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OPENSEQ.org
GLTD - Glutamate synthase [NADPH] small chain
UniProt: P09832 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10404
Length: 472 (466)
Sequences: 2613
Seq/Len: 5.61
GLTD
Paralog alert: 0.56 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: GLTD PRET
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
350_G 363_K 5.281 1.00
145_T 170_V 4.231 1.00
76_R 79_E 4.228 1.00
173_V 214_K 3.818 1.00
254_A 353_V 3.797 1.00
204_E 207_T 3.728 1.00
19_K 27_E 3.445 1.00
175_F 232_Y 3.435 1.00
263_F 306_S 3.265 1.00
174_V 213_F 3.24 1.00
322_E 336_R 3.216 1.00
250_E 350_G 3.18 1.00
291_V 392_A 3.144 1.00
289_R 391_P 3.116 1.00
186_T 200_T 3.075 1.00
417_D 421_R 3.062 1.00
415_E 423_I 2.966 1.00
440_F 469_W 2.964 1.00
236_F 442_G 2.94 1.00
255_D 358_K 2.851 1.00
181_I 215_L 2.783 1.00
227_D 231_D 2.723 1.00
364_M 388_H 2.712 1.00
170_V 467_M 2.681 1.00
361_G 389_I 2.653 1.00
171_K 212_E 2.636 1.00
71_L 83_L 2.622 1.00
354_N 358_K 2.593 1.00
81_A 130_A 2.571 1.00
289_R 393_D 2.528 1.00
289_R 313_H 2.511 1.00
313_H 341_E 2.507 1.00
147_K 233_D 2.477 1.00
161_C 236_F 2.473 1.00
229_L 438_K 2.465 1.00
363_K 389_I 2.457 1.00
204_E 208_G 2.434 1.00
349_L 382_I 2.379 1.00
438_K 469_W 2.368 1.00
236_F 466_I 2.364 1.00
200_T 204_E 2.347 1.00
177_R 218_E 2.334 1.00
152_I 237_L 2.332 1.00
157_A 236_F 2.281 1.00
289_R 312_K 2.245 1.00
467_M 471_E 2.174 1.00
72_A 122_I 2.172 1.00
368_E 381_E 2.103 1.00
218_E 221_R 2.099 1.00
257_V 351_I 2.09 1.00
447_R 458_E 2.062 1.00
291_V 362_V 2.047 1.00
214_K 217_T 2.037 1.00
78_F 82_E 2.016 1.00
154_A 181_I 2.006 1.00
288_K 312_K 1.996 1.00
366_R 388_H 1.967 1.00
166_T 211_I 1.965 1.00
71_L 76_R 1.947 1.00
180_E 200_T 1.941 1.00
129_K 133_M 1.911 1.00
359_V 395_V 1.909 1.00
239_V 445_I 1.908 1.00
224_Q 227_D 1.882 1.00
144_Q 166_T 1.87 1.00
154_A 176_D 1.843 1.00
291_V 390_V 1.818 1.00
97_V 452_V 1.801 1.00
226_D 230_S 1.796 1.00
229_L 436_N 1.783 1.00
433_Q 438_K 1.764 1.00
219_V 223_V 1.759 1.00
352_E 363_K 1.753 1.00
422_I 445_I 1.745 1.00
392_A 395_V 1.707 1.00
181_I 203_R 1.705 1.00
246_R 252_E 1.697 1.00
346_V 388_H 1.685 1.00
351_I 359_V 1.683 1.00
96_R 128_D 1.683 1.00
363_K 387_E 1.653 1.00
315_T 341_E 1.645 1.00
321_D 324_N 1.64 0.99
151_I 172_A 1.639 0.99
144_Q 171_K 1.625 0.99
354_N 360_S 1.62 0.99
181_I 213_F 1.601 0.99
173_V 212_E 1.6 0.99
124_R 128_D 1.6 0.99
217_T 223_V 1.599 0.99
175_F 214_K 1.597 0.99
291_V 317_A 1.58 0.99
168_N 467_M 1.576 0.99
64_Y 67_N 1.576 0.99
352_E 361_G 1.573 0.99
315_T 343_K 1.561 0.99
90_L 174_V 1.559 0.99
147_K 170_V 1.552 0.99
148_K 171_K 1.546 0.99
365_V 382_I 1.54 0.99
81_A 85_H 1.533 0.99
433_Q 440_F 1.524 0.99
251_N 254_A 1.52 0.99
