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OPENSEQ.org
YAGS - Putative xanthine dehydrogenase YagS FAD-binding subunit
UniProt: P77324 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13558
Length: 318 (311)
Sequences: 2307
Seq/Len: 7.42
YAGS
Paralog alert: 0.61 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: XDHB YAGS YGFM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
267_R 272_D 4.373 1.00
175_V 187_S 3.447 1.00
177_E 217_T 3.446 1.00
68_R 215_A 3.176 1.00
58_K 73_V 3.166 1.00
177_E 215_A 3.061 1.00
186_R 211_E 3.046 1.00
189_T 192_D 2.93 1.00
178_T 188_I 2.887 1.00
73_V 78_L 2.67 1.00
176_V 213_I 2.381 1.00
173_D 191_A 2.286 1.00
187_S 217_T 2.231 1.00
67_L 84_V 2.135 1.00
8_R 53_G 2.133 1.00
164_D 230_K 2.007 1.00
177_E 185_T 1.99 1.00
51_V 72_L 1.985 1.00
57_D 77_D 1.98 1.00
17_L 21_R 1.972 1.00
178_T 207_L 1.953 1.00
231_V 302_L 1.936 1.00
19_A 49_I 1.922 1.00
159_A 205_T 1.886 1.00
179_I 214_V 1.876 1.00
27_F 212_L 1.867 1.00
69_I 78_L 1.866 1.00
6_Y 50_D 1.865 1.00
11_T 14_E 1.848 1.00
74_R 77_D 1.818 1.00
19_A 27_F 1.799 1.00
176_V 190_L 1.795 1.00
175_V 217_T 1.789 1.00
27_F 51_V 1.738 1.00
110_A 213_I 1.7 1.00
188_I 206_A 1.689 1.00
16_A 180_T 1.672 1.00
177_E 187_S 1.638 1.00
258_L 268_I 1.63 1.00
76_T 105_N 1.62 1.00
7_E 18_S 1.596 1.00
185_T 214_V 1.594 1.00
243_S 259_G 1.562 1.00
284_D 304_K 1.557 1.00
75_N 107_A 1.549 1.00
229_R 309_S 1.546 1.00
15_A 212_L 1.544 1.00
66_G 217_T 1.544 1.00
232_R 238_A 1.541 1.00
249_Q 253_S 1.539 1.00
7_E 47_H 1.534 1.00
75_N 165_M 1.529 1.00
175_V 189_T 1.527 1.00
182_E 210_G 1.521 0.99
61_V 87_D 1.512 0.99
274_Q 285_T 1.502 0.99
275_L 282_V 1.495 0.99
10_N 14_E 1.491 0.99
268_I 271_A 1.485 0.99
29_A 72_L 1.451 0.99
269_E 273_A 1.448 0.99
61_V 220_P 1.444 0.99
120_P 147_Q 1.439 0.99
246_A 256_V 1.438 0.99
158_I 293_T 1.428 0.99
248_I 254_G 1.405 0.99
270_A 273_A 1.404 0.99
13_A 179_I 1.383 0.99
29_A 108_T 1.383 0.99
31_G 35_L 1.38 0.99
195_H 206_A 1.378 0.99
180_T 183_G 1.365 0.99
191_A 269_E 1.364 0.99
270_A 289_S 1.362 0.99
9_V 51_V 1.348 0.98
12_P 16_A 1.345 0.98
142_E 145_S 1.343 0.98
258_L 303_A 1.343 0.98
8_R 50_D 1.34 0.98
253_S 276_S 1.339 0.98
75_N 98_G 1.336 0.98
9_V 14_E 1.335 0.98
182_E 208_L 1.332 0.98
65_G 220_P 1.327 0.98
271_A 289_S 1.324 0.98
59_I 81_H 1.319 0.98
16_A 181_P 1.318 0.98
18_S 49_I 1.308 0.98
68_R 217_T 1.294 0.98
71_A 110_A 1.291 0.98
58_K 215_A 1.269 0.98
157_C 213_I 1.254 0.97
258_L 261_V 1.244 0.97
60_E 68_R 1.242 0.97
57_D 74_R 1.236 0.97
57_D 72_L 1.23 0.97
179_I 185_T 1.224 0.97
25_A 49_I 1.216 0.97
167_V 259_G 1.212 0.96
164_D 228_Y 1.208 0.96
16_A 212_L 1.2 0.96
78_L 109_T 1.199 0.96
114_L 213_I 1.198 0.96
270_A 288_A 1.197 0.96
98_G 107_A 1.193 0.96
228_Y 243_S 1.192 0.96
247_I 255_R 1.191 0.96
163_S 166_A 1.181 0.96
15_A 54_L 1.179 0.96
166_A 194_Y 1.178 0.96
27_F 49_I 1.171 0.95
256_V 271_A 1.168 0.95
5_T 47_H 1.164 0.95
94_A 168_A 1.153 0.95
281_A 284_D 1.147 0.95
308_A 312_A 1.139 0.95
178_T 211_E 1.138 0.94
52_N 74_R 1.136 0.94
51_V 56_L 1.135 0.94
12_P 212_L 1.133 0.94
12_P 55_G 1.13 0.94
169_M 176_V 1.126 0.94
294_A 297_T 1.125 0.94
76_T 80_A 1.117 0.94
83_R 86_R 1.116 0.94
128_P 139_A 1.101 0.93
113_L 169_M 1.099 0.93
190_L 194_Y 1.097 0.93
93_R 313_E 1.087 0.93
75_N 99_A 1.085 0.92
250_P 277_Q 1.078 0.92
162_P 260_G 1.074 0.92
170_R 190_L 1.073 0.92
100_S 230_K 1.069 0.92
68_R 177_E 1.064 0.91
240_A 243_S 1.056 0.91
231_V 306_T 1.055 0.91
254_G 276_S 1.055 0.91
73_V 109_T 1.05 0.91
310_V 314_A 1.048 0.91
69_I 218_L 1.043 0.90
62_T 68_R 1.04 0.90
28_I 48_L 1.036 0.90
32_T 112_N 1.036 0.90
233_D 236_S 1.03 0.90
19_A 210_G 1.03 0.90
90_V 226_H 1.025 0.89
271_A 285_T 1.024 0.89
12_P 179_I 1.021 0.89
112_N 165_M 1.02 0.89
274_Q 278_G 1.018 0.89
82_E 86_R 1.018 0.89
66_G 220_P 1.013 0.89
91_L 168_A 1.011 0.88
127_Q 139_A 1.001 0.88
257_A 267_R 1.001 0.88
136_S 139_A 1.001 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1rm6B20.95911000.173Contact Map0.699
1t3qC20.83651000.308Contact Map0.79
1n62C20.83961000.311Contact Map0.8
3hrdC20.84281000.318Contact Map0.85
3zyvA40.84281000.327Contact Map0.692
2w3sA40.83331000.332Contact Map0.744
1ffvC20.83961000.337Contact Map0.783
3uncA20.84281000.357Contact Map0.737
3nvzB20.84281000.36Contact Map0.722
3tx1A10.757997.60.91Contact Map0.574
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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