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OPENSEQ.org
XDHB - Xanthine dehydrogenase FAD-binding subunit
UniProt: Q46800 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13050
Length: 292 (283)
Sequences: 2661
Seq/Len: 9.40
XDHB
Paralog alert: 0.56 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: XDHB YAGS YGFM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
226_R 231_E 3.74 1.00
134_K 145_F 3.316 1.00
136_E 170_H 3.212 1.00
70_R 168_A 2.984 1.00
144_R 164_E 2.983 1.00
136_E 168_A 2.94 1.00
60_G 75_T 2.832 1.00
137_I 146_V 2.792 1.00
147_P 150_G 2.629 1.00
116_C 166_L 2.616 1.00
75_T 80_L 2.561 1.00
135_L 166_L 2.308 1.00
145_F 170_H 2.249 1.00
212_E 235_Q 2.248 1.00
136_E 143_V 2.15 1.00
123_D 185_K 2.015 1.00
132_D 149_N 2.002 1.00
204_R 211_S 1.897 1.00
9_R 54_N 1.893 1.00
59_R 79_Q 1.87 1.00
18_N 22_D 1.857 1.00
52_I 74_A 1.854 1.00
20_L 28_L 1.83 1.00
137_I 160_L 1.829 1.00
76_T 79_Q 1.824 1.00
118_G 158_V 1.774 1.00
204_R 212_E 1.761 1.00
69_L 86_T 1.752 1.00
7_Y 51_D 1.75 1.00
12_T 15_D 1.724 1.00
71_I 80_L 1.722 1.00
28_L 165_I 1.716 1.00
138_H 167_V 1.71 1.00
249_E 273_Q 1.7 1.00
20_L 50_V 1.699 1.00
146_V 159_S 1.699 1.00
135_L 148_I 1.676 1.00
112_G 166_L 1.655 1.00
210_F 213_L 1.64 1.00
136_E 145_F 1.622 1.00
186_Y 271_L 1.618 1.00
134_K 170_H 1.604 1.00
138_H 143_V 1.601 1.00
184_F 278_K 1.56 1.00
239_L 244_L 1.548 1.00
8_H 19_L 1.53 1.00
143_V 167_V 1.527 1.00
206_D 211_S 1.519 1.00
78_T 107_N 1.507 1.00
17_I 139_S 1.493 1.00
28_L 52_I 1.49 1.00
217_F 227_C 1.484 1.00
201_A 279_V 1.48 1.00
63_L 89_H 1.479 1.00
141_R 163_D 1.478 1.00
228_Q 232_Q 1.45 1.00
63_L 173_P 1.438 1.00
217_F 272_I 1.438 1.00
30_A 74_A 1.437 1.00
77_F 109_A 1.433 1.00
78_T 82_E 1.423 0.99
233_T 250_S 1.406 0.99
198_G 218_G 1.391 0.99
77_F 124_S 1.376 0.99
203_C 213_L 1.373 0.99
234_A 247_I 1.359 0.99
153_T 159_S 1.353 0.99
10_A 15_D 1.352 0.99
11_A 15_D 1.341 0.99
149_N 228_Q 1.331 0.99
26_A 50_V 1.328 0.99
229_H 254_D 1.325 0.99
16_A 165_I 1.324 0.99
8_H 48_H 1.312 0.99
30_A 110_T 1.312 0.99
139_S 142_G 1.311 0.99
32_G 36_L 1.311 0.99
229_H 253_Q 1.311 0.99
134_K 147_P 1.303 0.99
246_A 249_E 1.282 0.99
10_A 52_I 1.282 0.99
70_R 170_H 1.282 0.99
141_R 161_E 1.266 0.98
240_N 243_T 1.266 0.98
229_H 232_Q 1.264 0.98
14_A 138_H 1.26 0.98
122_A 125_A 1.245 0.98
201_A 215_L 1.241 0.98
19_L 50_V 1.225 0.98
227_C 230_A 1.218 0.98
182_A 282_E 1.217 0.98
126_T 218_G 1.215 0.98
233_T 237_A 1.215 0.98
148_I 152_H 1.213 0.98
13_L 17_I 1.21 0.98
73_S 112_G 1.206 0.98
17_I 140_P 1.202 0.98
184_F 282_E 1.196 0.98
13_L 165_I 1.185 0.97
23_N 48_H 1.182 0.97
62_T 70_R 1.18 0.97
279_V 283_A 1.176 0.97
77_F 100_I 1.175 0.97
187_A 193_D 1.168 0.97
115_I 169_F 1.167 0.97
9_R 51_D 1.166 0.97
61_I 83_D 1.149 0.97
16_A 55_L 1.147 0.97
125_A 152_H 1.141 0.97
59_R 74_A 1.137 0.96
186_Y 275_M 1.134 0.96
270_H 274_T 1.128 0.96
202_H 214_R 1.126 0.96
13_L 57_E 1.123 0.96
217_F 220_A 1.123 0.96
245_E 277_K 1.122 0.96
60_G 168_A 1.12 0.96
117_N 258_R 1.111 0.96
53_H 76_T 1.104 0.96
263_A 268_R 1.102 0.96
59_R 76_T 1.09 0.95
28_L 50_V 1.082 0.95
213_L 235_Q 1.082 0.95
244_L 248_S 1.081 0.95
67_G 173_P 1.075 0.95
153_T 157_K 1.074 0.95
237_A 246_A 1.073 0.95
241_L 245_E 1.072 0.95
270_H 273_Q 1.071 0.95
215_L 230_A 1.069 0.95
33_T 114_N 1.067 0.94
93_L 127_P 1.063 0.94
34_D 117_N 1.053 0.94
95_A 282_E 1.051 0.94
62_T 65_E 1.05 0.94
68_S 170_H 1.048 0.94
70_R 136_E 1.044 0.94
233_T 243_T 1.041 0.93
115_I 128_T 1.041 0.93
128_T 135_L 1.04 0.93
96_A 127_P 1.033 0.93
100_I 109_A 1.029 0.93
259_S 266_E 1.027 0.93
129_L 148_I 1.027 0.93
230_A 254_D 1.021 0.93
84_P 88_R 1.019 0.92
29_L 32_G 1.018 0.92
210_F 239_L 1.017 0.92
71_I 171_F 1.015 0.92
6_S 48_H 1.014 0.92
137_I 164_E 1.006 0.92
246_A 250_S 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1rm6B20.96231000.092Contact Map0.723
1n62C20.97951000.1Contact Map0.794
1t3qC20.98291000.108Contact Map0.784
3hrdC20.98971000.126Contact Map0.84
3zyvA40.99321000.129Contact Map0.71
1ffvC20.9761000.139Contact Map0.775
2w3sA40.97951000.14Contact Map0.764
3uncA20.99321000.158Contact Map0.751
3nvzB20.97951000.171Contact Map0.736
3tx1A10.8425970.903Contact Map0.579
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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