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OPENSEQ.org
PRET - NAD-dependent dihydropyrimidine dehydrogenase sunbunit PreT
UniProt: P76440 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14074
Length: 412 (403)
Sequences: 2816
Seq/Len: 6.99
PRET
Paralog alert: 0.63 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: GLTD PRET
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
55_N 58_G 4.801 1.00
151_T 192_K 4.323 1.00
123_T 148_Y 4.138 1.00
182_A 185_E 3.762 1.00
152_I 191_I 3.611 1.00
153_Y 210_N 3.499 1.00
288_L 302_R 3.386 1.00
257_L 337_A 3.317 1.00
376_F 405_Y 3.274 1.00
255_S 336_A 3.261 1.00
164_R 178_D 3.242 1.00
239_F 272_L 3.238 1.00
214_L 378_A 3.2 1.00
139_A 214_L 3.01 1.00
255_S 279_A 3.008 1.00
159_P 193_C 2.898 1.00
50_S 62_T 2.877 1.00
149_D 190_T 2.848 1.00
255_S 338_D 2.785 1.00
60_A 109_E 2.743 1.00
148_Y 403_H 2.736 1.00
205_Q 209_E 2.694 1.00
279_A 307_S 2.608 1.00
207_K 374_Q 2.541 1.00
214_L 402_I 2.527 1.00
182_A 186_K 2.524 1.00
228_F 316_A 2.517 1.00
403_H 407_E 2.485 1.00
130_I 215_V 2.461 1.00
125_G 211_R 2.393 1.00
178_D 182_A 2.39 1.00
196_E 199_N 2.377 1.00
254_Q 278_Q 2.355 1.00
155_K 196_E 2.355 1.00
255_S 278_Q 2.343 1.00
374_Q 405_Y 2.328 1.00
135_A 214_L 2.273 1.00
383_E 394_T 2.26 1.00
144_T 189_V 2.198 1.00
217_V 381_I 2.167 1.00
51_I 101_L 2.135 1.00
57_K 61_E 2.124 1.00
158_H 178_D 2.123 1.00
132_A 154_E 2.111 1.00
108_F 112_T 2.077 1.00
192_K 195_N 2.012 1.00
132_A 159_P 1.998 1.00
197_V 201_L 1.984 1.00
50_S 55_N 1.978 1.00
233_V 317_V 1.962 1.00
257_L 335_M 1.955 1.00
202_T 205_Q 1.924 1.00
204_E 208_A 1.893 1.00
207_K 372_D 1.805 1.00
126_K 149_D 1.803 1.00
369_Q 374_Q 1.799 1.00
358_P 362_T 1.797 1.00
159_P 191_I 1.782 1.00
281_T 307_S 1.765 1.00
185_E 191_I 1.762 1.00
281_T 309_I 1.75 1.00
151_T 210_N 1.75 1.00
76_V 388_V 1.734 1.00
151_T 190_T 1.731 1.00
214_L 398_A 1.731 1.00
60_A 64_R 1.718 1.00
129_I 150_V 1.702 1.00
159_P 181_I 1.693 1.00
195_N 201_L 1.688 1.00
337_A 340_I 1.685 1.00
43_D 46_K 1.659 1.00
103_R 107_D 1.657 1.00
146_Q 403_H 1.656 1.00
122_K 149_D 1.653 1.00
128_A 153_Y 1.632 1.00
49_R 53_F 1.608 1.00
128_A 210_N 1.603 1.00
312_F 333_L 1.579 1.00
69_L 152_I 1.569 1.00
393_K 397_E 1.565 1.00
122_K 144_T 1.562 1.00
257_L 283_V 1.554 1.00
369_Q 373_P 1.553 1.00
50_S 58_G 1.547 0.99
15_T 18_L 1.545 0.99
283_V 335_M 1.522 0.99
16_S 20_I 1.513 0.99
370_T 377_A 1.51 0.99
369_Q 376_F 1.51 0.99
153_Y 192_K 1.504 0.99
323_T 334_T 1.503 0.99
75_R 107_D 1.498 0.99
130_I 206_L 1.487 0.99
287_E 290_E 1.479 0.99
56_F 104_F 1.474 0.99