150_A 175_F 1.511 0.99
151_I 158_G 1.496 0.99
173_V 232_Y 1.493 0.99
434_T 441_A 1.493 0.99
364_M 390_V 1.49 0.99
425_P 433_Q 1.484 0.99
150_A 232_Y 1.482 0.99
207_T 213_F 1.469 0.99
236_F 462_A 1.461 0.99
36_S 39_Q 1.46 0.99
217_T 222_D 1.457 0.99
245_M 402_R 1.442 0.98
365_V 386_S 1.431 0.98
383_V 386_S 1.43 0.98
433_Q 437_P 1.415 0.98
111_N 116_A 1.403 0.98
352_E 389_I 1.396 0.98
351_I 395_V 1.392 0.98
77_I 125_Y 1.385 0.98
71_L 79_E 1.377 0.98
360_S 389_I 1.363 0.97
25_K 307_V 1.357 0.97
127_N 136_R 1.356 0.97
72_A 126_I 1.354 0.97
307_V 340_V 1.354 0.97
244_S 259_A 1.343 0.97
70_K 74_E 1.343 0.97
37_E 41_K 1.339 0.97
317_A 390_V 1.328 0.97
176_D 215_L 1.315 0.97
152_I 228_L 1.314 0.97
365_V 387_E 1.307 0.96
85_H 130_A 1.306 0.96
349_L 363_K 1.292 0.96
147_K 470_L 1.28 0.96
384_A 387_E 1.274 0.96
154_A 213_F 1.256 0.95
180_E 187_F 1.252 0.95
465_G 468_N 1.246 0.95
459_G 463_A 1.243 0.95
343_K 346_V 1.24 0.95
457_A 461_K 1.232 0.95
14_V 39_Q 1.23 0.95
343_K 366_R 1.227 0.95
441_A 446_V 1.225 0.94
146_G 171_K 1.225 0.94
238_G 442_G 1.224 0.94
365_V 384_A 1.22 0.94
69_L 122_I 1.215 0.94
148_K 231_D 1.213 0.94
290_V 311_A 1.204 0.94
366_R 386_S 1.204 0.94
161_C 442_G 1.191 0.93
409_L 414_V 1.19 0.93
83_L 86_Q 1.182 0.93
175_F 231_D 1.181 0.93
248_G 252_E 1.178 0.93
89_T 163_D 1.173 0.93
257_V 359_V 1.162 0.92
87_T 460_R 1.157 0.92
186_T 199_M 1.155 0.92
355_G 360_S 1.152 0.92
366_R 383_V 1.145 0.91
352_E 360_S 1.145 0.91
179_P 187_F 1.141 0.91
148_K 232_Y 1.137 0.91
292_V 303_V 1.132 0.91
89_T 164_V 1.129 0.91
129_K 132_E 1.127 0.91
154_A 215_L 1.125 0.90
361_G 391_P 1.123 0.90
373_D 377_R 1.12 0.90
223_V 227_D 1.119 0.90
250_E 363_K 1.117 0.90
300_M 335_A 1.115 0.90
346_V 364_M 1.109 0.90
315_T 392_A 1.106 0.89
63_N 87_T 1.099 0.89
179_P 216_N 1.092 0.89
159_L 174_V 1.077 0.88
249_L 348_P 1.072 0.87
138_D 208_G 1.072 0.87
19_K 31_I 1.069 0.87
226_D 436_N 1.065 0.87
22_K 25_K 1.062 0.87
27_E 31_I 1.061 0.87
303_V 316_C 1.06 0.87
176_D 213_F 1.056 0.86
321_D 345_N 1.054 0.86
241_T 403_P 1.05 0.86
442_G 462_A 1.048 0.86
191_A 268_T 1.044 0.85
88_N 94_C 1.034 0.85
178_H 242_Y 1.027 0.84
68_W 123_E 1.016 0.83
343_K 388_H 1.008 0.83
415_E 435_S 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gteA40.97671000.31Contact Map0.765
2vdcG60.93641000.311Contact Map0.483
1cjcA10.66951000.669Contact Map0.698
1lqtA20.65891000.683Contact Map0.729
1mo9A20.69491000.692Contact Map0.715
1o94A20.89411000.694Contact Map0.473
3k30A20.85811000.706Contact Map0.583
1ps9A10.83691000.713Contact Map0.598
1hyuA10.90471000.715Contact Map0.623
2gagA10.86021000.719Contact Map0.585
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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