111000.037Contact Map0.698
3a5zB411000.04Contact Map0.824
3oyyA20.99471000.043Contact Map0.736
1uebA20.97871000.06Contact Map0.806
1ybyA20.99471000.064Contact Map0.854
1bkbA10.68621000.496Contact Map0.664
1iz6A30.70211000.505Contact Map0.771
2eifA10.68091000.506Contact Map0.714
3er0A20.72341000.517Contact Map0.371
3hksA20.72341000.52Contact Map0.466

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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