129_I 136_G 1.461 0.99
273_K 306_V 1.454 0.99
231_S 321_K 1.435 0.99
106_T 115_E 1.427 0.99
157_A 194_N 1.415 0.99
126_K 209_E 1.407 0.99
195_N 200_T 1.4 0.99
216_T 378_A 1.397 0.99
222_G 235_I 1.366 0.98
377_A 382_V 1.359 0.98
395_G 399_A 1.358 0.98
90_A 95_P 1.33 0.98
158_H 165_N 1.327 0.98
317_V 340_I 1.323 0.98
57_K 112_T 1.318 0.98
125_G 148_Y 1.317 0.98
51_I 105_V 1.304 0.98
137_L 152_I 1.3 0.98
62_T 65_E 1.286 0.97
68_A 141_V 1.286 0.97
124_L 149_D 1.285 0.97
201_L 205_Q 1.279 0.97
281_T 337_A 1.263 0.97
148_Y 407_E 1.262 0.97
256_A 277_C 1.26 0.97
48_I 101_L 1.255 0.97
126_K 210_N 1.252 0.97
157_A 165_N 1.246 0.97
243_A 271_T 1.244 0.97
309_I 312_F 1.238 0.97
154_E 193_C 1.229 0.96
401_A 404_H 1.225 0.96
223_S 347_H 1.22 0.96
132_A 191_I 1.209 0.96
316_A 325_K 1.209 0.96
68_A 142_T 1.209 0.96
226_P 229_E 1.205 0.96
125_G 406_L 1.202 0.96
123_T 406_L 1.197 0.96
158_H 249_D 1.189 0.95
269_A 282_C 1.184 0.95
139_A 378_A 1.184 0.95
164_R 177_L 1.178 0.95
258_I 269_A 1.173 0.95
239_F 341_I 1.164 0.95
362_T 365_T 1.163 0.95
378_A 398_A 1.162 0.95
311_G 314_P 1.158 0.95
64_R 109_E 1.157 0.95
66_N 396_K 1.15 0.94
108_F 111_Q 1.144 0.94
153_Y 209_E 1.143 0.94
259_I 340_I 1.141 0.94
318_E 334_T 1.137 0.94
204_E 372_D 1.119 0.93
254_Q 338_D 1.114 0.93
132_A 193_C 1.106 0.93
67_N 73_C 1.104 0.93
42_T 66_N 1.102 0.92
16_S 54_R 1.098 0.92
135_A 378_A 1.092 0.92
129_I 214_L 1.091 0.92
203_L 207_K 1.089 0.92
46_K 62_T 1.084 0.92
156_E 220_S 1.079 0.91
274_V 304_L 1.075 0.91
156_E 241_Q 1.073 0.91
255_S 281_T 1.072 0.91
309_I 333_L 1.064 0.91
123_T 407_E 1.058 0.90
128_A 213_V 1.057 0.90
163_L 172_L 1.056 0.90
361_N 365_T 1.055 0.90
143_L 402_I 1.053 0.90
369_Q 405_Y 1.051 0.90
204_E 207_K 1.051 0.90
364_K 367_N 1.044 0.89
326_H 329_L 1.038 0.89
326_H 333_L 1.038 0.89
316_A 334_T 1.032 0.89
40_A 393_K 1.03 0.89
198_G 201_L 1.028 0.88
283_V 312_F 1.027 0.88
319_G 323_T 1.025 0.88
252_I 339_K 1.024 0.88
358_P 361_N 1.021 0.88
47_F 102_Q 1.015 0.88
148_Y 211_R 1.007 0.87
97_D 100_R 1.005 0.87
269_A 280_V 1 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1gteA411000.258Contact Map0.777
2vdcG60.99031000.28Contact Map0.573
1o94A20.91021000.623Contact Map0.553
1cjcA10.71121000.627Contact Map0.661
3k30A20.90291000.631Contact Map0.608
1lqtA20.70151000.641Contact Map0.678
1mo9A20.76941000.661Contact Map0.643
1ps9A10.85441000.667Contact Map0.677
3lzwA10.68931000.675Contact Map0.622
1hyuA10.9661000.676Contact Map0.526
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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